US2003064412A1PendingUtilityA1

123 human secreted proteins

49
Priority: Jul 8, 1997Filed: Oct 30, 2001Published: Apr 3, 2003
Est. expiryJul 8, 2017(expired)· nominal 20-yr term from priority
Inventors:Carrie FischerCraig RosenDaniel SoppetSteven RubenHla KyawYi LiZhizhen ZengDavid LafleurPaul A. MooreYanggu ShiHenrik OlsenReinhard EbnerLaurie Brewer
A61P 37/00A61P 7/00G01N 33/5058G01N 33/5047A61P 25/00G01N 33/5041G01N 2500/00A61P 29/00G01N 33/68G01N 33/5008C12N 9/00G01N 33/6842G01N 33/505A61K 38/00G01N 33/5011C07K 14/47
49
PatentIndex Score
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Cited by
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References
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Claims

Abstract

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of amino acid residues 21 to 116 of SEQ ID NO:238.  
     
     
         2 . The isolated antibody or portion thereof of  claim 1 , wherein said protein specifically bound by said antibody or portion thereof is glycosylated.  
     
     
         3 . The isolated antibody or portion thereof of  claim 1  which is a monoclonal antibody.  
     
     
         4 . The isolated antibody or portion thereof of  claim 1  which is a polyclonal antibody.  
     
     
         5 . The isolated antibody or portion thereof of  claim 1  which is a chimeric antibody.  
     
     
         6 . The isolated antibody or portion thereof of  claim 1  which is a humanized antibody.  
     
     
         7 . The isolated antibody or portion thereof of  claim 1  which is a human antibody.  
     
     
         8 . The isolated antibody or portion thereof of  claim 1  which is a Fab fragment.  
     
     
         9 . The isolated antibody or portion thereof of  claim 1  which is labeled.  
     
     
         10 . The isolated antibody of  claim 9 , wherein the label is selected from the group consisting of: 
 (a) an enzyme label;    (b) a radioisotope; and    (c) a fluorescent label.    
     
     
         11 . An isolated cell that produces the isolated antibody of  claim 1 .  
     
     
         12 . A hybridoma that produces the isolated antibody of  claim 1 .  
     
     
         13 . A hybridoma that produces the isolated antibody of  claim 3 .  
     
     
         14 . An isolated antibody produced by immunizing an animal with a protein whose sequence comprises of amino acid residues 21 to 116 of SEQ ID NO:238, wherein said antibody or portion thereof specifically binds to the protein of SEQ ID NO:238.  
     
     
         15 . The isolated antibody of  claim 14 , wherein said protein specifically bound by said antibody is glycosylated.  
     
     
         16 . The isolated antibody of  claim 14  which is a monoclonal antibody.  
     
     
         17 . The isolated antibody of  claim 14  which is a polyclonal antibody.  
     
     
         18 . The isolated antibody of  claim 14  which is labeled.  
     
     
         19 . The isolated antibody of  claim 18 , wherein the label is selected from the group consisting of: 
 (a) an enzyme label;    (b) a radioisotope; and    (c) a fluorescent label.    
     
     
         20 . An isolated cell that produces the isolated antibody of  claim 14 .  
     
     
         21 . A hybridoma that produces the isolated antibody of  claim 14 .  
     
     
         22 . A hybridoma that produces the isolated antibody of  claim 16 .  
     
     
         23 . An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of amino acid residues 1 to 116 of SEQ ID NO:238.  
     
     
         24 . The isolated antibody or portion thereof of  claim 23  wherein said protein specifically bound by said antibody or portion thereof is glycosylated.  
     
     
         25 . The isolated antibody or portion thereof of  claim 23  which is a monoclonal antibody.  
     
     
         26 . The isolated antibody or portion thereof of  claim 23  which is a polyclonal antibody.  
     
     
         27 . The isolated antibody or portion thereof of  claim 23  which is a chimeric antibody.  
     
     
         28 . The isolated antibody or portion thereof of  claim 23  which is a humanized antibody.  
     
     
         29 . The isolated antibody or portion thereof of  claim 23  which is a human antibody.  
     
     
         30 . The isolated antibody or portion thereof of  claim 23  which is a Fab fragment.  
     
     
         31 . The isolated antibody or portion thereof of  claim 23  which is labeled.  
     
     
         32 . The isolated antibody of  claim 31 , wherein the label is selected from the group consisting of: 
 (a) an enzyme label;    (b) a radioisotope; and    (c) a fluorescent label.    
     
