US2002082517A1PendingUtilityA1

Tissue marking using biocompatible microparticles

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Assignee: CARBON MEDICAL TECHNOLOGIES INPriority: Aug 15, 2000Filed: Jan 25, 2002Published: Jun 27, 2002
Est. expiryAug 15, 2020(expired)· nominal 20-yr term from priority
Inventors:Dean A. Klein
A61K 49/0419
55
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Claims

Abstract

Described are methods of tissue marking using microparticles that have carbon surfaces, and that contain a contrast agent. Preferred microparticles include a permanently radiopaque particle substrate and a pyrolytic carbon surface.

Claims

exact text as granted — not AI-modified
What is claimed:  
     
         1 . A method for tissue marking comprising delivering detectable microparticles to a tissue site and detecting the microparticles.  
     
     
         2 . The method of  claim 1  wherein the microparticles comprise a radiopaque material.  
     
     
         3 . The method of  claim 2  wherein the radiopaque material is permanently radiopaque.  
     
     
         4 . The method of  claim 3  wherein the radiopaque material is a metal or a metal oxide.  
     
     
         5 . The method of  claim 4  wherein the radiopaque material is titanium, aluminum oxide, zirconium oxide, or a mixture thereof.  
     
     
         6 . The method of  claim 1  wherein the microparticles consist of one or more radiopaque materials.  
     
     
         7 . The method of  claim 1  wherein the microparticle comprises a detectable coating.  
     
     
         8 . The method of  claim 1  wherein the microparticle comprises a substrate and a coating, and the coating comprises a radiopaque additive.  
     
     
         9 . The method of  claim 1  wherein the microparticles comprise a radiopaque substrate and a carbon coating.  
     
     
         10 . The method of  claim 9  wherein the carbon coating comprises pyrolytic carbon.  
     
     
         11 . The method of  claim 9  wherein the carbon comprises low temperature isotropic pyrolytic carbon.  
     
     
         12 . The method of  claim 9  wherein the carbon comprises ultra low temperature isotropic pyrolytic carbon.  
     
     
         13 . The method of  claim 9  wherein the radiopaque substrate comprises a metal or a metal oxide.  
     
     
         14 . The method of  claim 9  wherein the radiopaque substrate comprises titanium, aluminum oxide, zirconium oxide, or a mixture thereof.  
     
     
         15 . The method of  claim 9  wherein the radiopaque substrate is permanently radiopaque.  
     
     
         16 . The method of  claim 1  wherein the average, transverse cross-sectional dimension of the microparticles is between about 100 and about 1000 micrometers.  
     
     
         17 . The method of  claim 1  wherein the average, transverse cross-sectional dimension of the microparticles is between about 251 and about 300 micrometers.  
     
     
         18 . The method of  claim 1  wherein the microparticles are carried in a biocompatible carrier to carry and deliver the microparticles.  
     
     
         19 . The method of  claim 1  wherein the method comprises tissue marking the site of a breast biopsy.  
     
     
         20 . The method of  claim 1  wherein the method comprises tissue marking the site of a prostate biopsy.  
     
     
         21 . The method of  claim 1  wherein the method comprises tissue marking the site of a tissue removal.  
     
     
         22 . The method of  claim 1  wherein the method comprises tissue marking the site of a polyp removal from a rectum or a colon.  
     
     
         23 . The method of  claim 1  wherein the method comprises injecting the microparticles using a hypodermic needle.  
     
     
         24 . The method of  claim 1  wherein the method comprises inserting a hypodermic needle through the sheath of a mammotone to a tissue site, and injecting the microparticles using the hypodermic needle.  
     
     
         25 . The method of  claim 1  wherein the method comprises detecting the microparticles using radiography or fluoroscopy.  
     
     
         26 . A method of tissue marking comprising injecting detectable microparticles to a tissue site through a hypodermic needle, and detecting the microparticles.  
     
     
         27 . The method of  claim 26  wherein the method comprises detecting the microparticles using radiography or fluoroscopy.  
     
     
         28 . A method for marking a biopsy, the method comprising: 
 performing a biopsy; and    marking the site of the biopsy using detectable microparticles injected through a hypodermic needle.    
     
     
         29 . The method of  claim 28  wherein the microparticles are injected using a hypodermic needle and syringe, wherein the needle is inserted through a sheath of a biopsy probe.  
     
     
         30 . The method of  claim 29  wherein the microparticles are delivered through the biopsy probe before the biopsy sheath is moved away from the site of the biopsy.  
     
     
         31 . A method for marking a site of tissue removal, the method comprising: 
 performing a tissue removal procedure; and    marking the site of the tissue removal using detectable microparticles injected through a hypodermic needle.    
     
     
         32 . The method of claim  31  wherein the microparticles are injected using a hypodermic needle, through a mucosa.

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