Method of treatment

Abstract

The invention provides the use of a compound formula (I) wherein R 1 and R 2 independently represent H or C 1 -C 6 alkyl, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of: dermatological disorders; peripheral neuropathies; arthritis; gastrointestinal or urogenital disease; headache associated with substances or their withdrawal; tension headache; pediatric migraine; post-traumatic dysautonomic cephalgia; orofacial pain; allergic or chronic obstructive airways diseases, glaucoma or ocular inflammation; or prophylaxis of migraine

1 . Use of a compound of formula I,  
       
         
           
           
               
               
           
         
       
       wherein R 1  and R 2  independently represent H or C 1 -C 6  alkyl, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of dermatological disorders.  
     
     
         2 . Use of a compound of formula I, as defined in  claim 1 , or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of peripheral neurophathies.  
     
     
         3 . Use of a compound of formula I, as defined in  claim 1 , or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of arthritis.  
     
     
         4 . Use of a compound of formula I, as defined in  claim 1 , or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of gastrointestinal or urogenital diseases.  
     
     
         5 . Use of a compound of formula I, as defined in  claim 1 , or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of headache associated with substances or their withdrawal; tension headache; paediatric migraine; post-traumatic dysautonomic cephalgia; or prophylaxis of migraine.  
     
     
         6 . Use of a compound of formula I, as defined in  claim 1 , or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of orofacial pain.  
     
     
         7 . Use of a compound of formula I, as defined in  claim 1 , or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of allergic or chronic obstructive airways diseases.  
     
     
         8 . Use of a compound of formula I, as defined in  claim 1 , or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of glaucoma or ocular inflammation.  
     
     
         9 . The use as claimed in any one of  claims 1  to  8 , wherein R 1  and R 2  each represent methyl.  
     
     
         10 . The use as claimed in any one of the preceding claims, wherein the compound of formula I is in the form of its fumarate salt.  
     
     
         11 . The use as claimed in  claim 1 , wherein the medicament is for the treatment of pruritis.  
     
     
         12 . The use as claimed in any one of the preceding claims, wherein the compound of formula I has (R)-stereochemistry as shown in formula IA,  
       
         
           
           
               
               
           
         
       
     
     
         13 . A pharmaceutical formulation comprising a compound of formula I, as defined in  claim 1 , or a pharmaceutically acceptable salt thereof, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier, characterized in that the formulation is adapted for administration to the skin.  
     
     
         14 . A method of treatment of: 
 (a) dermatological disorders;    (b) peripheral neurophathies;    (c) arthritis;    (d) gastrointestinal or urogenital diseases;    (e) headache associated with substances or their withdrawal; tension headache; paediatric migraine; post-traumatic dysautonomic cephalgia; or prophylaxis of migraine;    (f) orofacial pain;    (g) allergic or chronic obstructive airways diseases; or    (h) glaucoma or ocular inflammation; which comprises administering a therapeutically effective amount of a compound of formula I, as defined in  claim 1 , or a pharmaceutically acceptable salt thereof, to a patient in need of such treatment or prophylaxis.