US2002077275A1PendingUtilityA1

Pharmaceutical compositions comprising prosaposin and neurotrophic polypeptides derived therefrom

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Assignee: MYELOS CORPPriority: Jul 30, 1993Filed: Jan 22, 2001Published: Jun 20, 2002
Est. expiryJul 30, 2013(expired)· nominal 20-yr term from priority
Inventors:John S. O'BrienYasuo Kishimoto
C07K 14/715C07K 7/08C07K 7/06A61K 9/0048A61K 9/0051A61P 25/28A61P 25/16A61K 38/00C07K 14/52A61K 9/19A61P 25/00A61K 9/127C07K 14/475A61K 9/0085A61K 9/0019C07K 14/47C07K 14/71C07K 14/705E03B 7/074Y02A50/30
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Claims

Abstract

Prosaposin, saposin C and various peptide fragments of saposin C stimulate neurite outgrowth in vitro. In addition, prosaposin and saposin C promote increased myelination exvivo. Prosaposin is present in large neurons of the brain, including both upper and lower motor neurons.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A pharmaceutical comprising a neurotrophic polypeptide which comprises amino acids 8-29 of SEQ ID NO: 3, or that includes the active neurotrophic fragment located within amino acids 8-29 of SEQ ID NO: 3, wherein said pharmaceutical is formulated for containment in a septum sealed vial.  
     
     
         2 . The composition of  claim 1 , wherein said polypeptide is saposin C.  
     
     
         3 . A pharmaceutical comprising a neurotrophic polypeptide which comprises amino acids 8-29 of SEQ ID NO: 3, or that includes the active neurotrophic fragment located within amino acids 8-29 of SEQ ID NO: 3, wherein said pharmaceutical is formulated with a controlled release material.  
     
     
         4 . The composition of  claim 3 , wherein said polypeptide is saposin C.  
     
     
         5 . A pharmaceutical comprising a neurotrophic polypeptide which comprises amino acids 8-29 of SEQ ID NO: 3, or that includes the active neurotrophic fragment located within amino acids 8-29 of SEQ ID NO: 3, wherein said pharmaceutical is formulated in liposomal form.  
     
     
         6 . The composition of  claim 5 , wherein said polypeptide is saposin C.

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