US2003073684A1PendingUtilityA1
Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Priority: Sep 5, 1997Filed: Jun 3, 2002Published: Apr 17, 2003
Est. expirySep 5, 2017(expired)· nominal 20-yr term from priority
Inventors:Amy Bunker Xue-Min Cheng Annette Marian Doherty Jeremy John Edmunds Gerald David Kanter Chitase Lee Joseph Thomas Repine Richard William Skeean
A61P 9/04A61P 9/12A61P 43/00A61P 9/06A61P 3/10A61P 9/10A61P 9/00A61P 35/00C07D 279/02A61P 11/06A61P 1/00C07D 417/04A61P 13/08A61P 13/12C07C 303/40C07D 417/10
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Claims
Abstract

The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
Claims

exact text as granted — not AI-modified
1 . A method of treating subarachnoid hemorrhage comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or 4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         2 . A method of treating essential, renovascular, malignant, or pulmonary hypertension comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5 -Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         3 . A method of treating congestive heart failure comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo [e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         4 . A method of treating cerebral ischemia or cerebral infarction comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo [e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1 -dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1 -dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e]1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1 -dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro- 1λhu 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         5 . A method of treating acute or chronic renal failure comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ6-benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo [e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo [e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e] [1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    b  4 -(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         6 . A method of treating cerebral vasospasm comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         7 . A method of treating cirrhosis comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ6-benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3 -carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         8 . A method of treating septic shock comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         9 . A method of treating endotoxic shock comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ6-benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         10 . A method of treating arrhythmias comprising- administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1 -dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         11 . A method of treating asthma comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)- 1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1 -dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro- 1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         12 . A-method of treating preeclampsia comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;      2 -(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         13 . A method of treating atherosclerotic disorders comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         14 . A method of treating angina comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo [1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         15 . A method of treating cancer comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         16 . A method of treating benign prostatic hyperplasia comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo [e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    
     
     
         17 . A method of treating ischemic disease comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo- 1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         18 . A method of treating gastric mucosal damage comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         19 . A method of treating hemorrhagic shock comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo [e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo [e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)- 1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro- 1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         20 . A method of treating ischemic bowel damage comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1 λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1, 1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         21 . A method of treating diabetes comprising administering to a host suffering therefrom a therapeutically effective amount of 
 4-(3,5-Dimethoxy-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(3,5-dimethoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Chloro-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Benzyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2,6-Dimethyl-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    2-(2-Bromo-phenyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid monosodium salt;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-ethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-propyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-isopropyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-butyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-fluoro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-hydroxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,3-dichloro-phenyl)-1,1-dioxo-1,2-dihydro- 1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,4-dichloro-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-chloro-4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3-chloro-2-methyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2,6-dimethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-1,1-dioxo-2-(2-pyrrol-1-yl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethyl-isoxazol-5-yl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-Benzo[1,3]dioxol-5-yl-2-(2-benzyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid;    4-(6-Methoxy-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid; or    4-(3,5-Dimethyl-phenyl)-2-(2-trifluoromethyl-phenyl)-1,1-dioxo-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid.    
     
     
         22 . A method of inhibiting elevated levels of endothelin, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         23 . A method of treating subarachnoid hemorrhage, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         24 . A method of treating congestive heart failure, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         25 . A method of treating cerebral ischemia or cerebral infarction, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         26 . A method of treating acute or chronic renal failure, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         27 . A method of treating cerebral vasospasm, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         28 . A method of treating cirrhosis, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         29 . A method of treating septic shock comprising, administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         30 . A method of treating endotoxic shock, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         31 . A method of treating arrhythmias, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         32 . A method of treating asthma, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         33 . A method of treating preeclampsia, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         34 . A method of treating atherosclerotic disorders, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         35 . A method of treating angina, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         36 . A method of treating cancer, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         37 . A method of treating benign prostatic hyperplasia, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         38 . A method of treating ischemic disease, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         39 . A method of treating gastric mucosal damage, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         40 . A method of treating hemorrhagic shock, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         41 . A method of treating ischemic bowel damage, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         42 . A method of treating diabetes, comprising administering to a host suffering therefrom a therapeutically effective amount of a compound which is 4-(7-ethyl-benzo[1,3]dioxol-5-yl)-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ 6 -benzo[e][1,2]thiazine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
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