Methods and compositions for modulating ubiquitin dependent proteolysis

Abstract

The invention relates to methods and compositions for modulating ubiquitin dependent proteolysis.

We claim:  
     
         1 . A method for modulating ubiquitin dependent proteolysis comprising administering an effective amount of one or more of the following: (a) a complex comprising an E2 ubiquitin conjugating enzyme, a protein of the Cullin family, and a F-box binding protein, and optionally a protein containing an F-box motif; (b) a complex comprising a protein of the Cullin family and a protein containing an F-box motif; (c) a peptide derived from the binding domain of an E2 ubiquitin conjugating enzyme that interacts with a protein of the Cullin family; (d) a peptide derived from the binding domain of a protein of the Cullin family that interacts with an E2 ubiquitin conjugating enzyme; (d) a peptide derived from the binding domain of a protein of the Cullin family that interacts with an F-box binding protein; (e) a peptide derived from the binding domain of an F-box binding protein that interacts with a protein of the Cullin family; (f) enhancers or inhibitors of the interaction of an E2 ubiquitin conjugating enzyme or a F-box binding protein, and a protein of the Cullin family.