Preventatives/remedies for skin aging

Abstract

A composition for prophylaxis and therapy of dermal aging which comprises a substance having human leukocyte elastase inhibitory activity as an active ingredient.

1 . A composition for prophylaxis and therapy of dermal aging which comprises a substance having human leukocyte elastase inhibitory activity as an active ingredient.  
     
     
         2 . A composition for prophylaxis and therapy of wrinkles which comprises WS7622A mono- or disulfate ester or a pharmaceutically acceptable salt thereof as an active ingredient.  
     
     
         3 . A composition for prophylaxis and therapy of dermal aging which comprises a trifluoromethylketone derivative of the following formula or a pharmaceutically acceptable salt thereof as an active ingredient.  
       
         
           
           
               
               
           
         
       
       [wherein R 1  represents a lower alkyl group having 1 or 2 substituents selected from among carboxy, esterified carboxy and di-lower alkylcarbamoyl; a phenyl (lower) alkyl group which may optionally have halogen, amino or nitro on the phenyl moiety thereof and carboxy or esterified carboxy on the alkyl moiety thereof; a halophenyl group; a morpholino group; or a morpholino (lower) alkyl group; R 2  and R 3  each represents a lower alkyl group; X represents— or —NH—;  
       
         
           
           
               
               
           
         
       
     
     
         4 . A composition for prophylaxis and therapy of wrinkles which comprises a trifluoromethylketone derivative of the following formula or a pharmaceutically acceptable salt thereof as an active ingredient.  
       
         
           
           
               
               
           
         
       
       [wherein R 1  represents a lower alkyl group having 1 or 2 substituents selected from among carboxy, esterified carboxy and di-lower alkylcarbamoyl; a phenyl (lower) alkyl group which may optionally have halogen, amino or nitro on the phenyl moiety thereof and carboxy or esterified carboxy on the alkyl moiety thereof; a halophenyl group; a morpholino group; or a morpholino (lower) alkyl group; R 2  and R 3  each represents a lower alkyl group; X represents— or —NH—;  
       
         
           
           
               
               
           
         
       
     
     
         5 . The composition for prophylaxis and therapy of dermal aging as claimed in  claim 1  wherein the substance having human leukocyte elastase inhibitory activity is Substance FR134043.  
     
     
         6 . The composition for prophylaxis and therapy of wrinkles as claimed in  claim 2  wherein the substance having human leukocyte elastase inhibitory activity is Substance FR134043.  
     
     
         7 . The composition for prophylaxis and therapy of dermal aging as claimed in  claim 1  wherein the substance having human leukocyte elastase inhibitory activity is Substance FK706.  
     
     
         8 . The composition for prophylaxis and therapy of wrinkles as claimed in  claim 4  wherein the substance having human leukocyte elastase inhibitory activity is Substance FK706.  
     
     
         9 . A method for prophylaxis and therapy of dermal aging which comprises administering a substance having human leukocyte elastase inhibitory activity to a patient for the prevention or treatment of dermal aging.  
     
     
         10 . Use of a substance having human leukocyte elastase inhibitory activity for the production of a pharmaceutical composition for the prophylaxis and therapy of dermal aging.