US2003060619A1PendingUtilityA1
Secreted protein HFEAF41
Priority: Mar 21, 1997Filed: Oct 26, 2001Published: Mar 27, 2003
Est. expiryMar 21, 2017(expired)· nominal 20-yr term from priority
Inventors:Paul YoungJohn GreeneAnn FerrieSteven RubenCraig RosenRoxanne DuanJing-Shan HuKimberly FlorenceHenrik OlsenReinhard EbnerLaurie BrewerPaul A. MooreYanggu ShiDavid LafleurJian Ni
A61P 35/00A61P 7/02A61P 37/06A61P 3/10A61P 9/12A61P 9/10A61P 37/08A61P 37/04A61P 7/06A61P 35/02A61P 29/00A61P 25/28A61P 27/02A61P 25/00A61P 25/20A61P 25/30A61P 3/02A61P 3/04A61P 25/18A61P 25/16A61P 21/04C07K 14/47A61P 19/10A61P 17/02A61P 17/06A61P 15/16A61P 11/06A61P 15/08A61P 19/02A61K 38/00C12Q 1/6883G01N 33/6893A61P 17/00A61P 13/12
53
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Claims
Abstract
The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
Claims
exact text as granted — not AI-modified1 . An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of amino acid residues 29 to 99 of SEQ ID NO:142.
2 . The isolated antibody or portion thereof of claim 1 , wherein said protein specifically bound by said antibody or portion thereof is glycosylated.
3 . The isolated antibody or portion thereof of claim 1 which is a monoclonal antibody.
4 . The isolated antibody or portion thereof of claim 1 which is a polyclonal antibody.
5 . The isolated antibody or portion thereof of claim 1 which is a chimeric antibody.
6 . The isolated antibody or portion thereof of claim 1 which is a humanized antibody.
7 . The isolated antibody or portion thereof of claim 1 which is a human antibody.
8 . The isolated antibody or portion thereof of claim 1 which is a Fab fragment.
9 . The isolated antibody or portion thereof of claim 1 which is labeled.
10 . The isolated antibody of claim 9 , wherein the label is selected from the group consisting of:
(a) an enzyme label; (b) a radioisotope; and (c) a fluorescent label.
11 . An isolated cell that produces the isolated antibody of claim 1 .
12 . A hybridoma that produces the isolated antibody of claim 1 .
13 . A hybridoma that produces the isolated antibody of claim 3 .
14 . An isolated antibody produced by immunizing an animal with a protein whose sequence comprises of amino acid residues 29 to 99 of SEQ ID NO:142, wherein said antibody or portion thereof specifically binds to the protein of SEQ ID NO:142.
15 . The isolated antibody of claim 14 , wherein said protein specifically bound by said antibody is glycosylated.
16 . The isolated antibody of claim 14 which is a monoclonal antibody.
17 . The isolated antibody of claim 14 which is a polyclonal antibody.
18 . The isolated antibody of claim 14 which is labeled.
19 . The isolated antibody of claim 18 , wherein the label is selected from the group consisting of:
(d) an enzyme label; (e) a radioisotope; and (f) a fluorescent label.
20 . An isolated cell that produces the isolated antibody of claim 14 .
21 . A hybridoma that produces the isolated antibody of claim 14 .
22 . A hybridoma that produces the isolated antibody of claim 16 .
23 . An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of amino acid residues 1 to 99 of SEQ ID NO:142.
24 . The isolated antibody or portion thereof of claim 23 wherein said protein specifically bound by said antibody or portion thereof is glycosylated.
25 . The isolated antibody or portion thereof of claim 23 which is a monoclonal antibody.
26 . The isolated antibody or portion thereof of claim 23 which is a polyclonal antibody.
27 . The isolated antibody or portion thereof of claim 23 which is a chimeric antibody.
28 . The isolated antibody or portion thereof of claim 23 which is a humanized antibody.
29 . The isolated antibody or portion thereof of claim 23 which is a human antibody.
30 . The isolated antibody or portion thereof of claim 23 which is a Fab fragment.
