Compositions and method for protecting skin from UV induced immunosuppression and skin damage

Abstract

A method for protecting skin from either UV-induced immunosuppression or from UV-induced skin damage comprising the topical administration of a composition containing an extract of soy or clover, and/or the isoflavone compounds genistein, biochanin, dihydro-daidzein, diadzein, formonentin, dihydro-geneistein, 2-dehydro-O-desmethyl-angolensin, tetrahydro-daidzein, equol, dehydro-equol, O-desmethyl-angolensin, or 6-hydroxy-O-desmethyl-angolensin. The invention also comprises compositions containing these compounds.

1 . A composition for application to the skin following UV exposure or for oral administration prior to or following UV exposure, which composition comprises a compound of the general Formula (I)  
       
         
           
           
               
               
           
         
       
       in which 
 Z is H,  
 R 1  is H, or R A CO where R A  is C 1-10  alkyl or an amino acid,  
 R 2  is H, OH, or OR B  where R B  is an amino acid or COR A  where R A  is as previously defined,  
 W is H, A is H or OH, and B is selected from  
                     
 W is H, and A and B taken together form a six membered ring selected from  
                     
 W, A and B taken with the groups with which they are associated comprise  
                     
 W and A taken together with the groups with which they are associated comprise  
                     
 wherein  
 R 3  is H, COR A  where R A  is as previously defined, CO 2 R c  where R c  is C 1-10  alkyl, or  
 COR B  where R B  is as previously defined,  
 R 4  is H, COR D  where R D  is H, OH, C 1-10  alkyl or an amino acid, CO 2 R C  where R C  is as previously defined, COR E  where R E  is H, C 1-10  alkyl or an amino acid, COOH, COR C  where R C  is as previously defined, or CONHR E  where R E  is as previously defined,  
 R 5  is H, CO 2 R C  where R C  is as previously defined, or  
 COR C OR E  where R C  and R are as previously defined, and where the two R 5  groups are attached to the same group they are the same or different,  
 R 6  is H or hydroxy C 1-10  alkyl,  
 X is preferably O, but may be N or S, and  
 Y is  
                     
 where R 7  is H, or C 1-10  alkyl,  
 in association with a dermatologically acceptable or pharmaceutically acceptable carrier.  
 
     
     
         2 . A composition according to  claim 1  wherein compounds of the Formula (I) are selected from:  
       
         
           
           
               
               
           
         
       
       wherein 
 R 7′  is H or CH 3 ,  
 R 8  is COR where R D  is as previously defined, or H,  
 R 9  CO 2 R C  or COR E  where R C  and R E  are as previously defined,  
 R 10  is COR C  or COR C OR E  where R C  and R E  are as previously defined,  
 R 11  is H or OH,  
 R 12  is H, COOH, CO 2 R C  where R C  and is as previously defined, or CONHR E  where R E  is as previously defined,  
 R 13  is OH, OR B  where R B  is as previously defined, or COR A  where R A  is as previously defined,  
 R 14  is H, or COR A  where R A  is as previously defined,  
 R 15  is COR A  where R A  is as previously defined,  
 R 16  is H, COR B  or CO 2 R C  where R B  and R C  are as previously defined,  
 R 17  is H or hydroxy C 1-10  alkyl,  
 R 18  is H or C 1-10  alkyl, and “ --- ” represents either a single bond or a double bond.  
 
     
     
         3 . A method for protecting skin from UV induced immunosuppression and UV induced skin damage which comprises applying to the skin of a subject after UV exposure a composition which comprises a compound of the Formula (I) as defined in  claim 1  or an extract of soy or clover, in association with a dermatologically acceptable carrier.  
     
     
         4 . A method for protecting skin from UV induced immunosuppression and UV induced skin damage which comprises orally administering to a subject either before and/or after UV exposure a composition which comprises a compound of the Formula (I) as defined in  claim 1  or an extract of soy or clover, in association with a pharmaceutically acceptable carrier.  
     
     
         5 . A method according to  claim 3  or 4 wherein the composition includes β-(1,3)(1,6)-glucan.  
     
     
         6 . Use of compounds of the Formula (I) as defined in  claim 1  for the manufacture of a medicament for the treatment, amelioration, prophylaxis and/or prevention of UV induced immunosuppression in the skin, and UV induced skin disorders.  
     
     
         7 . A composition for application to the skin following UV exposure, which composition comprises an extract of soy or clover in association with a dermatologically acceptable carrier.  
     
     
         8 . A composition according to  claim 1 ,  2  or  7  which includes β-(1,3)(1,6)-glucan.  
     
     
         9 . A method for protecting skin from UV induced immunosuppression and UV induced skin damage which comprises applying to the skin of a subject after UV exposure, or orally before or after UV exposure, a composition as defined in any of claims  1 ,  2 ,  7  or  8 .