US2003083252A1PendingUtilityA1

Neuronal uses of BMP-11

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Assignee: GENETICS INSTPriority: May 12, 1993Filed: Dec 20, 2001Published: May 1, 2003
Est. expiryMay 12, 2013(expired)· nominal 20-yr term from priority
Inventors:Anthony J. CelesteJohn M. WozneyR. Scott Thies
A61P 43/00A61P 7/00A61P 35/00A61P 25/00A61P 25/28A61P 19/00A61P 15/00C12N 2501/155A61K 38/1875Y10S930/12A61P 13/02C07K 14/575C07K 2319/00C07K 14/51A61P 15/18C12N 5/0619C12N 15/11C12P 21/02
54
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Claims

Abstract

Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A method for modulating neuronal cell development in a mammal comprising the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:11; and (b) administering said composition to said mammal.  
     
     
         2 . A method for inducing neuronal cell formation, growth differentiation, proliferation, and maintenance in a mammal comprising the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:11; and (b) administering said composition to said mammal.  
     
     
         3 . A method of inducing formation of neuronal tissue in a mammal comprising the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:11; and (b) administering said composition to said mammal.  
     
     
         4 . A method of inducing formation of neuronal tissue, wherein said method comprises the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:11; and (b) administering the composition to neuronal cells in vitro and recovering said tissue.  
     
     
         5 . A method for maintaining neuronal tissue comprising the steps of (a) preparing a composition comprising a purified BMP-11 polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:11; and (b) administering said composition to said tissue.  
     
     
         6 . A method for maintaining neuronal tissue comprising the step of administering a composition comprising BMP-11.

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