Use of bradykinin antagonists for stimulating or inducing hair growth and/or arresting hair loss

Abstract

The use of an effective amount of at least one bradykinin antagonist as the active principle in a physiologically acceptable medium in a cosmetic composition or for preparing a drug is disclosed. The antagonist or drug is intended to induce and/or stimulate hair growth, and/or control hair loss.

1 . Use, in a cosmetic composition or for the preparation of a medicinal product, of an effective amount of at least one bradykinin antagonist, this antagonist or the medicinal product being intended to induce and/or stimulate hair growth and/or slow down hair loss.  
     
     
         2 . Use according to the preceding claim, characterized in that the bradykinin antagonist is chosen from compounds which inhibit the synthesis and/or accelerate the catabolism of bradykinin, bradykinin neutralizers, bradykinin receptor blockers such as those which interfere with the effects of bradykinin by binding to its receptor (B1 or B2), compounds which inhibit the synthesis of bradykinin receptors or compounds involved in modulating the signal transduced by bradykinin.  
     
     
         3 . Use according to either of the preceding claims, characterized in that the bradykinin antagonist is chosen from optionally modified, natural or synthetic peptides, natural or synthetic chemical molecules, antisense nucleic acids, ribozymes, anti-bradykinin antibodies, soluble bradykinin receptors, anti-bradykinin-receptor antibodies or bradykinin receptor antagonists.  
     
     
         4 . Use according to any one of the preceding claims, characterized in that the bradykinin antagonist is chosen from compounds which interfere with the effects of bradykinin by binding to its receptor (B1 or B2) and preferably to the B2 receptor.  
     
     
         5 . Use according to any one of the preceding claims, characterized in that the bradykinin antagonist is chosen from 
 D-Arg, [Hyp3, D-Phe7]bradykinin (NPC567),    [Thi5,8, D-Phe7]bradykinin,    D-Arg, [Hyp3, Thi5,8, D-Phe7]bradykinin,    N-α-adamantaneacetyl-D-Arg, [Hyp3, Thi5,8, D-Phe7]-bradykinin,    des-Arg9, [Leu8]bradykinin,    P-guanidobenzoyl, [Hyp3, Thi5, D-Tic7, Oic8]bradykinin (S 16118),    D-Arg, [Hyp3, Thi5, D-Tic7, Oic8]bradykinin (HOE 140),    D-Arg, [Hyp3, D-Hype (transpropyl)7, Oic8]bradykinin (NPC 17731).    
     
     
         6 . Use according to the preceding claim, characterized in that the bradykinin antagonist is D-Arg, [Hyp3, Thi5, D-Tic7, Oic8]bradykinin (HOE 140).  
     
     
         7 . Process for the cosmetic treatment of the hair and/or the scalp, characterized in that it consists in applying a cosmetic composition as defined in any one of  claims 1  to  6  to the hair and/or the scalp, in leaving this composition in contact with the hair and/or the scalp and optionally in carrying out a rinsing operation.