Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Abstract

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

We claim:  
     
         1 . A pharmaceutical composition capable of treating a NHR-associated condition, comprising a compound of the following formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier:  
       
         
           
           
               
               
           
         
       
       where the symbols have the following meanings, and are, for each occurrence, independently selected: 
 G is a cycloalkenyl, aryl or heterocyclo (e.g., heteroaryl) group, where said group is mono- or polycyclic, and which is optionally substituted at one or more positions, preferably with hydrogen, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, halo, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, aryl or substituted aryl, heterocyclo or substituted heterocyclo, arylalkyl or substituted arylalkyl, heterocycloalkyl or substituted heterocycloalkyl, CN, R 1 OC═O, R 1 C═O—O—, R 1 C═O, R 1 C═S, R 1 HNC═O, R 1 R 2 NC═O, HOCR 3 R 3′ , nitro, R 1 OCH 2 , R 1 O, NH 2 , NR 4 R 5 , SR 1 , S═OR 1 , SO 2 R 1 , SO 2 OR 1′ , SO 2 NR 1 R 1′ , (R 1 O)(R 1′ O)P═O, oxo, (R 1 )(R 1 ′)P═O, or (R 1′ )(NHR 1 )P═O;  
 Z 1  is O, S, NH, or NR 6 ;  
 Z 2  is O, S, NH, or NR 6 ; and  
 (i) Y is J—J′—J″ where J is (CR 7 R 7′ )n and n=0-3, J′ is a bond, C═O, CR 7 R 7′ , C═CR 8 R 8′ , R 2 P═O, R 2 P═S, R 2 OP═O, R 2  NHP═O, OP═OR 2 , C═NR 7 , cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo or aryl or substituted aryl, and J″ is (CR 7 R 7′ )n and n=0-3, where Y is not a bond;  
 W is CR 7 R 7′ —CR 7 R 7′ , CR 8 ═CR 8′ , CR 7 R 7′ —C═O ′ , cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, or aryl or substituted aryl;  
 A 1  is CR 7  or N; and  
 A 2  is CR 7  or N; or alternatively  
 (ii) Y is absent;  
 W is CR 7 R 7′ —CR 7 R 7′ , CR 8 ═CR 8′ , CR 7 R 7′ —C═O, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, or aryl or substituted aryl;  
 A 1  is CR 7 R 7′  or NR 7 ; and  
 A 2  is CR 7 R 7′  or NR 7 ; or alternatively  
 (iii) Y is absent; and  
 A 1 , A 2  and W together are —NR 7 —N═N—; and  
 Q 1  is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycloalkyl or substituted heterocycloalkyl, arylalkyl or substituted arylalkyl, alkynyl or substituted alkynyl, aryl or substituted aryl, heterocyclo (e.g., heteroaryl) or substituted heterocyclo (e.g., substituted heteroaryl), halo, CN, R 1 OC═O, R 4 C═O, R 5 R 6 NC═O, HOCR 7 R 7′ , nitro, R 1 OCH 2 , R 1 O, NH 2 , C═OSR 1 , SO 2 R 1  or NR 4 R 5 ;  
 Q 2  is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycloalkyl or substituted heterocycloalkyl, arylalkyl or substituted arylalkyl, alkynyl or substituted alkynyl, aryl or substituted aryl, heterocyclo (e.g., heteroaryl) or substituted heterocyclo (e.g., substituted heteroaryl), halo, CN, R 1 OC═O, R 4 C═O, R 5 R 6 NC═O, HOCR 7 R 7′ , nitro, R 1 OCH 2 , R 1 O, NH 2 , C═OSR 1 , SO 2 R 1  or NR 4 R 5 ;  
 L is a bond, (CR 7 R 7′ )n, NH, NR 5 , NH (CR 7 R 7′ )n, or NR 5 (CR 7 R 7′ )n, where n=0-3;  
 R 1  and R 1′  are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkyalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl;  
 R 2  is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl;  
 R 3  and R 3′  are each independently H, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, halo, CN, hydroxylamine, hydroxamide, alkoxy or substituted alkoxy, amino, NR 1 R 2 , thiol, alkylthio or substituted alkylthio;  
 R 4  is H, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, R 1 C═O, R 1 NHC═O, SO 2 OR 1 , or SO 2 NR 1 R 1′ ;  
 R 5  is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, R 1 C═O, R 1 NHC═O, SO 2 R 1 , SO 2 OR 1 , or SO 2 NR 1 R 1′ ;  
 R 6  is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, CN, OH, OR 1 , R 1 C═O, R 1 NHC═O, SO 2 R 1 , SO 2 OR 1 , or SO 2 NR 1 R 1′ ;  
 R 7  and R 7′  are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, halo, CN, OR 1 , nitro, hydroxylarnine, hydroxylamide, amino, NHR 4 , NR 2 R 5 , NOR 1 , thiol, alkylthio or substituted alkylthio, R 1 C═O, R 1 OC═O, R 1 C═O—O—, R 1 NHC═O, SO 2 R 1 , SOR 1 , PO 3 R 1 R 1′ , R 1 R 1′ NC═O, C═OSR 1 , SO 2 R 1 , SO 2 OR 1 , or SO 2 NR 1 R 1′ ; and  
 R 8  and R 8′  are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkyalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, nitro, halo, CN, OR 1 , amino, NHR 4 , NR 2 R 5 , NOR 1 , alkylthio or substituted alkylthio, C═OSR 1 , R 1 OC═O, R 1 C═O, R 1 NHC═O, R 1 R 1′ NC═O, SO 2 OR 1 , S═OR 1 , SO 2 R 1 , PO 3 R 1 R 1′ , or SO 2 NR 1 R 1′ .  
 
