Antibodies specific for SSX proteins

Abstract

The invention relates to members of the SSX family of genes, as well as their uses.

What is claimed is:  
     
         1 . Isolated nucleic acid molecule which encodes a protein, the amino acid sequence of which consists of the amino acid sequence encoded by SEQ ID NO: 1, SEQ ID NO: 2, or nucleotides 1-330 concatenated to nucleotides 467-576 of SEQ ID NO: 1.  
     
     
         2 . The isolated nucleic acid molecule of  claim 1 , wherein said isolated nucleic acid molecule encodes the protein encoded by SEQ ID NO: 1.  
     
     
         3 . The isolated nucleic acid molecule of  claim 1 , wherein said isolated nucleic acid molecule encodes the protein encoded by SEQ ID NO: 2.  
     
     
         4 . The isolated nucleic acid molecule of  claim 1 , wherein said isolated nucleic acid molecule encodes the protein encoded by nucleotides 1-330 concatenated to nucleotides 467-576 of SEQ ID NO: 1.  
     
     
         5 . The isolated nucleic acid molecule of  claim 1 , having the nucleotide sequence of SEQ ID NO: 1.  
     
     
         6 . The isolated nucleic acid molecule of  claim 1 , having the nucleotide sequence of SEQ ID NO: 2.  
     
     
         7 . The isolated nucleic acid molecule of  claim 1 , having the nucleotide sequence defined by nucleotides 1-330 concatenated to nucleotides 467-576, as set forth in SEQ ID NO: 1.  
     
     
         8 . Expression vector comprising the isolated nucleic acid molecule of  claim 1 , operably linked to a promoter.  
     
     
         9 . Cell line or cell strain, transformed or transfected with the isolated nucleic acid molecule of  claim 1 .  
     
     
         10 . Cell line or cell strain, transformed or transfected with the expression vector of  claim 8 .  
     
     
         11 . Isolated protein encoded by the isolated nucleic acid molecule of  claim 1   
     
     
         12 . Isolated protein encoded by the isolated nucleic acid molecule of  claim 2   
     
     
         13 . Isolated protein encoded by the isolated nucleic acid molecule of  claim 3   
     
     
         14 . Isolated protein encoded by the isolated nucleic acid molecule of  claim 4   
     
     
         15 . Isolated nucleic acid molecule useful in determining expression of an SSX gene in a sample said isolated nucleic acid molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11 SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14.  
     
     
         16 . Composition useful in determining expression of an SSX gene in a sample, comprising (a) SEQ ID NOS: 3 and SEQ ID NO: 4, (b) SEQ ID NO: 5 and SEQ ID NO: 6, (c) SEQ ID NO: 7 and SEQ ID NO: 8, (d) SEQ ID NO: 9 and SEQ ID NO: 10, (e) SEQ ID NO: 11 and SEQ ID NO: 12, and (f) SEQ ID NO: 13 and SEQ ID NO: 14.  
     
     
         17 . Method for determining expression of an SSX gene in a sample, comprising contacting said sample with at least one isolated nucleic acid molecule of  claim 14  and determining hybridization of said isolated nucleic acid molecule to a target as a determination of expression of an SSX gene in said sample.  
     
     
         18 . Isolated antibody which specifically bonds to the isolated protein of  claim 11 .  
     
     
         19 . Method for determining presence of an expression product of an SSX gene in a sample, comprising contacting saw sample with the isolated antibody of  claim 17  and determining binding of said antibody to a target as a determination of presence of expression product of an SSX gene in said sample.