Nimesulide gel systems for topical use

Abstract

The present invention relates to nimesulide topical formulations comprising a carboxyvinylpolymer neutralized as a gel-forming agent or a polyacrylamide-isoparaffin and a solvent selected from the group consisting of ethanol, isopropanol and diethylene glycol monoethyl ether, and to the process for the preparation thereof Said formulations have advantages such as higher stability of the system and bioavailability of the active ingredient.

1 . Nimesulide topical formulations in the form of gel systems comprising carboxyvinylpolymer neutralized with aqueous solutions of weak bases or a polyacrylamide-isoparaffin and a solvent selected from the group consisting of ethanol, isopropanol, diethylene glycol monoethyl ether and having a water content ranging from 40 to 95% by weight.  
     
     
         2 . Formulations according to  claim 1 , in which ethanol and isopropanol are used at a concentration ranging from 5% to 20% by weight.  
     
     
         3 . Formulations according to  claim 2 , in which said concentration is 10% by weight.  
     
     
         4 . Formulations according to  claim 1 , in which the diethylene glycol monoethyl ether is used at a concentration ranging from 5% to 40%.  
     
     
         5 . Formulations according to  claim 4 , in which said concentration is 15%.  
     
     
         6 . Formulations according to claims  1 - 5 , in which the weak base used for the neutralization of the carboxyvinylpolymer is triethanolamine or diisopropanolamine.  
     
     
         7 . Formulations according to claims  1 - 6 , in which the active ingredient nimesulide is dispersed in a concentration range of 0.5-7% by weight.  
     
     
         8 . Formulations according to any of the above claims, further comprising additives selected from emollients, humectants, absorption enhancers, preservatives.  
     
     
         9 . Formulations according to  claim 8 , in which the preservatives are imidazolidinyl urea, parabens and EDTA.  
     
     
         10 . A process for the preparation of the formulations of claims  1 - 3  which comprises: 
 preparation of the dispersed phase containing the carboxyvinylpolymer gel-forming agent;  
 addition of the alcoholic solvent, dispersion of the active ingredient nimesulide, addition of preservatives and stabilizing agents;  
 neutralization of the resin with the selected base.  
 
     
     
         11 . A process for the preparation of the formulations of claims  4 - 5  which comprises: 
 preparation of the aqueous phase containing the water-soluble preservatives and the carboxyvinylpolymer homogeneously dispersed;  
 preparation of the phase containing the preservatives (parabens) in diethylene glycol monoethyl ether and dispersion of the active ingredient. Addition of phase consisting of caprylic/capric esters and glyceryl(8)0E;  
 preparation of the dispersion, suspending the phase containing the active ingredient in the aqueous phase containing the carboxyvinylpolymer;  
 preparation of the stabilizers suitably solubilized in the aqueous phase;  
 neutralization of the resin with the selected base.