     
     
         2 . A method of modulating the function of a nuclear hormone receptor which comprises administering to a mammalian species in need thereof an effective nuclear hormone receptor modulating amount of a compound of the following formula I or a pharmaceutically acceptable salt thereof:  
       
         
           
           
               
               
           
         
         where the symbols have the following meanings, and are, for each occurrence, independently selected:  
         G is a cycloalkenyl, aryl or heterocyclo (e.g., heteroaryl) group, where said group is mono- or polycyclic, and which is optionally substituted at one or more positions, preferably with hydrogen, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, halo, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, aryl or substituted aryl, heterocyclo or substituted heterocyclo, arylalkyl or substituted arylalkyl, heterocycloalkyl or substituted heterocycloalkyl, CN, R 1 OC═O, R 1 C═O—O—, R 1 C═O, R 1 C═S, R 1 HNC═O, R 1 R 2 NC═O, HOCR 3 R 3′ , nitro, R 1 OCH 2 , R 1 O, NH 2 , NR 4 R 5 , SR 1 , S═OR 1 , SO 2 R 1 , SO 2 OR 1 , SO 2 NR 1 R 1′ , (R 1 O)(R 1′ O)P═O, oxo, (R 1 )(R 1′ )P═O, or (R 1′ )(NHR 1 )P═O;  
         Z 1  is O, S, NH, or NR 6 ;  
         Z 2  is O, S, NH, or NR 6 ; and  
         (i) Y is J—J′—J″ where J is (CR 7 R 7′ )n and n=0-3, J′ is a bond, C═O, CR 7 R 7′ , C═CR 8 R 8′ , R 2 P═O, R 2 P═S, R 2 OP═O, R 2 NHP═O, OP═OR 2 , C═NR 7 , cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo or aryl or substituted aryl, and J″ is (CR 7 R 7′ )n and n=0-3, where Y is not a bond;  
         W is CR 7 R 7′ —CR 7 R 7′ , CR 8 ═CR 8′ , CR 7 R 7′ —C═O ′ , cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, or aryl or substituted aryl;  
         A 1  is CR 7  or N; and  
         A 2  is CR 7  or N; or alternatively  
         (ii) Y is absent;  
         W is CR 7 R 7′ —CR 7 R 7′ , CR 8 ═CR 8′ , CR 7 R 7′ —C═O, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, or aryl or substituted aryl;  
         A 1  is CR 7 R 7′  or NR 7 ; and  
         A 2  is CR 7 R 7′  or NR 7 ; or alternatively  
         (iii) Y is absent; and  
         A 1 , A 2  and W together are —NR 7 —N═N—; and  
         Q 1  is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycloalkyl or substituted heterocycloalkyl, arylalkyl or substituted arylalkyl, alkynyl or substituted alkynyl, aryl or substituted aryl, heterocyclo (e.g., heteroaryl) or substituted heterocyclo (e.g., substituted heteroaryl), halo, CN, R 1 OC═O, R 4 C═O, R 5 R 1 NC═O, HOCR 7 R 7′ , nitro, R 1 OCH 2 , R 1 O, NH 2 , C═OSR 1 , SO 2 R 1  or NR 4 R 5 ;  
         Q 2  is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycloalkyl or substituted heterocycloalkyl, arylalkyl or substituted arylalkyl, alkynyl or substituted alkynyl, aryl or substituted aryl, heterocyclo (e.g., heteroaryl) or substituted heterocyclo (e.g., substituted heteroaryl), halo, CN, R 1 OC═O, R 4 C═O, R 5 R 6 NC═O, HOCR 7 R 7′ , nitro, R 1 OCH 2 , R 1 O, NH 2 , C═OSR 1 , SO 2 R 1  or NR 4 R 5 ; L is a bond, (CR 7 R 7′ )n, NH, NR 5 , NH (CR 7 R 7′ )n, or NR 5 (CR 7 R 7′ )n, where n=0-3;  
         R 1  and R 1′  are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkyalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl;  
         R 2  is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl;  
         R 3  and R 3′  are each independently H, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, halo, CN, hydroxylamine, hydroxamide, alkoxy or substituted alkoxy, amino, NR 1 R 2 , thiol, alkylthio or substituted alkylthio;  
         R 4  is H, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, R 1 C═O, R 1 NHC═O, SO 2 OR 1 , or SO 2 NR 1 R 1′ ;  
         R 5  is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, R 1 C═O, R 1 NHC═O, SO 2 R 1 , SO 2 OR 1 , or SO 2 NR 1 R 1′ ;  
         R 6  is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, CN, OH, OR 1 , R 1 C═O, R 1 NHC═O, SO 2 R 1 , SO 2 OR 1 , or SO 2 NR 1 R 1′ ;  
         R 7  and R 7′  are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, halo, CN, OR 1 , nitro, hydroxylamine, hydroxylamide, amino, NHR 4 , NR 2 R 5 , NOR 1 , thiol, alkylthio or substituted alkylthio, R 1 C═O, R 1 OC═O, R 1 C═O—O—, R 1 NHC═O, SO 2 R 1 , SOR 1 , PO 3 R 1 R 1′ , R 1 R 1′ NC═O, C═OSR 1 , SO 2 R 1 , SO 2 OR 1 , or SO 2 NR 1 R 1′ ; and  
         R 8  and R 8′  are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkyalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, nitro, halo, CN, OR 1 , amino, NHR 4 , NR 2 R 5 , NOR 1 , alkylthio or substituted alkylthio, C═OSR 1 , R 1 OC═O, R 1 C═O, R 1 NHC═O, R 1 R 1′ NC═O, SO 2 OR 1 , S═OR 1 , SO 2 R 1 , PO 3 R 1 R 1 ′ , or SO 2 NR 1 R 1′ .  
       
