Pharmaceutical use of N-carbamoylazole derivatives

Abstract

The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl peptidase IV inhibiting agent comprising a compound represented by the general formula (I):

What is claimed is:  
     
         1 . A dipeptidyl peptidase IV inhibiting agent comprising a compound represented by following general formula (I):  
       
         
           
           
               
               
           
         
         wherein R 1a  represents a C 1-6  alkyl group, a C 3-8  cycloalkyl group, a 5- to 10-membered aromatic heterocyclic group, a C 6-10  aromatic hydrocarbon-cyclic group, a 4- to 10-membered heterocyclic group, or a C 4-13  polycycloalkyl group;  
         n means an integer of 0 to 2;  
         W represents a single bond, a C 1-6  alkylene group, or a group represented by following formula W-1:  
         
           
             
             
                 
                 
             
           
         
         wherein W 2  represents a nitrogen atom or methine group, m means an integer of 0 to 3, and R 1b  represents a C 1-6  alkyl group, a C 3-8  cycloalkyl group, a 5- to 10-membered aromatic heterocyclic group, a C 6-10  aromatic hydrocarbon-cyclic group, a 4- to 10-membered heterocyclic group, or a C 4-13  polycycloalkyl group;  
         each of X 1  and X 2  independently represents a nitrogen atom or a methine group;  
         Z represents a group represented by following formula Z-1 or Z-2:  
         
           
             
             
                 
                 
             
           
         
         wherein each of R 2a  and R 2b  independently represents a C 1-6  alkyl group, a C 2-6  alkenyl group, or a phenyl group, and Z 2  represents a sulfur atom or a methylene group; and  
         wherein R 1a  and R 1b  may be substituted with one to three substituents selected from the group consisting of (1) halogen atoms, (2) a hydroxyl group, (3) C 2-6  alkenyl groups, (4) C 2-6  alkynyl groups, (5) a phenyl group, (6) a cyano group, (7) C 1-6  alkoxy groups which may be substituted with one to three halogen atoms or C 1-6  alkoxy groups, and (8) C 1-6  alkyl groups which may be substituted with one to three halogen atoms or C 1-6  alkoxy groups.  
       
     
     
         2 . The dipeptidyl peptidase IV inhibiting agent according to  claim 1 , wherein Z is a group represented by following formula Z-3:  
       
         
           
           
               
               
           
         
         wherein R 2b  represents a C 1-6  alkyl group, a C 2-6  alkenyl group, or a phenyl group.  
       
     
     
         3 . The dipeptidyl peptidase IV inhibiting agent according to  claim 1 , wherein R 1a  is a phenyl group or a 4-pyrazolyl group.  
     
     
         4 . The dipeptidyl peptidase IV inhibiting agent according to  claim 1 , wherein X 1  is a nitrogen atom, and X 2  is a methine group.  
     
     
         5 . The dipeptidyl peptidase IV inhibiting agent according to  claim 1 , wherein X 1  and X 2  are methine group.  
     
     
         6 . The dipeptidyl peptidase IV inhibiting agent according to  claim 1 , wherein n is 1 or 2.  
     
     
         7 . The dipeptidyl peptidase IV inhibiting agent according to  claim 1 , wherein the inhibiting agent is an agent for the treatment and prophylaxis of diabetic diseases.  
     
     
         8 . The dipeptidyl peptidase IV inhibiting agent according to  claim 1 , wherein the inhibiting agent is an agent for the treatment and prophylaxis of obesity.  
     
     
         9 . The dipeptidyl peptidase IV inhibiting agent according to  claim 1 , wherein the inhibiting agent is a hyperlipemia treating agent, an AIDS treating agent, an osteoporosis treating agent, an agent for treating intestinal disorders, a neovascularization treating agent, an infertility treating agent, an anti-inflammatory agent, an anti-allergic agent, an immune-modulating agent, a hormone-modulating agent, an antirheumatic agent, or an agent for treating cancers.