Compositions useful for regulating hair growth containing metal complexes of oxidized carbohydrates

Abstract

A stable cosmetic, dermatological, or pharmaceutical composition comprising: (a) from about 0.001% to about 99.9%, by weight, of at least one metal complex of an oxidized carbohydrate; wherein the metal complex of an oxidized carbohydrate is neither zinc gluconate nor manganese gluconate nor lithium gluconate; and (b) from about 0.1% to about 99.999%, by weight, of a vehicle, wherein the vehicle comprises at least about 5%, by weight of the composition, of propylene glycol.

What is claimed is:  
     
         1 . A stable cosmetic, dermatological, or pharmaceutical composition comprising: 
 (a) from about 0.001% to about 99.9%, by weight, of at least one metal complex of an oxidized carbohydrate; wherein said metal complex of an oxidized carbohydrate is neither zinc gluconate nor manganese gluconate nor lithium gluconate; and    (b) from about 0.1% to about 99.999%, by weight, of a vehicle, wherein said vehicle comprises at least about 5%, by weight of the composition, of propylene glycol.    
     
     
         2 . The composition of  claim 1 , wherein said composition comprises: 
 (a) from about 0.001% to about 15%, by weight, of said at least one metal complex of an oxidized carbohydrate; and    (b) from about 85% to about 99.999%, by weight, of said vehicle.    
     
     
         3 . The composition of  claim 1 , wherein the metal comprising said at least one metal complex is selected from the group consisting of lithium, sodium, silver, gold, zinc, copper, nickel, iron, chromium, calcium, magnesium, molybdenum, cobalt, palladium, platinum, tin, and mixtures thereof.  
     
     
         4 . The composition of  claim 3 , wherein said metal comprising said at least one metal complex is selected from the group consisting of lithium, sodium, zinc, copper, and mixtures thereof.  
     
     
         5 . The composition of  claim 4 , wherein said metal comprising said at least one metal complex is zinc.  
     
     
         6 . The composition of  claim 1 , wherein said oxidized carbohydrate is selected from the group consisting of oxidized aldoses, oxidized ketoses, oxidized trioses, oxidized tetroses, oxidized pentoses, oxidized hexoses, and mixtures thereof.  
     
     
         7 . The composition of  claim 1 , wherein said oxidized carbohydrate is selected from the group consisting of ribonic acid; ribulonic acid; arabinonic acid; xylonic acid; xylulonic acid; lyxonic acid; allonic acid; altronic acid; gluconic acid; mannonic acid; gulonic acid; idonic acid; galactonic acid; talonic acid; glucoheptonic acid; psiconic acid; fructonic acid; sorbonic acid; tagatonic acid; lactobionic acid; maltobionic acid; isomaltobionic acid; cellobionic acid; oxidized malto-oligosaccharide; oxidized cello-oligosaccharide; oxidized cellulose; chitin; gum arabic; gum karaya; gum xanthan; oxidized gum guar; oxidized locust bean gum; oxidized agars; oxidized algins; oxidized gellan gum; and mixtures thereof.  
     
     
         8 . The composition of  claim 7 , wherein said oxidized carbohydrate is selected from the group consisting of lactobionic acid; maltobionic acid; isomaltobionic acid; cellobionic acid; and mixtures thereof.  
     
     
         9 . The composition of  claim 8 , wherein said oxidized carbohydrate is lactobionic acid.  
     
     
         10 . The composition of  claim 1 , wherein said oxidized carbohydrate is not gluconate.  
     
     
         11 . The composition of  claim 1 , wherein said composition further comprises a metal complex of an oxidized carbohydrate selected from the group consisting of zinc gluconate, manganese gluconate, lithium gluconate, and mixtures thereof.  
     
     
         12 . The composition of  claim 1 , wherein the carbohydrate comprising said oxidized carbohydrate is selected from the group consisting of monosaccharides, disaccharides, polysaccharides, and mixtures thereof.  
     
     
         13 . The composition of  claim 1 , wherein said vehicle comprises at least one ingredient selected from the group consisting of solvents; thickeners; propellants; powders; fillers; plasticizers; lubricants; and emollients and humectants; and mixtures thereof.  
     
     
         14 . The composition of  claim 13 , wherein said vehicle comprises a solvent selected from the group consisting of water, C 2  to C 3  monohydric alcohols, propylene glycol, and mixtures thereof.  
     
     
         15 . The composition of  claim 14 , wherein said vehicle comprises a solvent comprising: 
 (a) from about 50% to about 70%, by weight, of water;    (b) from about 20% to about 40%, by weight, of ethanol; and    (c) from about 5% to about 20%, by weight, of propylene glycol.    
     
     
         16 . The composition of  claim 14 , wherein said solvent comprises from about 10% to about 15%, by weight, of propylene glycol.  
     