     
     
         3 . A method for treating a condition or disorder comprising administering to a mammalian species in need thereof a therapeutically effective amount of a compound of the following formula I or a pharmaceutically acceptable salt thereof:  
       
         
           
           
               
               
           
         
         where the symbols have the following meanings, and are, for each occurrence, independently selected:  
         G is a cycloalkenyl, aryl or heterocyclo (e.g., heteroaryl) group, where said group is mono- or polycyclic, and which is optionally substituted at one or more positions, preferably with hydrogen, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, halo, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, aryl or substituted aryl, heterocyclo or substituted heterocyclo, arylalkyl or substituted arylalkyl, heterocycloalkyl or substituted heterocycloalkyl, CN, R 1 OC═O, R 1 C═O—O—, R 1 C═O, R 1 C═S, R 1 HNC═O, R 1 R 2 NC═O, HOCR 3 R 3′ , nitro, R 1 OCH 2 , R 1 O, NH 2 , NR 4 R 5 , SR 1 , S═OR 1 , SO 2 R 1 , SO 2 OR 1 , SO 2 NR 1 R 1′ , (R 1 O)(R 1′ O)P═O, oxo, (R 1 )(R 1′ )P═O, or (R 1′ )(NHR 1 )P═O;  
         Z 1  is O, S, NH, or NR 6 ;  
         Z 2  is O, S, NH, or NR 6 ; and  
         (i) Y is J—J′—J″ where J is (CR 7 R 7′ )n and n=0-3, J′ is a bond, C═O, CR 7 R 7′ , C═CR 8 R 8′ , R 2 P═O, R 2 P═S, R 2 OP═O, R 2 NHP═O, OP═OR 2 , C═NR 7 , cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo or aryl or substituted aryl, and J″ is (CR 7 R 7′ )n and n=0-3, where Y is not a bond;  
         W is CR 7 R 7′ —CR 7 R 7′ , CR 8 ═CR 8′ , CR 7 R 7′ —C═O ′ , cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, or aryl or substituted aryl;  
         A 1  is CR 7  or N; and  
         A 2  is CR 7  or N; or alternatively  
         (ii) Y is absent;  
         W is CR 7 R 7′ —CR 7 R 7′ , CR 8 ═CR 8′ , CR 7 R 7′ —C═O, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, or aryl or substituted aryl;  
         A 1  is CR 7 R 7′  or NR 7 ; and  
         A 2  is CR 7 R 7′  or NR 7 ; or alternatively  
         (iii) Y is absent; and  
         A 1 , A 2  and W together are —NR 7 —N═N—; and  
         Q 1  is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycloalkyl or substituted heterocycloalkyl, arylalkyl or substituted arylalkyl, alkynyl or substituted alkynyl, aryl or substituted aryl, heterocyclo (e.g., heteroaryl) or substituted heterocyclo (e.g., substituted heteroaryl), halo, CN, R 1 OC═O, R 4 C═O, R 5 R 6 NC═O, HOCR 7 R 7′ , nitro, R 1 OCH 2 , R 1 O, NH 2 , C═OSR 1 , SO 2 R 1  or NR 4 R 5 ;  
         Q 2  is H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycloalkyl or substituted heterocycloalkyl, arylalkyl or substituted arylalkyl, alkynyl or substituted alkynyl, aryl or substituted aryl, heterocyclo (e.g., heteroaryl) or substituted heterocyclo (e.g., substituted heteroaryl), halo, CN, R 1 OC═O, R 4 C═O, R 5 R 6 NC═O, HOCR 7 R 7′ , nitro, R 1 OCH 2 , R 1 O, NH 2 , C═OSR 1 , SO 2 R 1  or NR 4 R 5 ;  
         L is a bond, (CR 7 R 7′ )n, NH, NR 5 , NH (CR 7 R 7′ )n, or NR 5 (CR 7 R 7′ )n, where n=0-3;  
         R 1  and R 1′  are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkyalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl;  
         R 2  is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl;  
         R 3  and R 3′  are each independently H, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, halo, CN, hydroxylamine, hydroxamide, alkoxy or substituted alkoxy, amino, NR 1 R 2 , thiol, alkylthio or substituted alkylthio;  
         R 4  is H, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, R 1 C═O, R 1 NHC═O, SO 2 OR 1 , or SO 2 NR 1 R 1′ ;  
         R 5  is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, R 1 C═O, R 1 NHC═O, SO 2 R 1 , SO 2 OR 1 , or SO 2 NR 1 R 1′ ;  
         R 6  is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, CN, OH, OR 1 , R 1 C═O, R 1 NHC═O, SO 2 R 1 , SO 2 OR 1 , or SO 2 NR 1 R 1′ ;  
         R 7  and R 7′  are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkylalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, halo, CN, OR 1 , nitro, hydroxylamine, hydroxylamide, amino, NHR 4 , NR 2 R 5 , NOR 1 , thiol, alkylthio or substituted alkylthio, R 1 C═O, R 1 OC═O, R 1 C═O—O—, R 1 NHC═O, SO 2 R 1 , SOR 1 , PO 3 R 1 R 1′ , R 1 R 1′ NC═O, C═OSR 1 , SO 2 R 1 , SO 2 OR 1 , or SO 2 NR 1 R 1′ ; and  
         R 8  and R 8′  are each independently H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo, cycloalkylalkyl or substituted cycloalkyalkyl, cycloalkenylalkyl or substituted cycloalkenylalkyl, heterocycloalkyl or substituted heterocycloalkyl, aryl or substituted aryl, arylalkyl or substituted arylalkyl, nitro, halo, CN, OR 1 , amino, NHR 4 , NR 2 R 5 , NOR 1 , alkylthio or substituted alkylthio, C═OSR 1 , R 1 OC═O, R 1 C═O, R 1 NHC═O, R 1 R 1′ NC═O, SO 2 OR 1 , S═OR 1 , SO 2 R 1 , PO 3 R 1 R 1′ , or SO 2 NR 1 R 1′ .  
         wherein said condition or disorder is selected from the group consisting of proliferate diseases, cancers, benign prostate hypertrophia, adenomas and neoplasies of the prostate, benign or malignant tumor cells containing the androgen receptor, heart disease, angiogenic conditions or disorders, hirsutism, acne, hyperpilosity, inflammation, immune modulation, seborrhea, endometriosis, polycystic ovary syndrome, androgenic alopecia, hypogonadism, osteoporosis, suppressing spermatogenisis, libido, cachexia, anorexia, inhibition of muscular atrophy in ambulatory patients, androgen supplementation for age related decreased testosterone levels in men, cancers expressing the estrogen receptor, prostate cancer, breast cancer, endometrial cancer, hot flushes, vaginal dryness, menopause, amennoreahea, dysmennoreahea, contraception, pregnancy termination, cancers containing the progesterone receptor, menopause, cyclesynchrony, meniginoma, fibroids, labor induction, autoimmune disease, Alzheimer's disease, psychotic disorders, drug dependence, non-insulin dependent Diabetes Mellitus, dopamine receptor mediated disorders, congestive heart failure, disregulation of cholesterol homeostasis, and attenuating the metabolism of a pharmaceutical agent.  
       
