Compositions and methods for alleviating hypertension or preventing a rise in blood pressure

Abstract

Products and compositions for preventing or reducing the severity of hypertension. These products contain (a). ferulic acid or a ferulate ester, and (b) caffeic acid and/or a chlorogenic acid. The preventive or remedy can suppress a rise in blood pressure and alleviate hypertension, and is usable as a food.

1 . A composition comprising: 
 (a) ferulic acid or an ester thereof, or a pharmaceutically acceptable salt thereof, and    (b) caffeic acid and/or a chlorogenic acid, or a pharmaceutically acceptable salt thereof.    
     
     
         2 . The composition of  claim 1 , wherein (b) consists of caffeic acid or a pharmaceutically acceptable salt thereof.  
     
     
         3 . The composition of  claim 1 , wherein (b) consists of a chlorogenic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         4 . The composition of  claim 3 , wherein the chlorogenic acid is selected from the group consisting of: neochlorogenic acid, an isochlorogenic acid, 3,5-dicaffeoylquinic acid, cryptochlorogenic acid and 5-caffeoylquinic acid.  
     
     
         5 . The composition of  claim 1 , wherein (b) comprises caffeic acid and a chlorogenic acid, or pharmaceutically acceptable salts thereof.  
     
     
         6 . A food or beverage comprising: 
 (a) ferulic acid or an ester thereof, or a pharmaceutically acceptable salt thereof, and    (b) caffeic acid and/or a chlorogenic acid, or a pharmaceutically acceptable salt thereof.    
     
     
         7 . The food or beverage of  claim 6 , selected from the group consisting of a milk product, a cereal or pasta product, a soy product, a rice product, a wheat flour product, an oil or fat-containing food, a condiment, a semisolid food, a sauce, a soup, coffee, decaffeinated coffee, tea, decaffeinated tea, a herbal tea or infusion, a chocolate product, a beverage containing alcohol, a fruit or vegetable juice and a soft drink.  
     
     
         8 . A supplement comprising ferulic acid or an ester thereof, or a pharmaceutically acceptable salt thereof, and caffeic acid and/or a chlorogenic acid, or pharmaceutically acceptable salts thereof.  
     
     
         9 . The supplement of  claim 8 , further comprising a nutrient, vitamin, mineral, herbal product or drug.  
     
     
         10 . The supplement of  claim 8  in the form of a tablet, granule, fine subtilae, pill, powder, capsule, troche, medicinal drink, solution for injection, suppository, or dermatological preparation.  
     
     
         11 . A process for preventing or treating hypertension or high blood pressure comprising: administering an effective dose of a composition comprising (a) ferulic acid or an ester thereof, or a pharmaceutically acceptable salt thereof, and (b) a component selected from caffeic acid and/or a chlorogenic acid, or a pharmaceutically acceptable salt thereof, to a subject in need thereof.  
     
     
         12 . The process of  claim 11 , wherein systolic blood pressure is reduced.  
     
     
         13 . The process of  claim 11 , wherein diastolic blood pressure is reduced.  
     
     
         14 . A method for reducing a rise in blood pressure comprising administering an effective dosage of a composition comprising: (a) ferulic acid or an ester thereof, or a pharmaceutically acceptable salt thereof, and (b) a component selected from caffeic acid and/or a chlorogenic acid, or a pharmaceutically acceptable salt thereof, to a subject in need thereof.  
     
     
         15 . The process of  claim 14 , wherein the rise of systolic blood pressure is reduced.  
     
     
         16 . The process of  claim 14 , wherein the rise in diastolic blood pressure is reduced.  
     
     
         17 . A food or beverage supplemented with ferulic acid, or a pharmaceutically acceptable salt thereof.  
     
     
         18 . A food or beverage supplemented with caffeic acid or a pharmaceutically acceptable salt thereof.  
     
     
         19 . A food or beverage supplemented with a chlorogenic acid, or a pharmaceutically acceptable salt thereof.