US2002082692A1PendingUtilityA1

Artificial skin

38
Assignee: ISOTIS NVPriority: Nov 30, 1998Filed: Dec 13, 2001Published: Jun 27, 2002
Est. expiryNov 30, 2018(expired)· nominal 20-yr term from priority
Inventors:C. A. Van BlitterswijkAnnette G. M. Van DorpM. PonecJ. U. Riesle
A61L 27/56A61L 27/60A61L 27/18A61F 2/105
38
PatentIndex Score
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Claims

Abstract

The invention relates to an artificial skin based on a copolymer of a polyalkylene glycol and an aromatic polyester, which skin has a thickness between 50 and 2000 μm, and which skin has an upper and a lower side, both having a macroporosity between 10% and 95%.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . Artificial skin comprising a copolymer of a polyalkylene glycol and an aromatic polyester, said artificial skin having a thickness between 50 and 2000 μm and having an upper and a lower side comprising pores with the upper and the lower side each having a macroporosity between 10% and 95%.  
     
     
         2 . Artificial skin according to  claim 1  further comprising a single layer.  
     
     
         3 . Artificial skin according to  claim 1  wherein the upper and the lower side each has a macroporosity of at least 15%.  
     
     
         4 . Artificial skin according to  claim 3  wherein the upper and the lower side each has a macroporosity of at least 20%.  
     
     
         5 . Artificial skin according to  claim 1  comprising pores having a diameter between 20 and 500 μm.  
     
     
         6 . Artificial skin according to  claim 5  comprising pores having a diameter between 50 and 250 μm.  
     
     
         7 . Artificial skin according to  claim 1  wherein the pores at the upper side have a diameter smaller than the diameter of the pores at the lower side.  
     
     
         8 . Artificial skin according to  claim 8  wherein the pores at the upper side have a diameter of between 0.2 and 5 μm.  
     
     
         9 . Artificial skin according to  claim 7  wherein the pores at the lower side have a diameter of between 20 and 500 μm.  
     
     
         10 . Artificial skin according to  claim 1  wherein the aromatic polyester comprises an alkylene glycol having from 2 to 8 carbon atoms and an aromatic dicarboxylic acid.  
     
     
         11 . Artificial skin according to  claim 1  wherein the polyalkylene glycol comprises one or more of polyethylene glycol, polypropylene glycol, or polybutylene glycol.  
     
     
         12 . Artificial skin according to  claim 10  wherein the aromatic polyester is one or more of poly(ethyleneterephtalate), poly(propyleneterephtalate), and poly(butyleneterephtalate).  
     
     
         13 . Artificial skin according to  claim 1  wherein the copolymer is a polyethylene glycol/poly(butyleneterephtalate) copolymer.  
     
     
         14 . Artificial skin according to  claim 1  wherein the copolymer comprises 40-80 wt. % of the polyalkyleneglycol.  
     
     
         15 . Artificial skin according to  claim 1  wherein the copolymer comprises 50-70 wt. % of the polyalkyleneglycol.  
     
     
         16 . Artificial skin according to  claim 1  comprising autologous cells.  
     
     
         17 . Artificial skin according to  claim 16 , wherein the autologous cells comprise epithelial cells or fibroblasts.  
     
     
         18 . Artificial skin according to  claim 1  comprising a calcium phosphate coating.  
     
     
         19 . Artificial skin according to  claim 1  compatible with skin glands, hair follicles or cells from which skin glands or hair follicles may develop.  
     
     
         20 . Artificial skin according to  claim 1  comprising skin glands, hair follicles or cells which may develop into skin glands or hair follicles.  
     
     
         21 . Artificial skin according to  claim 1  comprising a biologically active agent.  
     
     
         22 . Artificial skin according to  claim 1  comprising keratinocytes.  
     
     
         23 . A method of using an artificial skin according to  claim 1  comprising contacting the artificial skin to a wound of an animal or human.  
     
     
         24 . A method according to  claim 23  wherein the artificial skin comprises one or more of autologous epithelial cells or fibroblasts.

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