Compounds and compositions for delivering active agents

Abstract

Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

What is claimed is:  
     
         1 . A compound selected from the group consisting of  
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or salts thereof.  
     
     
         2 . A poly amino acid comprising at least one compound selected from the group consisting of  
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or salts thereof.  
     
     
         3 . A poly amino acid as defined in  claim 2 , comprising a peptide.  
     
     
         4 . A composition comprising 
 a. an active agent; and    b. a compound as defined in  claim 1 .    
     
     
         5 . A composition comprising 
 a. an active agent; and    b. a poly amino acid as defined in  claim 2 .    
     
     
         6 . A composition as defined in  claim 5 , wherein said poly amino acid comprises a peptide.  
     
     
         7 . A composition as defined in  claim 4 , wherein said active agent comprises a biologically active agent.  
     
     
         8 . A composition as defined in  claim 7 , wherein said biologically-active agent is selected from the group consisting of a peptide, a mucopoly-saccharide, a carbohydrate, a lipid, a pesticide, or any combination thereof.  
     
     
         9 . A composition as defined in  claim 8 , wherein said biologically-active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, desferrioxamine (DFO), or any combination thereof.  
     
     
         10 . A composition as defined in  claim 5 , wherein said active agent comprises a biologically active agent.  
     
     
         11 . A composition as defined in  claim 10 , wherein said biologically-active agent is selected from the group consisting of a peptide, a mucopoly-saccharide, a carbohydrate, a lipid, a pesticide, or any combination thereof.  
     
     
         12 . A composition as defined in  claim 11 , wherein said biologically-active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, desferrioxamine (DFO), or any combination thereof.  
     
     
         13 . A composition as defined in  claim 6 , wherein said active agent comprises a biologically active agent.  
     
     
         14 . A composition as defined in  claim 13 , wherein said biologically-active agent is selected from the group consisting of a peptide, a mucopoly-saccharide, a carbohydrate, a lipid, a pesticide, or any combination thereof.  
     
     
         15 . A composition as defined in  claim 14 , wherein said biologically-active agent is selected from the group consisting of human growth hormone, bovine growth hormone, growth hormone-releasing hormone, an interferon, interleukin-II, insulin, heparin, calcitonin, erythropoietin, atrial naturetic factor, an antigen, a monoclonal antibody, somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, vasopressin, cromolyn sodium, vancomycin, desferrioxamine (DFO), or any combination thereof.  
     
     
         16 . A dosage unit form comprising 
 (A) a composition according to  claim 4;  and    (B) (a) an excipient, 
 (b) a diluent,  
 (c) a disintegrant,  
 (d) a lubricant,  
 (e) a plasticizer,  
 (f) a colorant,  
 (g) a dosing vehicle, or  
 (h) any combination thereof.  
   
     
     
         17 . A dosage unit form according to  claim 16 , comprising a tablet, a capsule, or a liquid.  
     
     
         18 . A dosage unit form comprising 
 (A) a composition according to  claim 5;  and    (B) (a) an excipient, 
 (b) a diluent,  
 (c) a disintegrant,  
 (d) a lubricant,  
 (e) a plasticizer,  
 (f) a colorant,  
 (g) a dosing vehicle, or  
 (h) any combination thereof.  
   
     
     
         19 . A dosage unit form according to  claim 18 , comprising a tablet, a capsule, or a liquid.  
     
     
         20 . A dosage unit form comprising 
 (A) a composition according to  claim 6;  and    (B) (a) an excipient, 
 (b) a diluent,  
 (c) a disintegrant,  
 (d) a lubricant,  
 (e) a plasticizer,  
 (f) a colorant,  
 (g) a dosing vehicle, or  
 (h) any combination thereof.  
   
     
     
         21 . A dosage unit form according to  claim 20 , comprising a tablet, a capsule, or a liquid.  
     
     
         22 . A method for administering a biologically-active agent to an animal in need of said agent, said method comprising administering orally to said animal a composition as defined in  claim 4 .  
     
     
         23 . A method for administering a biologically-active agent to an animal in need of said agent, said method comprising administering orally to said animal a composition as defined in  claim 5 .  
     
     
         24 . A method for administering a biologically-active agent to an animal in need of said agent, said method comprising administering orally to said animal a composition as defined in  claim 6 .  
     
     
         25 . A method for preparing a composition, said method comprising mixing: 
 (A) at least one biologically-active agent;    (B) at least one compound as defined in  claim 1;  and    (C) optionally a dosing vehicle    
     
     
         26 . A method for preparing a composition, said method comprising mixing: 
 (A) at least one biologically-active agent;    (B) at least one poly amino acid as defined in  claim 2;  and    (C) optionally a dosing vehicle    
     
     
         27 . A method for preparing a composition, said method comprising mixing: 
 (A) at least one biologically-active agent;    (B) at least one peptide as defined in  claim 3;  and    (C) optionally a dosing vehicle.