     
         33 . An isolated cell that produces the isolated antibody of  claim 23 .  
     
     
         34 . A hybridoma that produces the isolated antibody of  claim 23 .  
     
     
         35 . A hybridoma that produces the isolated antibody of  claim 25 .  
     
     
         36 . An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of the amino acid sequence of the secreted polypeptide encoded by the HLHFPO3 cDNA contained in ATCC Deposit No. 209126.  
     
     
         37 . The isolated antibody or portion thereof of  claim 36 , wherein said protein specifically bound by said antibody or portion thereof is glycosylated.  
     
     
         38 . The isolated antibody or portion thereof of  claim 36  which is a monoclonal antibody.  
     
     
         39 . The isolated antibody or portion thereof of  claim 36  which is a polyclonal antibody.  
     
     
         40 . The isolated antibody or portion thereof of  claim 36  which is a chimeric antibody.  
     
     
         41 . The isolated antibody or portion thereof of  claim 36  which is a humanized antibody.  
     
     
         42 . The isolated antibody or portion thereof of  claim 36  which is a human antibody.  
     
     
         43 . The isolated antibody or portion thereof of  claim 36  which is a Fab fragment.  
     
     
         44 . The isolated antibody or portion thereof of  claim 36  which is labeled.  
     
     
         45 . The isolated antibody of  claim 44 , where in the label is selected from the group consisting of: 
 (a) an enzyme label;    (b) a radioisotope; and    (c) a fluorescent label.    
     
     
         46 . An isolated cell that produces the isolated antibody of  claim 36 .  
     
     
         47 . A hybridoma that produces the isolated antibody of  claim 36 .  
     
     
         48 . A hybridoma that produces the isolated antibody of  claim 38 .  
     
     
         49 . An isolated antibody produced by immunizing an animal with a protein whose sequence comprises the amino acid sequence of the secreted polypeptide encoded by the HLIFP03 cDNA contained in ATCC Deposit No. 209126, wherein said antibody or portion thereof specifically binds to the polypeptide encoded by the HLHFP03 cDNA contained in ATCC Deposit No. 209126.  
     
     
         50 . The isolated antibody of  claim 49 , wherein said protein specifically bound by said antibody is glycosylated.  
     
     
         51 . The isolated antibody of  claim 49  which is a monoclonal antibody.  
     
     
         52 . The isolated antibody of  claim 49  which is a polyclonal antibody.  
     
     
         53 . The isolated antibody of  claim 49  which is labeled.  
     
     
         54 . The isolated antibody of  claim 53 , wherein the label is selected from the group consisting of: 
 (a) an enzyme label;    (b) a radioisotope; and    (c) a fluorescent label.    
     
     
         55 . An isolated cell that produces the isolated antibody of  claim 49 .  
     
     
         56 . A hybridoma that produces the isolated antibody of  claim 49 .  
     
     
         57 . A hybridoma that produces the isolated antibody of  claim 51 .  
     
     
         58 . An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of the amino acid sequence of the full-length polypeptide encoded by the HLHFP03 cDNA contained in ATCC Deposit No. 209126;  
     
     
         59 . The isolated antibody or portion thereof of  claim 58  wherein said protein specifically bound by said antibody or portion thereof is glycosylated.  
     
     
         60 . The isolated antibody or portion thereof of  claim 58  which is a monoclonal antibody.  
     
     
         61 . The isolated antibody or portion thereof of  claim 58  which is a polyclonal antibody.  
     
     
         62 . The isolated antibody or portion thereof of  claim 58  which is a chimeric antibody.  
     
     
         63 . The isolated antibody or portion thereof of  claim 58  which is a humanized antibody.  
     
     
         64 . The isolated antibody or portion thereof of  claim 58  which is a human antibody.  
     
     
         65 . The isolated antibody or portion thereof of  claim 58  which is a Fab fragment.  
     
     
         66 . The isolated antibody or portion thereof of  claim 58  which is labeled.  
     
     
         67 . The isolated antibody of  claim 66  wherein the label is selected from the group consisting of: 
 (a) an enzyme label;  
 (b) a radioisotope; and  
 (c) a fluorescent label.  
 
     
     
         68 . An isolated cell that produces the isolated antibody of  claim 58 .  
     
     
         69 . A hybridoma that produces the isolated antibody of  claim 58 .  
     
     
         70 . A hybridoma that produces the isolated antibody of  claim 60.

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