Compositions which contain triterpenes for regulating hair growth

Abstract

The present invention relates to compositions containing i) from about 0.0001% to about 99.9% of certain compounds selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, derivatives of ursane triterpenes, and salts and mixtures thereof, and ii) a vehicle.

What is claimed is:  
     
         1 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, α-configuration, and is selected from the group consisting of H and OH;    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 , iii) OH, iv)OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of COCH 3 , CH(OH)CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , C(CH 3 ) 2 R 5 , and CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen,    wherein the compound is not comprised solely of betulinic acid.    
     
     
         2 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, α-configuration, and is selected from the group consisting of H and OH,    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OR 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of C(CH 3 )═CH 2 , CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , and C(CH 3 ) 2 R 5 , CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen,    wherein the compound is not comprised solely of betulinic acid.    
     
     
         3 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, α-configuration, and is selected from the group consisting of: R 4 , OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2  and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ), and    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of C(CH 3 )═CH 2 , CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , and C(CH 3 ) 2 R 5 , CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         4 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and is selected from the group consisting of: R 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , or viii) OCON(R 4 ) 2  and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ),    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , IS OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of C(CH 3 )═CH 2 , CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , and C(CH 3 ) 2 R 5 , CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         5 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R1 is H    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of COCH 3 , CH(OH)CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , C(CH 3 ) 2 R 5 , and CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         6 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R 1  is H;    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OR 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv), OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of C(CH 3 )═CH 2 , CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , and C(CH 3 ) 2 R 5 , CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         7 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R 1  is OH;    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4  where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of COCH 3 , CH(OH)CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , and C(CH 3 ) 2 R 5 , where R 5  is a halogen, wherein the compound is not comprised solely of betulinic acid.    
     
     
         8 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R 1  is OH;    Where R 2  is selected from the group consisting of CH 2 OR 4 , COHNR 4 , and CON(R 4 ) 2 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , or viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is C(CH 3 )═CH 2 .    
     
     
         9 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R1 is OH;    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OR 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4  where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2  and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of CH(CH 3 ) 2  and CH 2 CH 3 .    
     
     
         10 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R 1  is OH;    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , or OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen,    wherein the compound is not comprised solely of betulinic acid.    
     
     
         11 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R 1  is OH,    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4  where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of COCH 3 , CH(OH)CH 3 , and C(R 5 )(CH 3 )CH 2 R 5 , where R 5  is OH,    wherein the compound is not comprised solely of betulinic acid.    
     
     
         12 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R 1  is OH,    Where R 2  is selected from the group consisting of: CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4  where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2  and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is C(CH 3 ) 2 R 5 , where R 5  is OH,    wherein the compound is not comprised solely of betulinic acid.    
     
     
         13 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R 1  is OR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2  and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ),    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4  where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , or viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of C(CH 3 )═CH 2 , CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , C(CH 3 ) 2 R 5 , and CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         14 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpenes having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R 1  is OCOR 4 ;    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , C(CH 3 ) 2 R 5 , and CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         15 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a single bond, β-configuration, and where R 1  is OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2  and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ),    Where R 2  is selected from the group consisting of: CHO, COHNR 4 , CON(R 4 ) 2 , and CH 2 OR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of C(CH 3 )═CH 2 , CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , C(CH 3 ) 2 R 5 , and CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         16 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a double bond and is selected from the group consisting of sulfur and R 4 ,    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl so group, if substituted, is substitured with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of C(CH 3 )═CH 2 , CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , C(CH 3 ) 2 R 5 , and CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         17 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a double bond and is oxygen,    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4  where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of C(CH 3 )═CH 2 , CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , C(CH 3 ) 2 R 5 , and CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         18 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a lupane triterpene having the structure:                          Where R 1  is connected to the ring system via a double bond and is oxygen,    Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4  where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ;    And where R 3  is selected from the group consisting of C(CH 3 )═CH 2 , CH(CH 3 ) 2 , COCH 3 , CH(OH)CH 3 , CH 2 CH 3 , C(R 5 )(CH 3 )CH 2 R 5 , C(CH 3 ) 2 R 5 , and CH(CH 3 )CH 2 R 5 , where R 5  is selected from the group consisting of OH and a halogen.    
     
     
         19 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle; and    b) from about 0.00001% to about 99.9% of a compound selected from the group consisting of: 
 i) compounds having the structure:  
                     where R 1  is selected from the group consisting of CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4 , where R 4  is independently selected from the group consisting of 1) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: a) halogens, b) substituted or unsubstituetd aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  c) OH, d), OR 4 , e) OCOR 4 , f) OCOOR 4 , g) OCONHR 4 , and h) OCON(R 4 ) 2  and 2) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 );    where R 2 =CH 3  or H,    where R 3 =CH 3  or H, and    where R 4 =CH 3  or H; and    
 ii) derivatives of taraxastane triterpenes having the structure:  
                     Where R 1  is either 
 1) connected to the ring system via a single bond, either α- or β-configuration, and is selected from the group consisting of H, OH, OR 4 , R 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 , where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2  and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen and sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2 ), or  
 2) connected to the ring system via a double bond and is selected from the group consisting of a)oxygen, b) sulfur and c) R 4 —, and  
   Where R 2  is selected from the group consisting of: CH 3 , CH 2 OH, CH 2 OR 4 , CHO, CO 2 H, CO 2 R 4 , COHNR 4 , CON(R 4 ) 2 , and CH 2 OCOR 4  where R 4  is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of: i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR 4 , OCOR 4 , OCOOR 4 , OCONHR 4 , and OCON(R 4 ) 2  iii) OH, iv) OR 4 , v) OCOR 4 , vi) OCOOR 4 , vii) OCONHR 4 , and viii) OCON(R 4 ) 2 ; and    
 iii) salts of the acid forms of (i), (ii) or (iii); and  
 iv) mixtures of (i), (ii), or (iii).  
   
     
     
         20 . A composition which comprises a pharmaceutically or cosmetically acceptable vehicle and from 0.00001% to about 99.9% of betulonic acid.  
     
     
         21 . The composition of  claim 20  which additionally comprises minoxidil.  
     
     
         22 . A composition which comprises a pharmaceutically or cosmetically acceptable vehicle and from 0.00001% to about 99.9% of a salt of betulonic acid.  
     
     
         23 . A composition which comprises: 
 a) a pharmaceutically or cosmetically acceptable vehicle;    b) a compound selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, derivatives of ursane triterpenes, and salts and mixtures thereof in a concentration ranging from about 0.0001% to about 99.9%; and    c) a second hair growth agent selected from the group consisting of vasodilators, antiandrogens, immunosuppressants, antiinflammatories, antimicrobials, thyroid hormones, prostoglandins, retinoids, vitamin D analogs, andparathyroid hormone analogs.    
     
     
         24 . The composition of  claim 23  which is a topical composition.  
     
     
         25 . The composition of  claim 24  wherein the pharmaceutically or cosmetically acceptable vehicle is present at a level ranging from about 50% to about 99.99% by weight of the composition.  
     
     
         26 . The composition of  claim 8  wherein the compound is selected from the group consisting of betulinic acid, betulonic acid and mixtures thereof.  
     
     
         27 . The composition of  claim 9  wherein the second hair growth agent is present at a level ranging from about 0.01% to about 10% by weight of the composition.