Hydroxamic acid derivative as inhibitor of the formation of soluble human CD23

Abstract

A compound of formula (I) wherein: R is isopropyl; n is 0; R 1 is naphthylmethyl; R 2 is t-butyl; and R 3 is methyl; is useful in the treatment of disorders mediated by s-CD23.

1 . A compound of formula (I):  
       
         
           
           
               
               
           
         
       
       wherein: 
 R is isopropyl;  
 n is 0;  
 R 1  is naphthylmethyl;  
 R 2  is t-butyl; and  
 R 3  methyl.  
 
     
     
         2 . A compound according to  claim 1 , which is a compound of formula (IA):  
       
         
           
           
               
               
           
         
       
     
     
         3 . The use of a compound according to  claim 1  or  claim 2  for the production of a medicament for the treatment or prophylaxis of disorders such as allergy, inflammatory disorders and autoimmune disease in which the overproduction of s-CD23 is implicated.  
     
     
         4 . A method for the treatment or prophylaxis of disorders such as allergy, inflammatory disorders and autoimmune disease in which the overproduction of s-CD23 is implicated, which method comprises the administration of a compound according to  claim 1  or  claim 2  to a human or non-human mammal in need thereof.  
     
     
         5 . A pharmaceutical composition for the treatment or prophylaxis of disorders such as allergy, inflammatory disorders and autoimmune disease in which the overproduction of s-CD23 is implicated which comprises a compound according to  claim 1  or  claim 2  and optionally a pharmaceutically acceptable carrier therefor.  
     
     
         6 . A process for preparing a compound according to  claim 1  or  claim 2 , which process comprises: 
 (a) deprotecting a compound of formula (II):  
                     
 wherein X is a protecting group such as benzyl or trimethylsilyl or  
 (b) reacting a compound of formula (III):  
                     
 wherein the hydroxy group is optionally protected, with hydroxylamine or a salt thereof.  
 
     
     
         7 . A compound of formula (II) as defined in  claim 6 .  
     
     
         8 . A compound of formula (III) as defined in  claim 6.