Anti peptic ulcer activity of an extract of a plant flower woodfordia fruticosa

Abstract

The present invention provides a pharmaceutical composition comprising an effective amount of an extract or lyophilized extract or at least one bioactive fraction obtained from plant woodfordia ftuticosa along with one or more pharmaceutically acceptable additives/carriers for treating ulcer caused by the conditions such as stress induced ulcer, peptic ulcer, cold restraint induced ulcer, drug induced ulcer and acid induced ulcer, also used as specific inhibitor of gastric H + ,K + -ATPase and anti- Helicobacter pylori activity.

What is claimed is:  
     
         1 . A pharmaceutical composition comprising an effective amount of an extract or lyophilized extract or at least one bioactive fraction obtained from plant  woodfordia ftuticosa  along with one or more pharmaceutically acceptable additives/carriers.  
     
     
         2 . The composition as claimed in  claim 1 , wherein said composition is administered to treat ulcer caused by the conditions selected from stress induced ulcer, peptic ulcer, cold restraint induced ulcer, drug induced ulcer and acid induced ulcer.  
     
     
         3 . The composition as claimed in  claim 1 , wherein the composition inhibits gastric H + ,K + -ATPase  
     
     
         4 . The composition as claimed in  claim 1 , wherein the composition inhibits  Helicobacter pylori  activity.  
     
     
         5 . The composition as claimed in  claim 1 , wherein the extract is lyophilized aqueous alcoholic extract.  
     
     
         6 . The composition as claimed in  claim 1 , wherein the lyophilized extract is designated as A-002.  
     
     
         7 . The composition as claimed in  claim 1 , wherein amount of extract administered is in the range of 50 to 200 mg/kg body weight/day.  
     
     
         8 . The composition as claimed in  claim 1 , wherein the bioactive fraction is selected from a group consisting of bioactive fractions designated as F-006 and F-007.  
     
     
         9 . The composition as claimed in  claim 1 , wherein amount of bioactive fraction administered is in the range of 20 to 100 mg/kg body weight/day.  
     
     
         10 . The composition as claimed in  claim 1  is administered to mammal including human being.  
     
     
         11 . The composition method as claimed in  claim 1 , wherein the composition can be in the form of tablets, capsules, syrup or by any other form known in the art.  
     
     
         12 . The composition as claimed in  claim 1 , wherein the composition is administered orally, intramuscularly, and by any other conventional methods.  
     
     
         13 . The composition as claimed in  claim 1 , wherein the composition may be used for therapeutic as well as prophylactic treatment of peptic ulcer.  
     
     
         14 . The composition as claimed in  claim 1 , wherein the composition may be administered as a single bolus dose or a multiple doses.  
     
     
         15 . A method of treating a subject for ulcers and related diseases, said method comprises administering an effective amount of a pharmaceutical composition comprising extract or bioactive fractions obtained from plant  woodfordia ftuticosa  along with one or more pharmaceutically acceptable additives/carriers.  
     
     
         16 . A method as claimed in  claim 15 , wherein the composition is administered to treat ulcer caused by the conditions selected from stress induced ulcer, peptic ulcer, cold restraint induced ulcer, drug induced ulcer and acid induced ulcer.  
     
     
         17 . A method as claimed in  claim 15 , wherein the composition is used for inhibiting gastric H + , K + -ATPase activity.  
     
     
         18 . A method as claimed in  claim 15 , wherein the composition inhibits  Helicobacter pylori  activity.  
     
     
         19 . A method as claimed in  claim 15 , wherein the subject is a mammal including human being.  
     
     
         20 . A method as claimed in  claim 15 , wherein amount of extract administered is in the range of 50 to 200 mg/kg body weight/day.  
     
     
         21 . A method as claimed in  claim 15 , wherein the extract administered is lyophilized aqueous alcoholic extract.  
     
     
         22 . A method as claimed in  claim 21 , wherein the lyophilized extract is designated as A-002.  
     
     
         23 . A method as claimed in  claim 15 , wherein amount of bioactive fraction administered is in the range of 20 to 100 mg/kg body weight/day.  
     
     
         24 . A method as claimed in  claim 23 , wherein the bioactive fraction used is designated as F-006 and F-007.  
     
     
         25 . The method as claimed in  claim 15 , wherein the bioactive fraction is used either individually or mixture thereof.  
     
     
         26 . A method as claimed in  claim 15 , wherein the composition can be in the form of tablets, capsules, syrup or by any other form known in the art.  
     
     
         27 . A method as claimed in  claim 15 , wherein the composition is administered orally, intramuscularly, and by any other conventional methods.  
     
     
         28 . A method as claimed in  claim 15 , wherein the composition may be used for therapeutic as well as prophylactic treatment of peptic ulcer.  
     
     
         29 . A method as claimed in  claim 15 , wherein the subject may be administered a single bolus dose or a multiple dose.