31 . The isolated antibody or portion thereof of claim 23 which is labeled.
32 . The isolated antibody of claim 31 , wherein the label is selected from the group consisting of:
(a) an enzyme label; (b) a radioisotope; and (c) a fluorescent label.
33 . An isolated cell that produces the isolated antibody of claim 23 .
34 . A hybridoma that produces the isolated antibody of claim 23 .
35 . A hybridoma that produces the isolated antibody of claim 25 .
36 . An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of the amino acid sequence of the secreted polypeptide encoded by the HFEAF41 cDNA contained in ATCC Deposit Number 97923.
37 . The isolated antibody or portion thereof of claim 36 , wherein said protein specifically bound by said antibody or portion thereof is glycosylated.
38 . The isolated antibody or portion thereof of claim 36 which is a monoclonal antibody.
39 . The isolated antibody or portion thereof of claim 36 which is a polyclonal antibody.
40 . The isolated antibody or portion thereof of claim 36 which is a chimeric antibody.
41 . The isolated antibody or portion thereof of claim 36 which is a humanized antibody.
42 . The isolated antibody or portion thereof of claim 36 which is a human antibody.
43 . The isolated antibody or portion thereof of claim 36 which is a Fab fragment.
44 . The isolated antibody or portion thereof of claim 36 which is labeled.
45 . Th e isolated antibody of claim 44 , wherein the label is selected from the group consisting of:
(a) an enzyme label; (b) a radioisotope; and (c) a fluorescent label.
46 . An isolated cell that produces the isolated antibody of claim 36 .
47 . A hybridoma that produces the isolated antibody of claim 36 .
48 . A hybridoma that produces the isolated antibody of claim 38 .
49 . An isolated antibody produced by immunizing an animal with a protein whose sequence comprises the amino acid sequence of the secreted polypeptide encoded by the HFEAF41 cDNA contained in ATCC Deposit Number 97923, wherein said antibody or portion thereof specifically binds to the polypeptide encoded by the HFEAF41 cDNA contained in ATCC Deposit Number 97923.
50 . The isolated antibody of claim 49 , wherein said protein specifically bound by said antibody is glycosylated.
51 . The isolated antibody of claim 49 which is a monoclonal antibody.
52 . The isolated antibody of claim 49 which is a polyclonal antibody.
53 . The isolated antibody of claim 49 which is labeled.
54 . The isolated antibody of claim 53 , wherein the label is selected from the group consisting of:
(g) an enzyme label; (h) a radioisotope; and (i) a fluorescent label.
55 . An isolated cell that produces the isolated antibody of claim 49 .
56 . A hybridoma that produces the isolated antibody of claim 49 .
57 . A hybridoma that produces the isolated antibody of claim 51 .
58 . An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of the amino acid sequence of the full-length polypeptide encoded by the HFEAF41 cDNA contained in ATCC Deposit Number 97923;
59 . The isolated antibody or portion thereof of claim 58 wherein said protein specifically bound by said antibody or portion thereof is glycosylated.
60 . The isolated antibody or portion thereof of claim 58 which is a monoclonal antibody.
61 . The isolated antibody or portion thereof of claim 58 which is a polyclonal antibody.
62 . The isolated antibody or portion thereof of claim 58 which is a chimeric antibody.
63 . The isolated antibody or portion thereof of claim 58 which is a humanized antibody.
64 . The isolated antibody or portion thereof of claim 58 which is a human antibody.
65 . The isolated antibody or portion thereof of claim 58 which is a Fab fragment.
66 . The isolated antibody or portion thereof of claim 58 which is labeled.
67 . The isolated antibody of claim 66 wherein the label is selected from the group consisting of:
(a) an enzyme label;
a radioisotope; and
(c) a fluorescent label.
68 . An isolated cell that produces the isolated antibody of claim 58 .
69 . A hybridoma that produces the isolated antibody of claim 58 .
70 . A hybridoma that produces the isolated antibody of claim 60.Join the waitlist — get patent alerts
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