US2004048932A1PendingUtilityA1

Fluoroether compositions and methods for inhibiting their degradation in the presnce of a lewis acid

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Priority: Jan 27, 1997Filed: Jun 26, 2003Published: Mar 11, 2004
Est. expiryJan 27, 2017(expired)· nominal 20-yr term from priority
Inventors:Christopher BieniarzSteve H. ChangKeith CromackShuyen HuangToshikazu KawaiManami KobayashiDavid LoffredoRajagopalan RaghavanEarl R. SpeicherHonorate Stelmach
A61P 23/00A61K 47/02A61K 31/08A61K 47/14A61K 9/0019A61K 47/10A61K 47/12
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Claims

Abstract

The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . An anesthetic composition comprising a fluoroether compound having an alpha fluoroether moiety having added thereto an effective stabilizing amount of a Lewis acid inhibitor.  
     
     
         2 . The composition of  claim 1  wherein the fluoroether compound is selected from a group consisting of sevoflurane, enflurane, isoflurane, methoxyflurane, and desflurane.  
     
     
         3 . The composition of  claim 1  wherein the Lewis acid inhibitor is selected from a group consisting of water, butylated hydroxytoluene, methylparaben, propylparaben, propofol, and thymol.  
     
     
         4 . The composition of  claim 1  wherein the fluoroether compound is sevoflurane and the Lewis acid inhibitor is water.  
     
     
         5 . The composition of  claim 4  containing at least about 0.04% w/w to about 0.14% w/w of water.  
     
     
         6 . A method of preparing the anesthetic composition of  claim 1  comprising the step of adding the Lewis acid inhibitor to the fluoroether compound.  
     
     
         7 . A method of preparing the anesthetic composition of  claim 1  comprising the step of adding the fluoroether compound to the Lewis acid inhibitor.  
     
     
         8 . A method of stabilizing a fluoroether compound having an alpha fluoroether moiety, the method comprising the step of adding to the fluoroether compound an effective stabilizing amount of a Lewis acid inhibitor to prevent the degradation of the fluoroether compound by the Lewis acid.  
     
     
         9 . The method of  claim 8  wherein the fluoroether compound is selected from a group consisting of sevoflurane, enflurane, isoflurane, methoxyflurane, and desflurane.  
     
     
         10 . The method of  claim 8  wherein the Lewis acid inhibitor is selected from a group consisting of water, butylated hydroxytoluene, methylparaben, propylparaben, propofol and thymol.  
     
     
         11 . The method of  claim 8  wherein the fluoroether compound is sevoflurane and the Lewis acid inhibitor is water.  
     
     
         12 . The method of  claim 11  wherein the amount of water added to the sevoflurane is from about 0.04% w/w to about 0.14% w/w.

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