Separating agent for optical isomer

Abstract

The present invention provides a separating agent for enantiomeric isomers having no large UV absorption as represented by an aromatic group and having high asymmetric recognizability, particularly, high asymmetric recognizability in an aqueous mobile phase, or a separating agent for enantiomeric isomers comprising a polysaccharide alicyclic ester derivative free from aromatic group as an effective component.

1 . A separating agent for enantiomeric isomers comprising a polysaccharide alicyclic ester derivative free from aromatic group as an effective component.  
     
     
         2 . The separating agent for enantiomeric isomers according to  claim 1  wherein the polysaccharide alicyclic ester derivative is a cellulose derivative.  
     
     
         3 . The separating agent for enantiomeric isomers according to one of claims  1  and  2  wherein the alicyclic ester derivative is a cycloalkylcarboxylate derivative.  
     
     
         4 . The separating agent for enantiomeric isomers according to any one of  claims 1  to  3 , which is used as a chiral stationary phase for chromatography.  
     
     
         5 . The separating agent for enantiomeric isomers according to  claim 4  wherein the chiral stationary phase for chromatography is a chiral stationary phase for liquid chromatography used under a reversed phase condition.  
     
     
         6 . The separating agent for enantiomeric isomers according to  claim 5  wherein the reversed phase condition is a condition having a mobile phase consisting of water, alcohol or acetonitrile alone or a mixture containing a plurality of liquids selected therefrom.  
     
     
         7 . The separating agent for enantiomeric isomers according to  claim 4  wherein the chiral stationary phase for chromatography is a stationary phase for thin-layer chromatography.  
     
     
         8 . The separating agent for enantiomeric isomers according to  claim 4  wherein the chiral stationary phase for chromatography is an asymmetry recognition agent added to a migrating liquid of capillary electrophoresis or filled in a capillary.  
     
     
         9 . The separating agent for enantiomeric isomers according to  claim 4  wherein the chiral stationary phase for chromatography is a stationary phase for continuous liquid preparative chromatography.  
     
     
         10 . The separating agent for enantiomeric isomers according to  claim 1  wherein the polysaccharide alicyclic ester derivative is cellulose tris(cyclohexylcarboxylate).  
     
     
         11 . The separating agent for enantiomeric isomers according to  claim 1  wherein the polysaccharide alicyclic ester derivative is cellulose tris(cyclopentylcarboxylate) or cellulose tris(cycloadamantylcarboxylate).  
     
     
         12 . A method for separating enantiomeric isomers by a chromatography having a chiral stationary phase containing a polysaccharide alicyclic ester derivative free from aromatic group as an effective component.  
     
     
         13 . The method according to  claim 12  wherein the polysaccharide alicyclic ester derivative is cellulose tris(cyclopentylcarboxylate) or cellulose tris(cycloadamantylcarboxylate).