US2004033187A1PendingUtilityA1

Bioactive sol-gel derived silica fibers, methods for their preparation and their use

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Priority: Dec 1, 1999Filed: Apr 11, 2003Published: Feb 19, 2004
Est. expiryDec 1, 2019(expired)· nominal 20-yr term from priority
Inventors:Timo PeltolaMika JokinenSinikka VeittolaAntti Yli-Urpo
C04B 35/6224A61L 27/025C04B 2235/441D01F 9/08A61L 31/028C03B 37/011C04B 35/624C03B 37/10
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Claims

Abstract

This invention relates to bioactive sol-gel derived silica fibers, methods for their preparation, an implantable device comprising said fibers and the use of said device for tissue guiding or bone repair.

Claims

exact text as granted — not AI-modified
1 . A method for the preparation of a bioactive sol-gel derived silica fiber, said method comprising spinning the fiber from a silica sol wherein the starting point of the spinning process corresponds to a sol viscosity of at least 2000 cP, followed by i) heat treating or ii) aging of the fiber.  
     
     
         2 . The method according to  claim 1  wherein the viscosity is at least 3000 cP.  
     
     
         3 . The method according to  claim 1  wherein the fiber is heat treated for a sufficient period of time in a temperature in the range 150 to 250° C.  
     
     
         4 . The method according to  claim 3  wherein the temperature range is 150 to 200° C., preferably about 175° C.  
     
     
         5 . The method according to  claim 2  wherein the fiber is heat treated for a sufficient period of time in a temperature in the range 150 to 250° C.  
     
     
         6 . The method according to  claim 5  wherein the temperature range is 150 to 200° C., preferably about 175° C.  
     
     
         7 . The method according to  claim 1  wherein the fiber is aged for about 2 weeks to 5 months.  
     
     
         8 . The method according to  claim 7  wherein the fiber is aged for about 3 to 5 months.  
     
     
         9 . The method according to  claim 2  wherein the fiber is aged for about 2 weeks to 5 months.  
     
     
         10 . The method according to  claim 9  wherein the fiber is aged for about 3 to 5 months.  
     
     
         11 . A bioactive sol-gel derived silica fiber spun from a sol at a starting point of the spinning process corresponding to a sol viscosity of at least 2000 cP, after which said fiber has been subjected to i) heat treatment or ii) aging.  
     
     
         12 . The fiber according to  claim 11  wherein said viscosity is at least 3000 cP.  
     
     
         13 . The fiber according to  claim 11  wherein said fiber has been heat treated for a sufficient period of time in a temperature in the range 150 to 250° C.  
     
     
         14 . The fiber according to  claim 13 , said fiber having been heat treated in the temperature range 150 to 200° C., preferably about 175° C.  
     
     
         15 . The fiber according to  claim 12  wherein said fiber has been heat treated for a sufficient period of time in a temperature in the range 150 to 250° C.  
     
     
         16 . The fiber according to  claim 15 , said fiber having been heat treated in the temperature range 150 to 200° C., preferably about 175° C.  
     
     
         17 . The fiber according to  claim 11  wherein said fiber has been aged for about 2 weeks to 5 months.  
     
     
         18 . The fiber according to  claim 17  wherein said fiber has been aged for about 3 to 5 months.  
     
     
         19 . The fiber according to  claim 12  wherein said fiber has been aged for about 2 weeks to 5 months.  
     
     
         20 . The fiber according to  claim 19  wherein said fiber is aged for about 3 to 5 months.  
     
     
         21 . The fiber according to any of the  claims 11  to  20  wherein said fiber also comprises a biologically active agent.  
     
     
         22 . An implantable device comprising a fiber according to any one of the  claims 11  to  20 .  
     
     
         23 . An implantable device comprising a mixture of two or more kinds of fibers according to any one of the  claims 11  to  20 .  
     
     
         24 . The device according to  claim 22  in the form or a woven or non-woven mat, a knitted fabric or a braided cord.  
     
     
         25 . The device according to  claim 23  in the form or a woven or non-woven mat, a knitted fabric or a braided cord.  
     
     
         26 . An implantable device comprising a fiber according to a any of the  claims 11  to  20  wherein said fiber also comprises a biologically active agent.  
     
     
         27 . An implantable device comprising a mixture of two or more kinds of fibers according to any of the  claims 11  to  20 , wherein one of more kinds of fibers also contain a biologically active agent.  
     
     
         28 . A method of using a device according to  claim 22  for tissue guiding or bone repair.  
     
     
         29 . A method of using a device according to  claim 26  for tissue guiding or bone repair.

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