Over-coated product including tableted center and medicament

Abstract

Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted center. The tableted center is defined by compressible excipients. By chewing the product, the medicament or agent is released from the product within the buccal cavity.

We claim:  
     
         1 . A method for delivering a medicament to an individual comprising the steps of: 
 providing a product that includes a tableted center and a coating that substantially surrounds the tableted center, the tableted center being defined by at least one compressible excipient, the coating containing a medicament and comprising at least 50% by weight of the product; and    chewing the product to cause the medicament to be released from the product into the buccal cavity of the individual.    
     
     
         2 . The method of  claim 1  wherein the coating includes a high-intensity sweetener.  
     
     
         3 . The method of  claim 1  wherein the high-intensity sweetener is chosen from the group consisting of aspartame, sucralose, saccharin, and acesulfame-k.  
     
     
         4 . The method of  claim 1  wherein the coating is produced by alternating layers of a powder and a syrup onto the tableted center.  
     
     
         5 . The method of  claim 1  wherein the tableted center includes at least one excipient chosen from the group consisting of compressible sacharides and compressible sugar alcohols.  
     
     
         6 . The method of  claim 1  wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; nutraceuticals; nutritional supplements; and cardiovascular agents.  
     
     
         7 . The method of  claim 1  wherein the coating has a polished finish.  
     
     
         8 . A product including a medicament comprising: 
 a tableted center including at least one compressible saccharide or sugar alcohol; and    a coating including a medicament that surrounds the tableted center, the coating comprising at least 50% by weight of the product.    
     
     
         9 . The product of  claim 8  wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; stimulants; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; nutaceuticals; nutritional supplements; and cardiovascular agents.  
     
     
         10 . The product of  claim 8  wherein the coating includes a taste masking agent.  
     
     
         11 . The product of  claim 10  wherein the taste masking agent is chosen from the group consisting of: zinc gluconate, ethyl maltol, glycine, acesulfame-k, aspartame; saccharin; fructose; xylitol; isomalt; maltitol; spray dried licorice root; glycerrhizine; sodium gluconate; glucono delta-lactone; ethyl vanillin; dextrose; sucralose; vanillin; and ethyl maltol.  
     
     
         12 . The product of  claim 10  wherein the taste masking agent comprises approximately 30% to about 99% by weight of the coating.  
     
     
         13 . The product of  claim 8  wherein the coating includes approximately 0.1% to about 5% by weight of a high-intensity sweetener chosen from the group consisting of aspartame, sucralose, saccharine, and acesulfame-k.  
     
     
         14 . The product of  claim 8  wherein the tableted center includes dextrose.  
     
     
         15 . The product of  claim 8  wherein the coating does not have a shellac layer.  
     
     
         16 . A product including a medicament that has acceptable organoleptic properties comprising: 
 a tableted center that is defined by at least one compressible excipient; and    a coating that at least substantially surrounds the tableted center and includes a medicament the coating comprising at least 50% of the product by weight.    
     
     
         17 . The product of  claim 16  wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; stimulants; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; nutraceuticals; nutritional supplements; and cardiovascular agents.  
     
     
         18 . The product of  claim 16  wherein the compressible excipient is chosen from the group consisting of saccharides and sugar alcohols.  
     
     
         19 . The product of  claim 16  wherein a taste masking agent comprises approximately 30% to about 99% by weight of the coating.  
     
     
         20 . The product of  claim 16  wherein the coating includes approximately 0.1% to about 5% by weight of a high-intensity sweetener chosen from the group consisting of aspartame, sucralose, saccharine, and acesulfame-k.  
     
     
         21 . A method of delivering a medicament comprising the steps of: 
 providing a product having a tableted center and a coating that substantially surrounds the center, the center comprising at least one compressible excipient and the coating including a medicament and comprising at least 50% by weight of the product; and    chewing the product to release the medicament into a buccal cavity of an individual chewing the product.    
     
     
         22 . The method of  claim 21  wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; nutriceuticals; nutritional supplements; and cardiovascular agents.  
     
     
         23 . The method of  claim 21  wherein the tableted center includes a saccharide or sugar alcohol.  
     
     
         24 . A method of manufacturing a product containing an agent comprising the steps of: 
 preparing a center by tableting a compressible excipient to produce a tableted center; and    coating the center by placing alternating layers of a powder and a syrup on the center to create a coated product, at least one of the powder or syrup layers including at least one agent.    
     
     
         25 . The method of  claim 24  wherein the coated product comprises at least 50% by weight syrup and powder coating.  
     
     
         26 . The method of  claim 24  wherein the tableted center includes at least one compressible excipient chosen from the group consisting of saccharides and sugar alcohols.  
     
     
         27 . The method of  claim 24  wherein the coating includes a high-intensity sweetener.  
     
     
         28 . The method of  claim 24  wherein the agent is a medicament.  
     
     
         29 . The method of  claim 24  wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; nutraceuticals; nutritional supplements; and cardiovascular agents.  
     
     
         30 . The method of  claim 24  wherein at least two alternating layers are coated on to the center.  
     
     
         31 . The method of  claim 24  wherein the powder comprises at least 70% by weight of the coating.  
     
     
         32 . A method of providing product that includes a medicament comprising the steps of: 
 preparing a center by tableting at least one compressible excipient into a predefined shape; and    coating the predefined shape with at least one layer including a medicament.    
     
     
         33 . The method of  claim 32  wherein the coated product comprises at least 50% by weight syrup and powder coating.  
     
     
         34 . The method of  claim 32  wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; nutraceuticals; nutritional supplements; and cardiovascular agents.  
     
     
         35 . The method of  claim 32  wherein the coating includes a high-intensity sweetener.