US2003143252A1PendingUtilityA1
Inorganic/organic complexes for reducing skin irritation
Priority: Sep 28, 1999Filed: Dec 30, 2002Published: Jul 31, 2003
Est. expirySep 28, 2019(expired)· nominal 20-yr term from priority
A61Q 19/00A61K 8/37A61K 8/35A61K 8/19A61K 2800/58A61Q 17/00A61K 2800/75
55
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Claims
Abstract
β-Diketone/hydroxylated or carbonated activated cation inorganic/organic complexes are well suited for preventing, avoiding or reducing skin irritation, notably that elicited by exposure to irritant active agents/species or to the external environment.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A topically applicable cosmetic/dermatological composition for reducing mammalian skin irritation, comprising an anti-skin-irritant effective amount of at least one compound having the formula (I):
in which the radicals R, which may be identical or different, are each a linear or branched, saturated or unsaturated, optionally hydroxylated alkyl or perfluoroalkyl radical having from 1 to 12 carbon atoms; the radicals R′, which may be identical or different, are each a linear or branched, saturated or unsaturated, optionally hydroxylated alkyl, alkoxy or perfluoroalkyl radical having from 1 to 12 carbon atoms; and X is magnesium, strontium, barium, zinc, manganese or palladium, said compound being in hydrated or nonhydrated form, and a topically applicable, physiologically acceptable medium therefor.
2 . A composition according to claim 1 , wherein, in the compound of formula (I), each radical R is a linear or branched, saturated alkyl or perfluoroalkyl radical having from 1 to 6 carbon atoms.
3 . A composition according to claim 1 , wherein, in the compound of formula (I), each radical R′ is a linear or branched, saturated alkyl, alkoxy or perfluoroalkyl radical having from 1 to 6 carbon atoms.
4 . A composition according to claim 1 , wherein, in the compound of formula (I), R′ is a linear or branched, saturated alkyl, alkoxy or perfluoroalkyl radical having from 1 to 6 carbon atoms.
5 . A composition according to claim 1 , wherein, in the compound of formula (I), the substituents R and R′ are linear.
6 . A composition according to claim 2 , wherein, in the compound of formula (I), the substituents R and R′ are linear.
7 . A composition according to claim 3 , wherein, in the compound of formula (I), the substituents R and R′ are linear.
8 . A composition according to claim 4 , wherein, in the compound of formula (I), the substituents R and R′ are linear.
9 . A composition according to claim 1 , wherein, in the compound of formula (I), the substituents R and R′ are saturated.
10 . A composition according to claim 2 , wherein, in the compound of formula (I), the substituents R and R′ are saturated.
11 . A composition according to claim 1 , wherein, in the compound of formula (I), the substituents R and R′ comprise a difference of at most two carbon atoms with respect to each other.
12 . A composition according to claim 2 , wherein, in the compound of formula (I), the substituents R and R′ comprise a difference of at most two carbon atoms with respect to each other.
13 . A composition according to claim 3 , wherein, in the compound of formula (I), the substituents R and R′ comprise a difference of at most two carbon atoms with respect to each other.
14 . A composition according to claim 4 , wherein, in the compound of formula (I), the substituents R and R′ comprise a difference of at most two carbon atoms with respect to each other.
15 . A composition according to claim 1 , wherein, in the compound of formula (I), X is strontium or zinc.
16 . A composition according to claim 2 , wherein, in the compound of formula (I), X is strontium or zinc.
17 . A composition according to claim 3 , wherein, in the compound of formula (I), X is strontium or zinc.
18 . A composition according to claim 4 , wherein, in the compound of formula (I), X is strontium or zinc.
19 . A composition according to claim 5 , wherein, in the compound of formula (I), X is strontium or zinc.
20 . A composition according to claim 6 , wherein, in the compound of formula (I), X is strontium or zinc.
21 . A composition according to claim 7 , wherein, in the compound of formula (I), X is strontium or zinc.
