Intraocular lens and process for the production of one-piece intraocular lens

Abstract

A one-piece intraocular lens having an optic portion and a haptic portion, the optic portion being formed of a copolymer obtained by copolymerization of predetermined amounts of 2-[2-(perfluorooctyl)ethoxy]-1-methylethyl (meth)acrylate, 2-phenylethyl (meth)acrylate, alkyl (meth)acrylate and a crosslinking monomer, the haptic portion being formed of polymethyl methacrylate, a process for the production thereof, and a soft intraocular lens having an optic portion and a haptic portion formed of a soft material, the haptic portion having a bendable portion having specific functions, the one-piece intraocular lens being insertable into an eye through a small incision with the optic portion being bent, the soft intraocular lens permitting the prevention of the deformation of the soft optic portion caused by the shrink of a capsule when the soft intraocular lens is inserted into an eye.

What is claimed is:  
     
         1 . A one-piece intraocular lens having an optic portion which functions as a substitute lens for a crystalline lens and a haptic portion for fixing and holding the optic portion in a predetermined position in an eye, the optic portion being formed of a copolymer obtained by polymerization of a monomer mixture containing 
 (a) 5 to 20% by weight of 2-[2-(perfluorooctyl)ethoxy]-1-methylethyl (meth)acrylate of the formula (I),                          wherein R 1  is hydrogen or methyl,    (b) 40 to 70% by weight of 2-phenylethyl (meth)acrylate of the formula (II),                          wherein R 2  is hydrogen or methyl,    (c) 25 to 50% by weight of alkyl (meth)acrylate of the formula (III),                          wherein R 3  is hydrogen or methyl and R 4  is a C 4 -C 12  linear, branched or cyclic alkyl group, and    (d) 0.5 to 5% by weight, based on the total amount of the components (a) to (c), of a crosslinking monomer,    the haptic portion being formed of polymethyl methacrylate.    
     
     
         2 . The one-piece intraocular lens of  claim 1 , wherein the optic portion has deformable softness.  
     
     
         3 . The one-piece intraocular lens of  claim 1 , wherein the optic portion and the haptic portion have a junction portion formed of an interpenetrating network structure.  
     
     
         4 . A process for the production of a one-piece intraocular lens having an optic portion which functions as a substitute lens for a crystalline lens and a haptic portion for fixing and holding the optic portion in a predetermined position in an eye, the process comprising polymerizing an optic-portion-forming monomer mixture containing 
 (a) 5 to 20% by weight of 2-[2-(perfluorooctyl)ethoxy]-1-methylethyl (meth)acrylate of the above formula (I),                          wherein R 1  is hydrogen or methyl,    (b) 40 to 70% by weight of 2-phenylethyl (meth)acrylate of the formula (II),                          wherein R 2  is hydrogen or methyl,    (c) 25 to 50% by weight of alkyl (meth)acrylate of the formula (III),                          wherein R 3  is hydrogen or methyl and R 4  is a C 4 -C 12  linear, branched or cyclic alkyl group, and    (d) 0.5 to 5% by weight, based on the total amount of the components (a) to (c), of a crosslinking monomer, with keeping the monomer mixture in contact with a haptic-portion-forming material containing polymethyl methacrylate, or polymerizing a haptic-portion-forming monomer containing methyl methacrylate with keeping the haptic-portion-forming monomer in contact with an optic-portion-forming material formed of a copolymer obtained by polymerization of the above monomer mixture, to integrate the optic-portion-forming material and the haptic-portion-forming material, and cutting and polishing the integrated product.    
     
     
         5 . The process of  claim 4 , wherein a disc which is formed of polymethyl methacrylate and has a cylindrical concave portion having predetermined dimensions is provided and the monomer mixture is charged in the cylindrical concave portion and polymerized.  
     
     
         6 . The process of  claim 4 , wherein the cutting and polishing are carried out with cooling.  
     
     
         7 . A soft intraocular lens having an optic portion formed of a deformable soft material which functions as a substitute lens for a crystalline lens and a haptic portion which is formed of arm-like members extending outwardly from circumferential portions of the optic portion and is for fixing and holding the optic portion in a predetermined position in an eye, the haptic portion being provided with a bendable portion which, when a compressive force is externally exerted on the haptic portion so as to move at least any site of the haptic portion toward the optic portion, can absorb at least part of the external compressive force by deformation and decreases the force to be transmitted to the optic portion.  
     
     
         8 . The soft intraocular lens of  claim 7 , wherein the force to be transmitted to the optic portion is a force to move the optic portion in a direction in parallel with an optical axis of the optic portion and the bendable portion absorbs at least part of the force by undergoing deformation.  
     
     
         9 . The soft intraocular lens of  claim 7 , wherein the above haptic portion is formed so as to form a first angle with a plane at right angles with the optical axis of the above optic portion as the haptic portion extends outwardly from its start portion in the vicinity of the above optic portion, and the haptic portion has a first bendable portion which is bent so as to form a second angle, an angle opposite to the above first angle, with a plane at right angles with the optical axis of the optic portion in a position located outside the above start portion of the haptic portion and a second bendable portion which is bent so as to form a third angle, an angle opposite to the above second angle, with a plane at right angles with the optical axis of the above optic portion in a position located outside the first bendable portion.  
     
     
         10 . The soft intraocular lens of  claim 9 , wherein the first angle is 12 degrees or less.  
     
     
         11 . The soft intraocular lens of  claim 9 , wherein the a distance from the start portion of the haptic portion to the first bendable portion is 3 mm or less.  
     
     
         12 . The soft intraocular lens of  claim 7 , wherein the optic portion and the haptic portion are integrally formed.  
     
     
         13 . The soft intraocular lens of  claim 7 , wherein the haptic portion is formed of a hard material having a higher hardness than a soft material forming the optic portion.