Pharmaceutical compositions and methods of inhibiting angiogenesis using NAALADase inhibitors

Abstract

The present disclosure relates to a method of inhibiting angiogenesis comprising administering a N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) inhibitor to a patient in need thereof, and a pharmaceutical composition comprising an anti-angiogenic effective amount of a NAALADase inhibitor and a pharmaceutically acceptable carrier.

We claim:  
     
         1 . A anti-angiogenic pharmaceutical composition comprising: 
 (i) an effective amount of a NAALADase inhibitor to inhibit angiogenesis; and    (ii) a pharmaceutically acceptable carrier.    
     
     
         2 . The pharmaceutical composition of  claim 1  further comprising at least one additional therapeutic agent.  
     
     
         3 . A method of inhibiting angiogenesis comprising administering an anti-angiogenic amount of a NAALADase inhibitor to a patient.  
     
     
         4 . The method of  claim 3 , wherein the NAALADase inhibitor is administered in combination with at least one additional therapeutic agent.  
     
     
         5 . The method of  claim 3 , wherein the angiogenesis is related to a disease or disorder.  
     
     
         6 . The method of  claim 5 , wherein the disease or disorder is cancer.  
     
     
         7 . The method of  claim 5 , wherein the disease or disorder is a neovascular disease of the eye.  
     
     
         8 . The method of  claim 5 , wherein the disease or disorder is rheumatoid arthritis.  
     
     
         9 . The method of  claim 5 . wherein the disease or disorder is peripheral vascular disorder.  
     
     
         10 . The method of  claim 3 , wherein the angiogenesis is necessary for fertility.  
     
     
         11 . The method of  claim 5 , wherein the disease or disorder is a dermatologic ulcer.  
     
     
         12 . The method of  claim 5 , wherein the disease or disorder is soft tissue wound healing.  
     
     
         13 . The method of  claim 5 , wherein the disease or disorder is cardiovascular disease.  
     
     
         14 . The method of  claim 3 , wherein the angiogenesis is necessary for metastasis of cancer tumors.