Methods for use for integrin b1c cell growth inhibitor

Abstract

The present invention provides a method for inhibiting cell proliferation in a cell comprising contacting the cell with a nucleic acid sequence or a polypeptide having essentially the sequence of the β 1C integrin. Also included in the invention are peptides consisting of amino acid residues which are the size of or fewer than the sequence of the cytoplasmic domain of the β 1C integrin consisting essentially of the amino acid sequence of SEQ ID NO:1 and SEQ ID NO:2, and functional fragments thereof which are useful for inhibiting cellular proliferation. Peptides, polynucleotides, and antibodies immunoreactive with the peptides, and methods of use for inhibiting cell growth are also provided.

What is claimed:  
     
         1 . A method for treating a cellular proliferative disorder in a subject, comprising administering to the subject with the disorder a therapeutically effective amount of β 1C  integrin reagent which inhibits cellular proliferation.  
     
     
         2 . The method of  claim 1 , wherein the β 1C  integrin reagent comprises a nucleic acid sequence encoding β 1C  integrin.  
     
     
         3 . The method of  claim 1 , wherein the β 1C  integrin reagent comprises a polypeptide having an amino acid sequence of β 1C  integrin.  
     
     
         4 . The method of  claim 1 , wherein the reagent is an amino acid sequence comprising of SEQ ID NO:1.  
     
     
         5 . The method of  claim 1 , wherein the reagent is a nucleic acid sequence comprising of a nucleic acid encoding SEQ ID NO:1.  
     
     
         6 . The method of  claim 1 , wherein the reagent is an anti-idiotype antibody which binds to a paratope of an antibody which binds to the amino acid sequence of SEQ ID NO:1.  
     
     
         7 . The method of  claim 1 , wherein the reagent is a peptide as set forth in SEQ ID NO:2.  
     
     
         8 . The method of  claim 1 , wherein the reagent is a nucleic acid sequence encoding SEQ ID NO:2.  
     
     
         9 . The method of  claim 1 , wherein the reagent is an anti-idiotype antibody which binds to a paratope of an antibody which binds to the amino acid sequence of SEQ ID NO:2.  
     
     
         10 . The method of  claim 1 , wherein the cell proliferative disorder is a hematopoietic cell disorder.  
     
     
         11 . A method of inhibiting cell proliferation in a cell comprising contacting the cell with a nucleic acid encoding integrin β 1C , SEQ ID NO: 1 or SEQ ID NO:2, or encoding functional fragments thereof.