     
         17 . The composition of  claim 1 , wherein said composition further comprises at least one ingredient selected from the group consisting of surfactants, conditioning agents, cationic polymers, anti-dandruff actives, activity enhancers, penetration enhancers, dyes, suspending agents, non-steroidal anti-inflammatory drugs, topical anesthetics, sunscreen actives, flavoring agents, preservatives, sweeteners, and mixtures thereof.  
     
     
         18 . The composition of  claim 17 , wherein: 
 (a) said conditioning agents are selected from the group consisting of polydimethylsiloxane, polydiethylsiloxane, polymethylphenylsiloxane, amodimethicone, trimethylsilylamodimethicone, paraffin oil, mineral oil, polydecene, 1-decene homopolymer, C 8 -C 10  triester of trimethylolpropane, polyethylene glycol, and mixtures thereof; and    (b) said cationic polymers selected from the group consisting of Polyquaternium 10, Polyquaternium 24, guar hydroxypropyltrimethylammonium chloride, Polyquaternium 16, and mixtures thereof; and    (c) said anti-dandruff actives selected from the group consisting of zinc pyrithione, sulfur, ketoconazole, climbazole, and mixtures thereof; and    (d) said activity enhancers selected from the group consisting of minoxidil, finasteride, cyclosporin, ketoconazole, triclocarbon, triclosan, zinc pyrithione, itraconazole, hinokitiol, mipirocin, hydrocortisone, tenidap, triiodothyrionine, latanoprost, isotretinoin, acitretin, tazarotene, nicotinic acid, niacinamide, glycosaminoglycanase inhibitors, ethylenediaminetetraacetic acid, oleanolic acid, ursolic acid, interleukin-1 inhibitors, interleukin-6 inhibitors, interleukin-10 promotors, saponins, triterpenes, betulinic acid, betulonic acid, crataegolic acid, celastrol, asiatic acid, inhibitors of 5-α-reductase, progesterone, 1,4-methyl4-azasteroids, 17-β-N,N-diethylcarbamoyl-4-methyl-4-aza-5-α-androstan-3-one, androgen receptor antagonists, cyproterone acetate, azelaic acid, diazoxide, potassium channel openers, cromakalin, phenytoin, dutasteride, coal tar, zinc gluconate, manganese gluconate, glucocortisoids, macrolides, aminexil, ginkgo biloba, ivy, methyl salicylate, clinacycin hydrochloride, benzoyl peroxide, benzyl peroxide, minocyclin, and mixtures thereof;    (e) said penetration enhancers selected from the group consisting of propan-2-ol; 1-propan-1,2-diol; propan-1-ol; di-isopropyl adipate; dimethylsulfonyl oxide; octonol; niacinamide; and mixtures thereof; and    (f) said suspending agents selected from the group consisting of ethylene glycol monostearate, ethylene glycol distearate, stearyl stearate, cetyl palmitate, xanthan gum, copolymers of acrylic acid crosslinked with polyallylsucrose, methylcellulose, hydroxybutyl methylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose, hydroxyethylcellulose, guar gum, polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl guar gum, starch, trihydroxystearin, and mixtures thereof.    
     
     
         19 . The composition of  claim 18 , wherein said activity enhancers are selected from the group consisting of minoxidil, finasteride, cyclosporin, ketoconazole, triclocarbon, triclosan, zinc pyrithione, itraconazole, tenidap, niacinamide, triterpenes, betulinic acid, betulonic acid, zinc gluconate, manganese gluconate, lithium gluconate, glucocortisoids, and mixtures thereof.  
     
     
         20 . The composition of  claim 1 , wherein said oxidized carbohydrate is amido-, amino-, or phospho-substituted.  
     
     
         21 . A stable cosmetic, dermatological, or pharmaceutical composition comprising: 
 (a) zinc lactobionate;    (b) zinc gluconate, zinc pyrithione, or both; and    (c) a vehicle.    
     
     
         22 . A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to  claim 21 .  
     
     
         23 . A stable cosmetic, dermatological, or pharmaceutical composition comprising: 
 (a) from about 0.001% to about 99.9%, by weight, of at least one metal complex of an oxidized carbohydrate having a solubility in water of at least 10%; and    (b) from about 0.1% to about 99.999%, by weight, of a vehicle, wherein said vehicle comprises at least about 5%, by weight of the composition, of propylene glycol.    
     
     
         24 . A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to  claim 23 .  
     
     
         25 . The composition of  claim 23 , wherein said at least one metal complex of an oxidized carbohydrate has a solubility in water of at least 40%.  
     
     
         26 . The composition of  claim 25 , wherein said at least one metal complex of an oxidized carbohydrate has a solubility in water of at least 50%.  
     
