Aqueous pharmaceutical compositions

Abstract

The present invention has an object to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when new quinolone antibacterial agents such as ofloxacin as the active ingredient and can be retained at the administration site for a long time by virtue of rapid viscosity increase after administration in spite of their being liquid at administration and thereby attain high availability of pharmaceutical agent. The present invention relates to an antibacterial aqueous pharmaceutical composition which comprises: 2.8 to 4 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa.s or below at 20° C.; 1.5 to 2.3 w/v % of citric acid; 2 to 4 w/v % of polyethylene glycol; and 0.1 to 0.5 w/v % of ofloxacin.

1 . An antibacterial aqueous pharmaceutical composition 
 which comprises: 2.8 to 4 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa.s or below at 20° C.; 1.5 to 2.3 w/v % of citric acid; 2 to 4 w/v % of polyethylene glycol; and 0.1 to 0.5 w/v % of ofloxacin.    
     
     
         2 . An antibacterial aqueous pharmaceutical composition 
 which comprises: 2.8 to 4 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa.s or below at 20° C.; 1.5 to 2.3 w/v % of citric acid; 2 to 4 w/v % of polyethylene glycol; and 0.1 to 0.5 w/v % of at least one kind of new quinolone antibacterial agent selected from the group consisting of ofloxacin, levofloxacin and moxifloxacin hydrochloride.    
     
     
         3 . An aqueous pharmaceutical composition 
 which comprises: 2.3 to 8 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa.s or below at 20° C.; 0.14 to 4 w/v % of at least one kind of acid selected from the group consisting of multivalent carboxylic acid, lactic acid and gluconic acid; and an effective amount of a pharmaceutical agent.    
     
     
         4 . An aqueous pharmaceutical composition 
 which comprises: 2.3 to 8 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa.s or below at 20° C.; 0.5 to 13 w/v % of polyethylene glycol; and an effective amount of a pharmaceutical agent.    
     
     
         5 . An aqueous pharmaceutical composition 
 which comprises: 2.3 to 8 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has the viscosity of 12 mPa.s or below at 20° C.; 0.14 to 4 w/v % of at least one kind of acid selected from the group consisting of multivalent carboxylic acid, lactic acid and gluconic acid; 0.5 to 13 w/v % of polyethylene glycol; and an effective amount of a pharmaceutical agent.