Identification of antigenic peptide sequences

Abstract

Identification of linear amino acid antigenic sequences for the production of both polyclonal and monoclonal antibodies to defined antigenic domains is described. Also described are antigenic peptides identified by the described methods and antibodies thereto.

1 . A substantially pure immunogenic polypeptide having a sequence consisting essentially of SEQ ID NO: 81 or a subsequence of SEQ ID NO: 81 that comprises amino acids 2 to 13 of SEQ ID NO: 101.  
     
     
         2 . The substantially pure immunogenic polypeptide of  claim 1 , wherein said sequence consists essentially of SEQ ID NO: 81 or amino acids 2 to 13 of SEQ ID NO: 101.  
     
     
         3 . A substantially pure nucleic acid encoding an immunogenic polypeptide having a sequence consisting essentially of SEQ ID NO: 81 or a subsequence of SEQ ID NO: 81 that comprises amino acids 2 to 13 of SEQ ID NO: 101.  
     
     
         4 . The substantially pure nucleic acid of claim  6 , wherein said sequence consists essentially of SEQ ID NO: 81 or amino acids 2 to 13 of SEQ ID NO: 101.  
     
     
         5 . A substantially pure antibody that specifically binds to a polypeptide having a sequence consisting essentially of SEQ ID NO: 81 or a subsequence of SEQ ID NO: 81 that comprises amino acids 2 to 13 of SEQ ID NO: 101.