Implant with bioactive particles stuck and method of manufacturing the same

Abstract

An implant includes a main body member having bio-compatibility, and particles formed of bioactive material and dispersedly provided at the surface of an embedded section of the main body member. Each of the particles has a part embedded in the embedded portion and the other part protruding from the embedded portion. The main body member is formed of titanium or titanium alloy. The particles having osteo-conduction are formed of a material selected from among a group consisting of sintered substances of hydroxylapatite, α-tricalcium phosphate, β-tricalcium phosphate, tetra-calcium phosphate, a single substance of amorphous calcium phosphate, monetite, brushite, 45S4 glass, and a mixture of them. It is desirable that the embedded section surface has a surface roughness in a range of 5 to 50 μm.

What is claimed is:  
     
         1 . An implant comprising: 
 a l main body member having bio-compatibility; and    particles formed of bioactive material and dispersedly provided at a surface of a processed portion of said main body member such that each of said particles has a part embedded in said processed portion surface and a part protruding from said processed portion surface.    
     
     
         2 . An implant according to  claim 1 , wherein said processed portion surface has a surface roughness in a range of 5 to 50 μm.  
     
     
         3 . An implant according to  claim 1 , wherein at least a part of said processed portion surface is formed of one of titanium, titanium alloy and titanium oxide.  
     
     
         4 . An implant according to  claim 1 , wherein said processed portion includes a thread portion provided on an entire of said processed portion.  
     
     
         5 . An implant according to  claim 4 , wherein said thread portion is low in height in a region near an end of said main body member and is high in height in a region apart from the end of said main body member.  
     
     
         6 . An implant according to  claim 1 , wherein said processed portion includes a thread portion provided in a region apart from an end of said main body member.  
     
     
         7 . An implant according to  claim 1 , wherein said particles are formed of a material selected from among a group consisting of sintered substances of hydroxylapatite, α-tricalcium phosphate, β-tricalcium phosphate, tetra-calcium phosphate, a single substance of amorphous calcium phosphate, monetite, brushite, 45S4 glass, and a mixture of them.  
     
     
         8 . An implant according to  claim 1 , wherein each of ones of said particles has a hydroxylapatite layer at said protruding part.  
     
     
         9 . A method of manufacturing an implant, comprising the steps of: 
 providing a main body member having bio-compatibility; and    dispersedly providing particles formed of bioactive material at a surface of a processed portion of said main body member such that each of said particles has a part embedded in said processed surface and a part protruding from said processed surface.    
     
     
         10 . A method according to  claim 9 , wherein at least a part of said processed surface is formed of one of titanium and titanium alloy.  
     
     
         11 . A method according to  claim 9 , wherein said particles have osteo-conduction.  
     
     
         12 . A method according to  claim 9 , wherein said particles are formed of material selected from among a group consisting of sintered substances of hydroxylapatite, α-tricalcium phosphate, β-tricalcium phosphate, tetra-calcium phosphate, a single substance of amorphous calcium phosphate, monetite, brushite, 45S4 glass, and a mixture of them.  
     
     
         13 . A method according to  claim 9 , wherein said step of dispersedly providing particles includes performing a primary sand blasting process to said processed portion surface using said particles.  
     
     
         14 . A method according to  claim 13 , wherein said step of performing a primary sand blasting process includes performing said primary sand blasting process while rotating said main body member.  
     
     
         15 . A method according to  claim 13 , further comprising the step of making said processed portion surface rough through said step of dispersedly providing particles.  
     
     
         16 . A method of manufacturing an implant, comprising the steps of: 
 providing a main body member having bio-compatibility;    making a surface of a processed portion of said main body member rough; and    dispersedly providing particles formed of bioactive material at said processed portion surface such that each of said particles has a part embedded in said processed portion surface and a part protruding from said processed portion surface.    
     
     
         17 . A method according to  claim 16 , wherein said processed portion surface has a surface roughness in a range of 5 to 50 μm.  
     
     
         18 . A method according to  claim 16 , wherein said step of making said processed portion surface rough includes performing a grinding particles blasting process to said processed portion surface using grinding particles.  
     
     
         19 . A method according to  claim 16 , wherein at least a part of said processed portion surface is formed of one of titanium and titanium alloy.  
     
     
         20 . A method according to  claim 16 , wherein said particles are formed of material selected from among a group consisting of sintered substances of hydroxylapatite, α-tricalcium phosphate, β-tricalcium phosphate, tetra-calcium phosphate, a single substance of amorphous calcium phosphate, monetite, brushite, 45S4 glass, and a mixture of them.  
     
     
         21 . A method of manufacturing an implant, comprising the steps of: 
 providing a main body member having bio-compatibility;    dispersedly providing particles formed of material including calcium phosphate at a surface of a proccessed portion of said main body member formed of titanium or titanium alloy such that each of said particles has a part embedded in said processed portion surface and a part protruding from said processed portion surface; and    forming a titanium oxide layer on said processed portion surface and a hydroxylapatite layer on a surface of each of said particles.    
     
     
         22 . A method according to  claim 21 , wherein said step of forming a titanium oxide layer includes performing hydrothermal process to said processed portion surface.  
     
     
         23 . A method according to  claim 22 , wherein a solution used in said hydrothermal process is selected from among a group consisting of pseudo-humor, suspension or saturated solution of calcium phosphate, and mixture solution of them.  
     
     
         24 . A method according to  claim 21 , wherein said particles are formed of material selected from among a group consisting of sintered substances of hydroxylapatite, α-tricalcium phosphate, β-tricalcium phosphate, tetra-calcium phosphate, a single substance of amorphous calcium phosphate, monetite, brushite, 45S4 glass, and a mixture of them.  
     
     
         25 . A method according to claims  21 , further comprising the step of performing a secondary sand blasting process to said processed portion surface using secondary blasting particles formed of bioactive material such that each of said secondary blasting particles has a part embedded in said processed portion surface and a part protruding from said processed portion surface.  
     
     
         26 . A method according to  claim 25 , wherein said secondary blasting particles have osteo-conduction.  
     
     
         27 . A method according to  claim 26 , wherein said secondary blasting particles are formed of material selected from among a group consisting of sintered substances of hydroxylapatite, α-tricalcium phosphate, β-tricalcium phosphate, tetra-calcium phosphate, a single substance of amorphous calcium phosphate, monetite, brushite, 45S4 glass, and a mixture of them.  
     
     
         28 . A method according to  claim 20 , further comprising the step of forming said particles, and 
 wherein said step of forming said particles includes: 
 producing amorphous calcium phosphate by a precipitate method by adding phosphoric acid solution to calcium hydroxide suspension;  
 sintering said amorphous calcium phosphate at a predetermined temperature; and  
 crushing said sintered amorphous calcium phosphate to select said sintered hydroxylapatite particles using a mesh.