     
         27 . The composition of  claim 26 , wherein said at least one metal complex of an oxidized carbohydrate has a solubility in water of at least 60%.  
     
     
         28 . The composition of  claim 1 , wherein said at least one metal complex of an oxidized carbohydrate is zinc lactobionate.  
     
     
         29 . The composition of  claim 1 , wherein said composition is packaged as a component part of a kit, said kit containing at least one additional component for use in pretreatment or post-treatment steps, said steps being part of a regimen for regulating hair growth performance.  
     
     
         30 . A method for treating hyperandrogenic conditions selected from the group consisting of benign prostatic hyperplasia, androgenetic alopecia, acne vulgaris, female hirsuitism, seborrhea, and prostatic carcinoma, in a human in need of such treatment by disrupting the activity of a hormone selected from the group consisting of testosterone, testosterone derivatives, dihydrotestosterone, dihydrotestosterone derivatives, and combinations thereof, comprising administering to the human an effective amount of a composition according to  claim 1 .  
     
     
         31 . The method of  claim 30 , wherein said composition is administered orally, parenterally, or topically.  
     
     
         32 . The method  claim 31 , wherein said composition is administered in a form selected from the group consisting of tablets, capsules, caplets, creams, gels, hydrogels, lotions, shampoos, rinses, tonics, sprays, ointments, mousses and pomades.  
     
     
         33 . The method of  claim 31 , wherein said composition is administered topically.  
     
     
         34 . A method for treating dandruff comprising administering to a mammal, an effective amount of a composition according to  claim 1 .  
     
     
         35 . A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to  claim 1 .  
     
     
         36 . A method for regulating the growth of finger nails or toe nails comprising administering to a mammal, an effective amount of a composition according to  claim 1 .  
     
     
         37 . A method for styling the hair, comprising administering to the hair of a mammal, an effective amount of a composition according to  claim 1 .  
     
     
         38 . A stable cosmetic, dermatological, or pharmaceutical composition that is the product of a process comprising the steps (a) to (c) in any order: 
 (a) adding from about 1% to about 25%, by weight, of a metal salt, and mixing;    (b) adding from about 1% to about 30%, by weight, of a carboxylic acid of a carbohydrate, and mixing; and    (c) adding from about 0.1% to about 99.999%, by weight, of a vehicle, and mixing;    wherein said product comprises from about 0.001% to about 99.9%, by weight, of at least one metal complex of an oxidized carbohydrate, wherein said metal complex of an oxidized carbohydrate is neither zinc gluconate nor manganese gluconate nor lithium gluconate.    
     
     
         39 . The composition of  claim 38 , wherein the composition is the product of a process comprising the steps (a) to (c) in any order: 
 (a) adding from about 3% to about 10%, by weight, of a metal salt, and mixing;    (b) adding from about 5% to about 25%, by weight, of a carboxylic acid of a carbohydrate, and mixing; and    (c) adding from about 0.1% to about 99.999%, by weight, of a vehicle, and mixing;    wherein said product comprises from about 0.001% to about 15%, by weight, of said metal complex of an oxidized carbohydrate.    
     
     
         40 . The composition of  claim 38 , wherein the metal comprising said metal salt is selected from the group consisting of lithium, sodium, silver, gold, zinc, copper, nickel, iron, chromium, calcium, magnesium, molybdenum, cobalt, palladium, platinum, tin, and mixtures thereof.  
     
     
         41 . The composition of  claim 40 , wherein said metal comprising at least one said metal complex is selected from the group consisting of lithium, sodium, zinc, copper, and mixtures thereof.  
     
     
         42 . The composition of  claim 41 , wherein said metal comprising said at least one metal complex is zinc.  
     
     
         43 . The composition of  claim 38 , wherein said carboxylic acid of a carbohydrate is selected from the group consisting of lactobionic acid; maltobionic acid; isomaltobionic acid; cellobionic acid; and mixtures thereof.  
     
     
         44 . The composition of  claim 43 , wherein said carboxylic acid of a carbohydrate is lactobionic acid.  
     
     
         45 . The composition of  claim 38 , wherein the salt portion of said metal salt is selected from the group consisting of chlorides, sulfates, acetates, oxides, and mixtures thereof.  
     
     
         46 . The composition of  claim 38 , wherein said metal salt is selected from the group consisting of zinc sulfate, zinc acetate, zinc oxide, cupric chloride, cupric sulfate, cupric acetate, and copper oxide.  
     
     
         47 . The composition of  claim 46 , wherein said metal salt is zinc sulfate.  
     
     
         48 . The composition of  claim 43 , wherein said metal salt is zinc sulfate.  
     
     
         49 . A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to  claim 38 .  
     
     
         50 . A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to claim  48 .