     
     
         4 . The method of  claim 2 , wherein said compound is selected from the group consisting of; 
 (3a α,4α,7aα)-2-(3-Chloro-4-hydroxyphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-[4-(1H-tetrazol-5-yl)phenyl]-4, 7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1:1), (3aα,4α,7α,7aα)-Hexahydro-2-[3-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-2-oxo-6-benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-3-methyl-2-oxo-6-benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-1-methyl-2-oxo-1H-indol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2-Fluorenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(1H-Benzotriazol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[3-Chloro-4-(4-morpholinyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-1H-inden-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3a α,4α,7α,7aα)-2-(4-Bromo-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Chloro-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(7-hydroxy-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(1H-indol-5-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(1H-indazol-6-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(1,3-Benzodioxol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Amino-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-methyl-4-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(8-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(5-isoquinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,5-Dimethoxy-4-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2,3,5,6-Tetrafluoro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4, 7-methano-2H-isoindol-2-yl)benzonitrile, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trifluorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trichlorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,4-Difluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-1H-indol-6-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,4-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3,4, 5-trichlorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-methyl-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Chloro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,4-Dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromo-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Fluoro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Fluoro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Chloro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Chloro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Chloro-2-methoxy-5-methylphenyl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,5-Dichloro-4-hydroxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-hydroxy-3-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7aα)-2-(4-Amino-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2,2′-(2,3,5,6-Tetramethyl-1,4-phenylene)bis[3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione], (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-methyl-3-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trimethoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,4-Dimethoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione,.(3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3-hydroxy-4-methoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(5-Chloro-2-hydroxy-4-nitrophenyl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-methoxy-3-dibenzofuranyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,3, 4-trifluorophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-2-methyl-1,3-dioxo-1H-isoindol-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromo-2,3,5,6-tetrafluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[2,5-Dichloro-4-(1H-pyrrol-1-yl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[3-[(Diethylamino)methyl]-4-hydroxyphenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(6-Benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-methoxybenzenecarboxylic acid, methyl ester, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-methyl-8-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,3,5, 6-tetramethyl-4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trimethylphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Fluoro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3-methoxy-4-methylphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-N-Ethyl-5-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-methyl-N-phenylbenzenesulfonamide, (3aα,4α,7α,7aα)-6-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2,4-dimethyl-3-pyridinecarbonitrile, (3aα,4α,7α,7aα)-2-(3-Dibenzofuranyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2′-hydroxy[1,1′:3′,1″-terphenyl]-5′-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(1,3-Dihydro-2,2-dioxidobenzo[c]thiophen-5-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,2,3,3-tetrafluoro-2,3-dihydro-1, 4-benzodioxin-6-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Amino-2,3,5,6-tetrafluorophenyl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-N-[2-Chloro-6-fluoro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)phenyl]acetamide, (3aα,4α,7α,7aα)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-(trifluoromethyl)benzonitrile, (3aα,4α,7α,7aα)-2-Fluoro-5-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzonitrile, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[2-Ethoxy-8-methyl-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[1,2-Dihydro-8-methyl-2-oxo-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(9-Ethyl-9H-carbazol-2-yl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[4-(1-piperidinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[4-(4-morpholinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(7-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chlorophenyl)-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(1,2,3,4-tetrahydro-2-oxo-7-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[3-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-methylphenoxy]-2-methylpropanoic acid, ethyl ester, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[4-(4-methyl-1-piperazinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-(Diethylamino)-1-naphthalenyl]-3a,4,7,7a-tetrahydro-4, 7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(8-hydroxy-5-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,5-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1 ,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[4-(1,2,3-thiadiazol-4-yl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-N-[2-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-4-(trifluoromethyl)phenyl]acetamide, (3aα,4α,7α,7aα)-N-[5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-3-(trifluoromethyl)phenyl]acetamide, (3aα,4α,7α,7aα)-2-[3-Amino-5-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[1,2-Dihydro-2-oxo-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-N-[5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-6-(methylthio)-8-quinolinyl]acetamide, (3aα,4α,7α,7aα)-2-[5-Ethoxy-2-(methoxymethyl)-4-(4-morpholinyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[(1R)-1-(1-naphthalenyl)ethyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[(1S)-1-(1-naphthalenyl)ethyl]-3a,4,7,7a tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4-Fluoro-N-[3-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-5-(trifluoromethyl)phenyl]benzenesulfonamide, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[7-(trifluoromethyl)-4-quinolinyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[8-(trifluoromethyl)-4-quinolinyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,4-Dimethyl-5-isoxazolyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-tetrahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4-( 1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenecarbonitrile, (3aα,4α,7α,7aα)-3-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzo[b]thiophene-2-carboxylic acid, methyl ester, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(5-nitro-8-isoquinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1:1), (3aα,4α,7α,7aα)-2-(4-Amino-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-hydroxy-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3-methylphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzonitrile, (3aα,4α,7α,7aα)-N-[4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenyl]acetamide, (3aα,4α,7α,7aα)-N-[4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenyl]methanesulfonamide, (3aα,4α,7α,7aα)-2-(5-Bromo-8-isoquinolinyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(7,8-Dichloro-5-quinolinyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3-methyl-4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-N-[4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenyl]-N′-methylurea, (3aα,4α,7α,7aα)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-methoxy-1-naphthalenecarbonitrile, (3aα,4α,7α,7aα)-2-(6-Bromo-1,2-benzisoxazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(5-Bromo-1,2-benzisoxazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Fluoro-1H-indazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(6-Chloro-1H-indazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(5-nitro-1,2-benzisoxazol-3-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-benzofurancarboxylic acid, methyl ester, (3aα,4α,7α,7aα)-2-(3-Benzofuranyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Chlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2-Fluorenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(1H-Benzotriazol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[3-Chloro-4-(4-morpholinyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-1H-inden-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromo-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Chloro-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(5-Amino-1-naphthalenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(7-hydroxy-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(1H-indol-5-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(1H-indazol-6-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(1,3-Benzodioxol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Amino-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-iodophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(8-quinolinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(1,4-Benzodioxin-6-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(5-isoquinolinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,5-Dimethoxy-4-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2-Amino-4,5-dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,4-Difluorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-1-Acetyl-6-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2,3-dihydro-1H-indole, (3aα,4α,7α,7aα)-(3-Chloro-4-fluorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,4-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-methylphenyl)-3a,4,7 ,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-methyl-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Chloro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,4-Dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromo-3-methylphenyl)-3a,4,7 ,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Fluoro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Fluoro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Chloro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Chloro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Chloro-2-methoxy-5-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,5-Dichloro-4-hydroxyphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-hydroxy-3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Amino-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Amino-2,3,5,6-tetramethylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-methyl-3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3,4,5-trimethoxyphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,4-Dimethoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3-hydroxy-4-methoxyphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-6-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-1,4(2H,3H)-phthalazinedione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-methyl-5-nitro-2-pyridinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-Chloro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-a-phenylbenzeneacetonitrile, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-methoxy-3-dibenzofuranyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,3,4-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-2-methyl-1,3-dioxo-1H-isoindol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[2,5-Dichloro-4-(1H-pyrrol-1-yl)phenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[3-[(Diethylamino)methyl]-4-hydroxyphenyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(6-Benzothiazolyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-methoxybenzoic acid, methyl ester, (3aα,4α,7α,7aα)-5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-methylbenzonitrile, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-methyl-8-quinolinyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,3,5,6-tetramethyl-4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,4,5-trimethylphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Fluoro-3-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(3-methoxy-4-methylphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-N-Ethyl-5-( 1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-methyl-N-phenylbenzenesulfonamide, (3aα,4α,7α,7aα)-2,6-Dibromo-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)benzenesulfonamide, (3aα,4α,8α,8aα)-2-(2,3-Dimethyl-1H-indol-5-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Dibenzofuranyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2′-hydroxy[1,1′:3′,1″-terphenyl]-5′-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(5,6,7,8-tetrahydro-3-hydroxy-2-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(1,3-Dihydro-2,2-dioxidobenzo[c]thiophen-5-yl)hexahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-hydroxy-4,5-dimethylphenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(1H-indazol-5-yl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Amino-2,3,5,6-tetrafluorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromo-3-chlorophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(5-hydroxy-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-N-[2-Chloro-6-fluoro-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)phenyl]acetamide, (3aα,4α,7α,7aα)-4-( 1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-(trifluoromethyl)benzonitrile, (3aα,4α,7α,7aα)-5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)-2-(4-morpholinyl)benzoic