US2003099719A1PendingUtilityA1

Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol

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Assignee: SLOAN KETTERING INST CANCERPriority: Nov 10, 1997Filed: Sep 30, 2002Published: May 29, 2003
Est. expiryNov 10, 2017(expired)· nominal 20-yr term from priority
Inventors:Raymond P. Warrell, Jr.Pier Paolo PandolfiJanice L. GabriloveRalph EllisonSteven Soignet
A61P 35/00A61K 33/36A61K 41/00A61P 43/00A61P 35/02A61K 31/53A61K 31/555A61K 31/285A61K 33/24
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Claims

Abstract

The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . (New) A method for treating acute myelogenous leukemia in a human comprising administering 0.05 to 5.0 mg/kg arsenic trioxide once per day.  
     
     
         2 . (New) The method of  claim 1 , wherein said arsenic trioxide is administered as 2.5 to 40 mg arsenic trioxide once per day.  
     
     
         3 . (New) The method of  claim 1 , wherein said arsenic trioxide is administered as 0.15 mg/kg arsenic trioxide once per day.  
     
     
         4 . (New) The method of  claim 3 , wherein said acute myelogenous leukemia is acute promyelogenous leukemia.  
     
     
         5 . (New) The method of  claim 4 , wherein said arsenic trioxide is administered until bone marrow remission.  
     
     
         6 . (New) The method of  claim 5 , further comprising a second administration of 0.15 mg/kg arsenic trioxide once per day for 25 doses.  
     
     
         7 . (New) The method of  claim 6 , wherein said second administration is administered 3 to 6 weeks after the first.  
     
     
         8 . (New) The method of  claim 6 , wherein said second administration is administered for up to five weeks.  
     
     
         9 . (New) The method of  claim 8 , wherein said second administration is administered at five doses per week.  
     
     
         10 . (New) The method of  claim 6 , further comprising repeating said second administration.  
     
     
         11 . (New) The method of  claim 10 , wherein said second administration is repeated every 3 to 6 weeks.  
     
     
         12 . (New) The method of  claim 11 , wherein said second administration is repeated until a total of between two and ten cycles of said second administration are completed.  
     
     
         13 . (New) The method of  claim 12 , further comprising repeating said second administration until a total of two cycles of said second administration are completed.  
     
     
         14 . (New) The method of  claim 12 , further comprising repeating said second administration until a total of ten cycles of said second administration are completed.  
     
     
         15 . (New) The method of  claim 4 , wherein said arsenic trioxide is administered for up to sixty days.  
     
     
         16 . (New) The method of  claim 15 , further comprising a second administration of 0.15 mg/kg arsenic trioxide once per day for 25 doses.  
     
     
         17 . (New) The method of  claim 16 , wherein said second administration is administered 3 to 6 weeks after the first.  
     
     
         18 . (New) The method of  claim 16 , wherein said second administration is administered for up to five weeks.  
     
     
         19 . (New) The method of  claim 18 , wherein said second administration is administered at five doses per week.  
     
     
         20 . (New) The method of  claim 16 , further comprising repeating said second administration.  
     
     
         21 . (New) The method of  claim 20 , wherein said second administration is repeated every 3 to 6 weeks.  
     
     
         22 . (New) The method of  claim 21 , wherein said second administration is repeated until a total of between two and ten cycles of said second administration are completed.  
     
     
         23 . (New) The method of  claim 22 , further comprising repeating said second administration until a total of two cycles of said second administration are completed.  
     
     
         24 . (New) The method of  claim 22 , further comprising repeating said second administration until a total of ten cycles of said second administration are completed.

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