Antibiotic product, use and formulation thereof

Abstract

An antibiotic product is comprised of at least two dosages forms, each of which has a different release profile, with the C max for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as one or more delayed release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a C max at different times.

What is claimed is:  
     
         1 . A once-a-day antibiotic product comprising: first and second antibiotic dosage forms, each of said antibiotic dosage forms comprising at least one antibiotic and a pharmaceutically acceptable carrier, said first antibiotic dosage form being an immediate release dosage form, said second dosage form being a delayed release dosage form, and wherein each of said first and second antibiotic dosage forms initiates release of said at least one antibiotic at different times and Cmax of the total antibiotic released from said antibiotic product is acheived in less than about 12 hours from administration and said once-a-day antibiotic product contains the total dosage of the at least one antibiotic for a twenty-four hour period.  
     
     
         2 . The product of  claim 1 , wherein the Cmax for the product is reached no earlier than four hours after administration.  
     
     
         3 . The product of  claim 1 , wherein the antibiotic released from the first dosage form reaches a Cmax within from about 0.5 hours to about 2 hours after administration of the product.  
     
     
         4 . The product of  claim 1 , wherein the antibiotic released from the second dosage form reaches a Cmax in no more than about 4 hours after administration of the product.  
     
     
         5 . The product of  claim 1 , wherein the product is an oral dosage form.  
     
     
         6 . The product of  claim 1 , wherein the antibiotic released from the second dosage form reaches a Cmax in the serum after Cmax is reached in the serum for the antibiotic released from the first dosage form.  
     
     
         7 . A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of  claim 1  once-a-day.  
     
     
         8 . A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of  claim 2  once-a-day.  
     
     
         9 . A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of  claim 3  once-a-day.  
     
     
         10 . A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of  claim 4  once-a-day.  
     
     
         11 . A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of  claim 5  once-a-day.  
     
     
         12 . A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of  claim 6  once-a-day.