acid, methyl ester, (3aα,4α,7α,7aα)-2-Fluoro-5-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-ethano-2H-isoindol-2-yl)benzonitrile, (3aα,4α,7α,7aα)-2-(4-Bromophenyl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(2-naphthalenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[3-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,8α,8aα)-2-(9-Ethyl-9H-carbazol-3-yl)-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,8α,8aα)-2-[1,2-Dihydro-8-methyl-2-oxo-4-(trifluoromethyl)-7-quinolinyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[3,5-Bis(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(2,3-Dihydro-1H-inden-5-yl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-4-(Octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)-1-naphthalenecarbonitrile, (3aα,4α,7α,7aα)-2-(4-Chloro-1-naphthalenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(2-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(5-quinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(6-quinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(5-isoquinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3,5-Dinitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(2,5-Dibromophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(2,4,5-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-[2-Fluoro-5-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(2-Fluoro-5-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(2,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(2-Chloro-4-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-[2-Chloro-5-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3-Fluorophenyl)tetrahydro-3,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3,4-Difluorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3,5-Difluorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3-Chlorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-fluorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3,4-Dichlorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(3,4,5-trichlorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(3-iodophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3-Acetylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-[3-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3,4-Dimethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3,5-Dimethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3-Ethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Bromophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Fluoro-3-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-[4-Fluoro-3-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Chloro-3-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(4-iodophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-[4-(1-methylethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(4-methyl-3-nitrophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-4-(Octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzeneacetonitrile, (3aα,4α,7α,7aα)-2-(4-Ethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-[4-[2-(Acetyloxy)ethyl]phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(4-propylphenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(2,3,4-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3a ,4α,7α,7aα)-2-(4-Bromo-2,6-difluorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(6-Benzothiazolyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(2-methyl-8-quinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Fluoro-3-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(1,3-Dihydro-3-oxo-5-isobenzofuranyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-N-[2-Nitro-4-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)phenyl]acetamide, (3aα,4α,7α,7aα)-2-(2-Ethyl-5-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(2-methyl-5-benzofuranyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(1H-indazol-5-yl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Bromo-3-chlorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-[3-(trifluoromethoxy)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-4-(Octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)-2-(trifluoromethyl)benzonitrile, (3aα,4α,7α,7aα)-Tetrahydro-2-[2-(methylsulfonyl)-4-nitrophenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione; (3aα,4α,7α,7aα)-2-(3,5-Dibromophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(3-iodo-4-methylphenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-iodophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(2-methyl-6-quinolinyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-[2-(methylthio)-5-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Bromo-2,6-diethylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Chloro-3-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-N-Methyl-3-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzamide, (3aα,4α,7α,7aα)-2-(6-Acetyl-1,3-benzodioxol-5-yl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(3,4,5-trifluorophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-Bromo-5-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzoic acid, methyl ester, (3aα,4α,7α,7aα)-2-(3-Chloro-4-nitrophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-[5-[(Difluoromethyl)sulfonyl]-2-methoxyphenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Bromo-1-naphthalenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(3,5-Dichlorophenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-[4-Bromo-3-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Bromo-3-methylphenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(4-Bromo-1-naphthalenyl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-(1-naphthalenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-[2-methyl-3-(trifluoromethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-(2,2-Difluoro-1,3-benzodioxol-5-yl)tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-[4-(4-Chlorophenoxy)-2-(trifluoromethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-2-Fluoro-5-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzonitrile, (3aα,4α,7α,7aα)-2-Chloro-4-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzonitrile, (3aα,4α,7α,7aα)-N-[4-(Octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)-2-(trifluoromethyl)phenyl]acetamide, (3aα,4α,7α,7aα)-2-[4-(1,1-Dimethylethyl)-3-nitrophenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione (3aα,4α,7α,7aα)-Tetrahydro-2-(3-methyl-4-nitrophenyl)-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-Tetrahydro-2-[3-(1-methylethyl)phenyl]-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-N-(1,1-Dimethylethyl)-5-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)-1-naphthalenesulfonamide, (3aα,4α,7α,7aα)-2-[3-(1,1-Dimethylethyl)phenyl]tetrahydro-4,7-ethano-1H-isoindole-1,3,5(2H,4H)-trione, (3aα,4α,7α,7aα)-N-Butyl-3-(octahydro-1,3,5-trioxo-4,7-ethano-2H-isoindol-2-yl)benzenesulfonamide, (3aα,4β,4aα,5aα,6β,6aα)-2-(3,4-Dichlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Bromo-3-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-( 1-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(2-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3,5-Dichlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-[3,5-Bis(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(2,3-Dihydro-1H-inden-5-yl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)-1-naphthalenecarbonitrile, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Bromo-1-naphthalenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Chloro-1-naphthalenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(5-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(6-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β, 