22 . A composition according to claim 8 , wherein, in the compound of formula (I), X is strontium or zinc.
23 . A composition according to claim 9 , wherein, in the compound of formula (I), X is strontium or zinc.
24 . A composition according to claim 10 , wherein, in the compound of formula (I), X is strontium or zinc.
25 . A composition according to claim 11 , wherein, in the compound of formula (I), X is strontium or zinc.
26 . A composition according to claim 12 , wherein, in the compound of formula (I), X is strontium or zinc.
27 . A composition according to claim 13 , wherein, in the compound of formula (I), X is strontium or zinc.
28 . A composition according to claim 14 , wherein, in the compound of formula (I), X is strontium or zinc.
29 . A composition according to claim 1 , wherein, in the compound of formula (I), R and R′ are methyl radicals.
30 . A composition according to claim 15 , wherein, in the compound of formula (I), R and R′ are methyl radicals.
31 . The composition according to claim 1 , wherein said at least one compound of formula (I) is selected from the group consisting of strontium 2,4-pentanedionate, bis(1,1,1,2,2,3,3-heptafluoro-7,7-dimethyl-4,6-octanedionato)strontium hydrate, bis(2,2,6,6-tetramethyl-3,5-heptanedionato)strontium hydrate and strontium hexafluoroacetylacetonate and mixtures thereof.
32 . A topically applicable cosmetic/dermatological composition for substantially inhibiting or reducing mammalian skin irritation, comprising an irritant amount of at least one normally skin-irritating active species/product and an anti-irritant effective amount of at least one compound having the formula (I):
in which the radicals R, which may be identical or different, are each a linear or branched, saturated or unsaturated, optionally hydroxylated alkyl or perfluoroalkyl radical having from 1 to 12 carbon atoms; the radicals R′, which may be identical or different, are each a linear or branched, saturated or unsaturated, optionally hydroxylated alkyl, alkoxy or perfluoroalkyl radical having from 1 to 12 carbon atoms; and X is magnesium, strontium, barium, zinc, manganese or palladium, said compound being in hydrated or nonhydrated form, and a topically applicable, physiologically acceptable medium therefor.
33 . A composition according to claim 32 , wherein, in the compound of formula (I), each radical R is a linear or branched, saturated alkyl or perfluoroalkyl radical having from 1 to 6 carbon atoms.
34 . A composition according to claim 32 , wherein, in the compound of formula (I), each radical R′ is a linear or branched, saturated alkyl, alkoxy or perfluoroalkyl radical having from 1 to 6 carbon atoms.
35 . A composition according to claim 32 , wherein, in the compound of formula (I), the substituents R and R′ are linear.
36 . A composition according to claim 32 , wherein, in the compound of formula (I), the substituents R and R′ are saturated.
37 . A composition according to claim 32 , wherein, in the compound of formula (I), the substituents R and R′ comprise a difference of at most two carbon atoms with respect to each other.
38 . A composition according to claim 32 , wherein, in the compound of formula (I), X is strontium or zinc.
39 . A composition according to claim 32 , wherein, in the compound of formula (I), R and R′ are methyl radicals.
40 . A composition according to claim 38 , wherein, in the compound of formula (I), R and R′ are methyl radicals.
41 . The composition according to claim 32 , wherein said at least one compound of formula (I) is selected from the group consisting of strontium 2,4-pentanedionate, bis(1,1,1,2,2,3,3-heptafluoro-7,7-dimethyl-4,6-octanedionato)strontium hydrate, bis(2,2,6,6-tetramethyl-3,5-heptanedionato)strontium hydrate and strontium hexatluoroacetylacetonate and mixtures thereof.
42 . A composition according to claim 32 , wherein said at least one normally skin-irritating active species/product is selected from the group consisting of a preservative, surfactant, fragrance, solvent, propellant, active agent, and mixtures thereof.
