US2003108605A1PendingUtilityA1

Mineral supplement

56
Assignee: KV PHARM COPriority: May 31, 2000Filed: Dec 30, 2002Published: Jun 12, 2003
Est. expiryMay 31, 2020(expired)· nominal 20-yr term from priority
Inventors:Marc S. HermelinGeorge ParadissisJames Garegnani
A61K 9/2081
56
PatentIndex Score
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Claims

Abstract

The present invention is directed to a novel flavored extended release composition which forms a non-effervescent suspension when dropped into a liquid, and the methods of using said supplement, thereby minimizing and eliminating gastric discomfort. This flavored extended release composition provides the additional benefits of palatable taste and pleasant appearance.

Claims

exact text as granted — not AI-modified
We claim:  
     
         1 . A solid, dispersible, tableted composition for oral administration to an animal, which comprises: 
 a plurality of extended release particles containing potassium chloride as a therapeutic substance, said particles having a bad taste and being formulated in a solid dispersible tablet, wherein said extended release particles are coated with an extended release agent to provide extended release of the potassium chloride;    a flavoring agent being formulated in the solid dispersible tablet to provide a palatable tasting composition;    wherein the potassium chloride comprises about 20% to about 98% by weight of the solid dispersible tablet;    wherein the solid dispersible tablet forms a non-effervescent flavored suspension when placed in a liquid; and    wherein the non-effervescent flavored suspension after being orally administered to the animal releases the potassium chloride over a period of about 4 hours to about 24 hours.    
     
     
         2 . The composition of  claim 1 , wherein the non-effervescent flavored suspension is formed in less than about 10 minutes after the solid dispersible tablet is placed in the liquid.  
     
     
         3 . The composition of  claim 1 , wherein the non-effervescent flavored suspension is formed in less than about 5 minutes after the solid dispersible tablet is placed in the liquid.  
     
     
         4 . The composition of  claim 1 , wherein the non-effervescent flavored suspension is formed in less than about 1 minute after the solid dispersible tablet is placed in the liquid.  
     
     
         5 . The composition of  claim 1 , wherein the non-effervescent flavored suspension is formed in less than about 30 seconds after the solid dispersible tablet is placed in the liquid.  
     
     
         6 . The composition of  claim 1 , wherein the non-effervescent flavored suspension is formed upon stirring, mixing, or blending the liquid after the solid dispersible tablet is placed in said liquid.  
     
     
         7 . The composition of  claim 1 , wherein the non-effervescent flavored suspension is formed without stirring, mixing or blending the liquid after the solid dispersible tablet is placed in said liquid.  
     
     
         8 . The composition of  claim 1 , wherein the solid dispersible tablet is a self-disbersing tablet.  
     
     
         9 . The composition of  claim 1 , wherein the non-effervescent flavored suspension after being orally administered to the animal releases the potassium chloride over a period from about 12 hours up to about 24 hours.  
     
     
         10 . The composition of  claim 1 , wherein the solid dispersible tablet further contains a coloring agent, and wherein the suspension is a colored suspension.  
     
     
         11 . The composition of  claim 1 , wherein the suspension is a clear suspension.  
     
     
         12 . The composition of  claim 1 , wherein said composition is administered to improve patient compliance with taking the potassium chloride.  
     
     
         13 . The composition of  claim 1 , wherein the composition is administered to improve the swallowing of the potassium chloride.  
     
     
         14 . The composition of  claim 1 , wherein the solid dispersible tablet further contains a natural or artificial sweetening agent.  
     
     
         15 . The composition of  claim 1 , wherein the potassium chloride is present in said solid dispersible tablet in an amount ranging from about 60% to about 85% by weight.  
     
     
         16 . The composition of  claim 1 , wherein the solid dispersible tablet releases an amount of potassium chloride ranging from about 1 mEq to about 40 mEq.  
     
     
         17 . The composition of  claim 1 , wherein the liquid is water.  
     
