US2003170714A1PendingUtilityA1

Transcripts encoding immunomodulatory polypeptides

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Assignee: GENELABS TECH INCPriority: Jan 26, 1996Filed: Mar 19, 2003Published: Sep 11, 2003
Est. expiryJan 26, 2016(expired)· nominal 20-yr term from priority
Inventors:Gregory Dolganov
C07K 14/47A01K 2217/05A61K 48/00A61K 38/00
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Claims

Abstract

Substantially-isolated polynucleotides encoding human polypeptides having immunomodulatory activity; human homologs of yeast RAD50, Drosophila Septin-2 and rat Acyl-CoA Synthetase compositions and methods; method for detecting the presence of activated T-cells.

Claims

exact text as granted — not AI-modified
It is claimed:  
     
         1 . A substantially-isolated polynucleotide having a sequence encoding a human polypeptide having immunomodulatory activity, where said polynucleotide contains a sequence selected from the group consisting of SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:76, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:88, SEQ ID NO:92, SEQ ID NO:95, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO:100, SEQ ID NO:104, SEQ ID NO:105, SEQ ID NO:106, SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO:112, SEQ ID NO:113, SEQ ID NO:114, SEQ ID NO:115, SEQ ID NO:124, SEQ ID NO:130, SEQ ID NO:132, SEQ ID NO:133, SEQ ID NO:134, SEQ ID NO:135, SEQ ID NO:136, SEQ ID NO:137 and SEQ ID NO:138.  
     
     
         2 . A polynucleotide of  claim 1  containing a sequence selected from the group represented by SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:76, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:92, SEQ ID NO:95, SEQ ID NO:99, SEQ ID NO:105, SEQ ID NO:106, SEQ ID NO:107, SEQ ID NO:124, SEQ ID NO:130, SEQ ID NO:135, SEQ ID NO:136, SEQ ID NO:137 and SEQ ID NO:138.  
     
     
         3 . A polynucleotide of  claim 2  containing a sequence selected from the group represented by SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ ID N0:76, SEQ ID NO:78 and SEQ ID NO:79.  
     
     
         4 . A substantially-isolated human polypeptide having immunomodulatory activity, where said polypeptide has a sequence encoded by a polynucleotide selected from the group consisting of SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:76, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:88, SEQ ID NO:92, SEQ ID NO:95, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO:100, SEQ ID NO:104, SEQ ID NO:105, SEQ ID NO:106, SEQ ID NO:107, SEQ ID NO:108, SEQ ID NO:109, SEQ ID NO:112, SEQ ID NO:113, SEQ ID NO:114, SEQ ID NO:115, SEQ ID NO:124, SEQ ID NO:130, SEQ ID NO:132, SEQ ID NO:133, SEQ ID NO:134, SEQ ID NO:135, SEQ ID NO:136, SEQ ID NO:137 and SEQ ID NO:138.  
     
     
         5 . A polypeptide of  claim 4 , where said polypeptide has a sequence encoded by a polynucleotide selected from the group consisting of SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:76, SEQ ID NO:85, SEQ ID NO:86, SEQ ID NO:92, SEQ ID NO:95, SEQ ID NO:99, SEQ ID NO:105, SEQ ID NO:106, SEQ ID NO:107, SEQ ID NO:124, SEQ ID NO:130, SEQ ID NO:135, SEQ ID NO:136, SEQ ID NO:137 and SEQ ID NO:138.  
     
     
         6 . A polypeptide of  claim 4 , where said polypeptide has a sequence encoded by a polynucleotide selected from the group consisting of SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ ID NO:76, SEQ ID NO:78 and SEQ ID NO:79.  
     
     
         7 . A substantially-isolated polynucleotide having a sequence encoding a human homologue of yeast RAD50.  
     
     
         8 . A polynucleotide of  claim 7  containing a sequence selected from the group consisting of SEQ ID NO:54 and SEQ ID NO:55.  
     
     
         9 . A substantially-isolated human homolog of yeast RAD50 polypeptide.  
     
     
         10 . A polypeptide of  claim 9  containing a polypeptide sequence encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NO:54 and SEQ ID NO:55.  
     
     
         11 . A substantially-isolated polynucleotide having a sequence encoding a human homologue of  Drosophila melanogaster  Septin-2.  
     
     
         12 . A polynucleotide of  claim 11  containing a sequence represented by SEQ ID NO:97.  
     
     
         13 . A substantially-isolated human Septin-2 homolog polypeptide.  
     
     
         14 . A polypeptide of  claim 13  containing a polypeptide sequence encoded by the polynucleotide sequence represented by SEQ ID NO:97.  
     
     
         15 . A method of identifying the presence of activated T-cells in a sample containing a plurality of different cell types, comprising 
 performing a polymerase chain reaction amplification, where an aliquot of said sample serves as an amplification target and where said amplification is done using an oligonucleotide primer pair capable of selective amplification of a polynucleotide fragment having the sequence represented as SEQ ID NO:151, to generate an amplification product having a specific size, and    determining the size of the amplification product,    wherein presence of amplification product of an expected size is indicative of the presence of activated T cells in the sample.    
     
     
         16 . A method of  claim 15 , where said primer pair consists of primers having sequences represented as SEQ ID NO:149 and SEQ ID NO:150.  
     
     
         17 . A method of  claim 15 , where said sample is from adult tissue.

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