43 . A composition according to claim 32 , wherein said at least one normally skin-irritating active species/product is selected from the group consisting of a sunscreen, hydroxy acid, keto acid, retinoid, anthralin, anthranoid, peroxide, minoxidil, lithium salt, antiproliferating agent, vitamin, hair tint, hair dye, perfuming alcoholic solution, antiperspirant, hair-removing active agent, permanent-waving active agent, depigmenting agent, capsaicin, antilouse active agent, ionic detergent agent, nonionic detergent agent, propigmenting agent and mixtures thereof.
44 . A composition according to claim 32 , wherein said at least one normally skin-irritating active species/product is selected from the group consisting of an α-hydroxy acid, a β-hydroxy acid, an α-keto acid, a β-keto acid, 5-fluorouracil, methothrexate, vitamin B9, vitamin D or a derivative thereof and mixtures thereof.
45 . A composition according to claim 32 , wherein said at least one normally skin-irritating active species/product is a p-hydroxy acid.
46 . A composition according to claim 32 , wherein said at least one normally skin-irritating active species/product is salicylic acid or a derivative thereof.
47 . A composition according to claim 32 , wherein said at least one normally skin-irritating active species/product is selected from the group consisting of 5-n-octanoylsalicylic acid, 5-n-dodecanoylsalicylic acid, a salt thereof, and an ester thereof.
48 . A composition according to claim 1 , which is in liquid form.
49 . A composition according to claim 1 , which is selected from the group consisting of an oily solution, gel, anhydrous liquid, anhydrous solid, anhydrous paste, emulsion, microemulsion, vesicular dispersion, cream, lotion, milk, ointment, serum, mousse, aerosol, stick, makeup, shampoo and soap.
50 . A composition according to claim 49 , which is other than a cream or soap.
51 . A composition according to claim 32 , which is in liquid form.
52 . A composition according to claim 32 , which is selected from the group consisting of an oily solution, gel, anhydrous liquid, anhydrous solid, anhydrous paste, emulsion, microemulsion, vesicular dispersion, cream, lotion, milk, ointment, serum, mousse, aerosol, stick, makeup, shampoo and soap.
53 . A composition according to claim 52 , which is other than a cream or soap.
54 . A composition according to claim 1 , wherein said at least one compound of formula (I) is present in an amount of from 0.001% to 30% by weight of the total weight of the composition.
55 . A composition according to claim 1 , wherein said at least one compound of formula (I) is present in an amount of from 0.01% to 20% by weight of the total weight of the composition.
56 . A composition according to claim 1 , wherein said at least one compound of formula (I) is present in an amount of from 0.1% to 10% by weight of the total weight of the composition.
57 . A composition according to claim 32 , wherein said at least one compound of formula (I) is present in an amount of from 0.001% to 30% by weight of the total weight of the composition.
58 . A composition according to claim 32 , wherein said at least one compound of formula (I) is present in an amount of from 0.01% to 20% by weight of the total weight of the composition.
59 . A composition according to claim 32 , wherein said at least one compound of formula (I) is present in an amount of from 0.1% to 10% by weight of the total weight of the composition.
60 . A composition according to claim 32 , wherein said at least one normally skin-irritating active species/product is present in an amount of from 5% to 50% by weight of the total weight of the composition.
61 . A composition according to claim 57 , wherein said at least one normally skin-irritating active species/product is present in an amount of from 5% to 50% by weight of the total weight of the composition.
62 . A composition according to claim 58 , wherein said at least one normally skin-irritating active species/product is present in an amount of from 5% to 50% by weight of the total weight of the composition.
63 . A composition according to claim 59 , wherein said at least one normally skin-irritating active species/product is present in an amount of from 5% to 50% by weight of the total weight of the composition.
64 . A composition according to claim 1 , wherein the compound of formula (I) is the product of the reaction of a β-diketone and a hydroxylated or carbonated activated cation.
65 . A composition according to claim 32 , wherein the compound of formula (I) is the product of the reaction of a P-diketone and a hydroxylated or carbonated activated cation.Cited by (0)
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