     
         18 . The composition of  claim 1 , wherein said extended release agent is selected from the group consisting of hydroxypropylmethylcellulose, polyvinylpyrrolidone, and mixtures thereof.  
     
     
         19 . The composition of  claim 1 , wherein the solid dispersible tablet further comprises a disintegrant.  
     
     
         20 . The composition of  claim 1 , wherein the solid dispersible tablet further comprises a lubricant.  
     
     
         21 . The composition of  claim 1 , wherein the composition is administered once a day.  
     
     
         22 . The composition of  claim 1 , wherein the composition is administered at least twice a day.  
     
     
         23 . The composition of  claim 1 , wherein the composition is administered more than twice a day.  
     
     
         24 . The composition of  claim 1 , wherein the animal is a human.  
     
     
         25 . A method of improving patient compliance with a therapeutic or nutritional regimen, which comprises: 
 administering to an animal a non-effervescent flavored suspension formed by placing into a liquid a solid dispersible tablet comprising a flavoring agent and a plurality of particles containing potassium chloride as a therapeutic substance, said particles having a bad taste, said particles being coated with an extended release coating agent;    wherein the non-effervescent flavored suspension after being orally administered to the animal releases the potassium chloride over a period of about 2 hours to about 24 hours.    
     
     
         26 . The method of  claim 25 , wherein the non-effervescent flavored suspension is formed in less than about 10 minutes after the solid dispersible tablet is placed in the liquid.  
     
     
         27 . The method of  claim 25 , wherein the non-effervescent flavored suspension is formed in less than about 5 minutes after the solid dispersible tablet is placed in the liquid.  
     
     
         28 . The method of  claim 25 , wherein the non-effervescent flavored suspension is formed in less than about 1 minute after the solid dispersible tablet is placed in the liquid.  
     
     
         29 . The method of  claim 25 , wherein the non-effervescent flavored suspension is formed in less than about 30 seconds after the solid dispersible tablet is placed in the liquid.  
     
     
         30 . The method of  claim 25 , wherein the non-effervescent flavored suspension is formed upon stirring, mixing or blending the liquid after the solid dispersible tablet is placed in said liquid.  
     
     
         31 . The method of  claim 25 , wherein the non-effervescent flavored suspension is formed without stirring, mixing or blending the liquid after the solid dispersible tablet is placed in said liquid.  
     
     
         32 . The method of  claim 25 , wherein the solid disbersible tablet is a self-disbersing tablet.  
     
     
         33 . The method of  claim 25 , wherein the non-effervescent flavored suspension after being orally administered to the animal releases the potassium chloride over a period of about 12 hours to about 24 hours.  
     
     
         34 . The method of  claim 25 , wherein the solid dispersible tablet further contains a coloring agent, and wherein the suspension is a colored suspension.  
     
     
         35 . The method of  claim 25 , wherein the suspension is a clear suspension.  
     
     
         36 . The method of  claim 25 , wherein the solid dispersible tablet further contains a natural or artificial sweetening agent.  
     
     
         37 . The method of  claim 25 , wherein the potassium chloride is present in said solid dispersible tablet in an amount ranging from about 60% to about 85% by weight.  
     
     
         38 . The method of  claim 25 , wherein the solid dispersible tablet releases an amount of potassium chloride ranging from about 1 mEq to about 40 mEq.  
     
     
         39 . The method of  claim 25 , wherein the liquid is water.  
     
     
         40 . The method of  claim 25 , wherein said extended release agent is selected from the group consisting of hydroxypropylmethylcellulose, polyvinylpyrrolidone, and mixtures thereof.  
     
     
         41 . The method of  claim 25 , wherein the solid dispersible tablet further comprises a disintegrant.  
     
     
         42 . The method of  claim 25 , wherein the solid dispersible tablet further comprises a lubricant.  
     
     
         43 . The method of  claim 25 , wherein the non-effervescent flavored suspension is administered once a day.  
     
     
         44 . The method of  claim 25 , wherein the non-effervescent flavored suspension is administered at least twice a day.  
     
     
         45 . The method of  claim 25 , wherein the animal is a human.

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