Immunotherapy of tumor with monoclonal antibody against the 17-1A antigen

Abstract

Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.

1 . A method of treating gastrointestinal tumor comprising administering to a patient afflicted with a gastrointestinal tumor, a murine monoclonal antibody which specifically binds to an epitope of 17-1A antigen, the antibody being administered parenterally in multiple doses of 100 milligrams or more per dose for a total dose of about 0.1-5 grams of antibody.  
     
     
         2 . A method of  claim 1 , wherein the gastrointestinal tumor is gastrointestinal adenocarcinoma, colorectal or pancreatic carcinoma.  
     
     
         3 . A method of  claim 1 , wherein a mixture of two or more murine monoclonal antibodies which specifically bind an epitope of the 17-1A antigen are administered.  
     
     
         4 . A method of  claim 1 , wherein a dose of antibody is infused intraveneously.  
     
     
         5 . A method of  claim 1 , wherein the total dose is about 1-5 grams.