US2002071827A1PendingUtilityA1

Bone graft substitute composition

52
Priority: Jun 7, 1999Filed: Jul 26, 2001Published: Jun 13, 2002
Est. expiryJun 7, 2019(expired)· nominal 20-yr term from priority
Inventors:Donald W. PetersenKelly C. RichelsophWarren HaggardCary P. HaganDonald A. Randolph
A61K 35/32A61F 2002/2835A61K 33/06A61L 27/025A61L 27/3608A61L 27/365A61L 27/446A61L 2430/02
52
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Claims

Abstract

A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, and a mixing solution.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A bone graft substitute composition, consisting essentially of: 
 calcium sulfate;    a mixing solution; and    a plasticizing substance.    
     
     
         2 . The composition of  claim 1 , wherein the calcium sulfate comprises calcium sulfate hemihydrate.  
     
     
         3 . The composition of  claim 1 , wherein the plasticizing substance comprises a cellulose derivative.  
     
     
         4 . The composition of  claim 1 , wherein the plasticizing substance is selected from a group consisting of sodium carboxymethylcellulose, methylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethylcellulose, hydroxyethylcellulose, and cellulose acetate butyrate.  
     
     
         5 . The composition of  claim 1 , wherein the plasticizing substance comprises hydroxypropyl methyl cellulose.  
     
     
         6 . The composition of  claim 1 , wherein the plasticizing substance comprises hydroxypropyl cellulose.  
     
     
         7 . The composition of  claim 1 , wherein the plasticizing substance comprises hyaluronic acid.  
     
     
         8 . The composition of  claim 1 , wherein the plasticizing substance comprises methylcellulose.  
     
     
         9 . The composition of  claim 1 , wherein the mixing solution is selected from a group consisting of sterile water, inorganic salt, and cationic surface active agent.  
     
     
         10 . The composition of  claim 9 , wherein the cationic surface active agent is selected from a group consisting of sodium chloride, phosphate buffered saline, potassium chloride, sodium sulfate, ammonium sulfate, ammonium acetate, and sodium acetate.  
     
     
         11 . The composition of  claim 1 , wherein the mixing solution comprises sterile water.  
     
     
         12 . The composition of  claim 1 , wherein the composition does not comprise a polymer matrix.  
     
     
         13 . The composition of  claim 1 , wherein the composition does not comprise bone.  
     
     
         14 . The composition of  claim 1 , consisting essentially of: 
 100 parts by weight of the calcium sulfate;    about 1.5 to about 8 parts by weight of the plasticizing substance; and    about 25 to about 65 parts by weight of the mixing solution.    
     
     
         15 . The composition of  claim 1 , consisting essentially of: 
 100 parts of the calcium sulfate;    about 5.25 parts by weight of the plasticizing substance; and    about 33.6 parts by weight of the mixing solution.    
     
     
         16 . A bone graft substitute composition, comprising: 
 calcium sulfate;    demineralized bone matrix;    cancellous bone;    a plasticizing substance; and    a mixing solution.    
     
     
         17 . The composition of  claim 16 , wherein the calcium sulfate comprises calcium sulfate hemihydrate.  
     
     
         18 . The composition of  claim 16 , wherein the plasticizing substance comprises a cellulose derivative.  
     
     
         19 . The composition of  claim 16 , wherein the plasticizing substance is selected from a group consisting of sodium carboxymethylcellulose, methylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethylcellulose, hydroxyethylcellulose, and cellulose acetate butyrate.  
     
     
         20 . The composition of  claim 16 , wherein the mixing solution is selected from a group consisting of sterile water, inorganic salt, and cationic surface active agent.  
     
     
         21 . The composition of  claim 20 , wherein the cationic surface active agent is selected from a group consisting of sodium chloride, phosphate buffered saline, potassium chloride, sodium sulfate, ammonium sulfate, ammonium acetate, and sodium acetate.  
     
     
         22 . The composition of  claim 16 , wherein the mixing solution comprises sterile water.  
     
     
         23 . The composition of  claim 16 , comprising: 
 about 80 to about 120 parts by weight of calcium sulfate;    about 10 to about 100 parts by weight of demineralized bone matrix;    about 10 to about 100 parts by weight of cancellous bone;    about 1 to about 40 parts by weight of a plasticizing substance; and    about 21 to about 250 parts by weight of a mixing solution.    
     
     
         24 . The composition of  claim 16 , comprising: 
 about 90 to about 110 parts by weight of calcium sulfate;    about 10 to about 50 parts by weight of demineralized bone matrix;    about 15 to about 50 parts by weight of cancellous bone;    about 5 to about 20 parts by weight of a plasticizing substance; and    about 80 to about 120 parts by weight of a mixing solution.    
     
     
         25 . The composition of  claim 16 , comprising: 
 about 98 to about 102 parts by weight of calcium sulfate;    about 13 to about 23 parts by weight of demineralized bone matrix;    about 27 to about 33 parts by weight of cancellous bone;    about 15 to about 20 parts by weight of a plasticizing substance; and    about 95 to about 105 parts by weight of a mixing solution.    
     
     
         26 . The composition of  claim 16 , comprising: 
 about 100 parts by weight of calcium sulfate;    about 18 to about 19 parts by weight of demineralized bone matrix;    about 27 to about 28 parts by weight of cancellous bone;    about 17 to about 18 parts by weight of a plasticizing substance; and    about 101 to about 102 parts by weight of a mixing solution.    
     
     
         27 . A bone graft substitute composition, comprising: 
 about 80 to about 120 parts by weight of calcium sulfate hemihydrate;    about 10 to about 100 parts by weight of demineralized bone matrix;    about 10 to about 100 parts by weight of cancellous bone;    about 1 to about 40 parts by weight of a carboxymethylcellulose; and    about 21 to about 250 parts by weight of sterile water.    
     
     
         28 . The composition of  claim 27 , comprising: 
 about 90 to about 110 parts by weight of calcium sulfate hemihydrate;    about 10 to about 50 parts by weight of demineralized bone matrix;    about 15 to about 50 parts by weight of cancellous bone;    about 5 to about 20 parts by weight of carboxymethylcellulose; and    about 80 to about 120 parts by weight of sterile water.    
     
     
         29 . The composition of  claim 27 , comprising: 
 about 98 to about 102 parts by weight of calcium sulfate hydrate;    about 13 to about 23 parts by weight of demineralized bone matrix;    about 27 to about 33 parts by weight of cancellous bone;    about 15 to about 20 parts by weight of carboxymethylcellulose; and    about 95 to about 105 parts by weight of sterile water.    
     
     
         30 . The composition of  claim 27 , comprising: 
 about 100 parts by weight of calcium sulfate hemihydrate;    about 18 to about 19 parts by weight of demineralized bone matrix;    about 27 to about 28 parts by weight of cancellous bone;    about 17 to about 18 parts by weight of carboxymethylcellulose; and    about 101 to about 102 parts by weight of sterile water.

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