6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(5-isoquinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3,5-Dinitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(2,4,5-trifluorophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-[2-Fluoro-5-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5 aα,6β,6aα)-2-(2-Fluoro-5-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(2-Chloro-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-[2-Chloro-5-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Fluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3,4-Difluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Fluoro-4-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3,5-Difluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Chlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Chloro-4-fluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(3,4,5-trichlorophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Chloro-4-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]lisoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(3-iodophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(3-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Acetylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3,4-Dimethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3,5-Dimethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(hydroxymethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Ethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzonitrile, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Bromophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Fluoro-3-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-[4-Fluoro-3-(trifluoromethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Chloro-3-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(4-iodophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(4-nitrophenyl)-4,6- ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(1-methylethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(4-methyl-3-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzeneacetonitrile, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Ethylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(4-propylphenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(2,3,4-trifluorophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-[4-(1,1-Dimethylethyl)-3-nitrphenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Bromo-2,6-difluorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(6-Benzothiazolyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(2-methyl-8-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Fluoro-3-methylphenyl)-4,4a,5 ,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-( 1,3-Dihydro-3-oxo-5-isobenzofuranyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-N-[2-Nitro-4-(octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)phenyl]acetamide, (3aα,4β,4aα,5aα,6β,6aα)-2-(5-Acetyl-2-methyl-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(2-Ethyl-5-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(2-methyl-5-benzofuranyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(2,3-Dihydro-1-oxo-1H-inden-5-yl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(1H-indazol-5-yl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Bromo-3-chlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5 ,5a,6,6a-Hexahydro-2-[3-(trifluoromethoxy)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)-2-(trifluoromethyl)benzonitrile, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[4-methoxy-3-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3,5-Dibromophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(3-iodo-4-methylphenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Chloro-4-iodophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β, 6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(2-methyl-6-quinolinyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(4-Chloro-3-methylphenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[2-[(1-methylethyl)amino]-5-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Chloro-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(3-methyl-4-nitrophenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-[5-[(Difluoromethyl)sulfonyl]-2-methoxyphenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-[3-(1-methylethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-N-(1,1-Dimethylethyl)-5-(octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)-1-naphthalenesulfonamide, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[4-[(trifluoromethyl)thio]phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[2-(2-methoxyphenoxy)-5-(trifluoromethyl)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-N-[4-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)-2-(trifluoromethyl)phenyl]acetamide, (3aα,4β,4aα,5aα,6β,6aα)-2-(3-Acetyl-4-nitrophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-[3-(1,1-Dimethylethyl)phenyl]-4,4a,5,5a,6,6a-hexahydro-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-N-Butyl-3-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzenesulfonamide, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[2-methyl-3-(trifluoromethyl)phenyl]-4,6-A ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-Fluoro-5-(Octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzonitrile, (3aα,4β,4aα,5aα,6β,6aα)-N-Methyl-3-(octahydro-1,3-dioxo-4,6-ethanocycloprop[f]isoindol-2(1H)-yl)benzamide, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,6-ethanocycloprop[f]isoindole-1,3(2H,3aH)-dione, 2-(2-Fluorenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-[3-Chloro-4-(4-morpholinyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, 2-(2,3-Dihydro-1H-inden-5-yl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-1-naphthalenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Chloro-1-naphthalenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(3-iodo-4-methylphenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(4-nitro-1-naphthalenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(1H-indol-5-yl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(5-quinolinyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(1H-indazol-6-yl)-1H-isoindole-1,3(2H)-dione, 2-(1,3-Benzodioxol-5-yl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3-Fluoro-4-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(8-quinolinyl)-1H-isoindole-1,3(2H)-dione, 2-(2,3-Dihydro-1,4-benzodioxin-6-yl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(5-isoquinolinyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,4,5-trifluorophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,4,5-trichlorophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,3,4,6-tetrafluorophenyl)-1H-isoindole-1,3(2H)-dione, 2-(3,4-Difluorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 1-Acetyl-2,3-dihydro-6-(octahydro-1,3-dioxo-2H-isoindol-2-yl)-1H-indole, 2-(3-Chloro-4-fluorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione 2-(3,4-Dichlorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(3,4,5-trichlorophenyl)-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-methoxyphenyl)hexahydro-1-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2-methyl-1-naphthalenyl)-1H-isoindole-1,3(2H)-dione, 2-(4-Chloro-3-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3 ,4-Dimethylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-[4-Bromo-3-(trifiuorometlyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-3-methylphenyl)hexahydro-1H-isoindole-1,3(2H )-dione, 2-(4-Fluoro-3-nitrophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2- [4-Fluoro-3-(trifluoromethyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Chloro-3-nitrophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2- [4-Chloro-3-(trifluoromethyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Chloro-2-methoxy-5-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3-Fluoro-4-methoxyphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-Bromo-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)benzoic acid, methyl ester, Hexahydro-2-(4-methyl-3-nitrophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(3,4,5-trimethoxyphenyl)-1H-isoindole-1,3(2H)-dione, 2-(3,4-Dimethoxyphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-[2-(2-pyridinyl)-1H-benzimidazol-5-yl]-1H-isoindole-1,3(2H)-dione, 2-(9-Ethyl-9H-carbazol-3-yl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2-methoxy-3-dibenzofuranyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,3,4-trifluorophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-methyl-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-[6-(methylthio)-5-nitro-8-quinolinyl]-1H-isoindole-1,3(2H)-dione, 2-[2,5-Dichloro-4-(1H-pyrrol-1-yl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(6-methyl-5-quinolinyl)-1H-isoindole-1,3(2H)-dione, N-(l,1-Dimethylethyl)-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)-1-naphthalenesulfonamide, Hexahydro-2-[4-(methoxymethyl)-2-oxo-2H-1-benzopyran-7-yl]-1H-isoindole-1,3(2H)-dione, 2-(6-Benzothiazolyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-Methoxy-4-(octahydro-1,3-dioxo-2H-isoindol-2-yl)benzoic acid, methyl ester, 2-Methyl-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)benzonitrile, Hexahydro-2-(2-oxo-2H-1-benzopyran-6-yl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2-methyl-8-quinolinyl)-1H-isoindole-1,3(2H)-dione, 2- [3,5-Bis(trifluoromethyl)phenyl]hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,4,5-trimethylphenyl)-1H-isoindole-1,3(2H)-dione, 2-(4-Fluoro-3-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(3-methoxy-4-methylphenyl)-1H-isoindole-1,3(2H)-dione, N-Ethyl-2-methyl-5-(octahydro-1 ,3-dioxo-2H-isoindol-2-yl)-N-phenylbenzenesulfonamide, 2-(2,3-Dimethyl-1H-indol-5-yl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3-Dibenzofuranyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-nitrophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(1,3-Dihydro-2,2-dioxidobenzo[c]thiophen-5-yl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(6-nitro-2-naphthalenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(1H-indazol-5-yl)-1H-isoindole-1,3(2H)-dione, 2-(4-Amino-2,3,5,6-tetrafluorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-3-chlorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-1H-isoindole-1,3(2H)-dione, 4-(Octahydro-1,3-dioxo-2H-isoindol-2-yl)-2-(trifluoromethyl)benzonitrile, Hexahydro-2-(9-oxo-9H-fluoren-1-yl)-1H-isoindole-1,3(2H)-dione, 2-Fluoro-5-(octahydro-1,3-dioxo-2H-isoindol-2-yl)benzonitrile, Hexahydro-2-(9-oxo-9H-fluoren-2-yl)-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-iodophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-2,3,5,6-tetrafluorophenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,3,5,6-tetramethyl-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1H-isoindole-1,3(2H)-dione, 2-(3-Bromo-4-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, 2-(4-Bromo-2-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(1-naphthalenyl)-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-2-methylphenyl)hexahydro-1H-isoindole-1,3(2H)-dione, (3aα,4α, 7α,7aα)-Hexahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2-Amino-4,5-dichlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(8-hydroxy-5-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenecarbonitrile, (3aα,4α,7α,7aα)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromo-1-naphthalenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(2-Fluorenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(2-methyl-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,5-Dichlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Chloro-4-fluorophenyl)hexahydro-4,7-methano-1,3(2H)-dione, (3 aα,4α,7α,7 aα)-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Bromo-3-(trifluoromethyl)phenyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromo-3-methylphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(4-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(1-oxido-4-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(6-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(1-oxido-6-quinolinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(5-nitro-8-isoquinoliny)-4,7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1:1), (3aα,4α,7α,7aα)-Hexahydro-2-[4-(methylsulfonyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-[4-(methylthio)phenyll-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzenesulfonamide, (3aα,4α,7α,7aα)-Hexahydro-2-[4-(methylsulfinyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Fluoro-1-naphthalenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1-naphthalenecarboxylic acid, methyl ester, (3aα,4α,7α,7aα)-2-(1,1-Dioxido-2H-naphth[1,8-cd]isothiazol-5-yl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Hexahydro-2-(6-hydroxy-3-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(1,2-Benzisothiazol-3-yl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3-Benzofuranyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-2-benzofurancarboxylic acid, methyl ester, (3aα,4α,7α,7aα)-Hexahydro-2-[4-(4-isothiazolyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,4aβ,5aβ,6α,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4α,4aβ,5aβ,6α,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4α,4aβ,5aβ,6α,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4α,4aβ,5aβ,6α,6aα)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)-4,4a,5,5a,6,6a-hexahydro-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(3,5-Dichlorophenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-(trifluoromethyl)phenyl]-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,4aα,5aα,6β,6aα)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)-4,4a,5,5a,6,6a-hexahydro-4,6-methanocycloprop[f]isoindole-1,3(2H,3aH)-dione, (3aα,4β,7β,7aα)-3a,4,7,7a-tetrahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-Hexahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-2-(3,5-Dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-3a,4,7,7a-Tetrahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-3a,4,7,7a-Tetrahydro-2-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-3a,4,7,7a-Tetrahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-1lexahydro-2-(2-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-2-(3,5-Dichlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-Hexahydro-2-(4-nitro-1 -naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5α,7α,7aα)-Hexahydro-2-(2-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5α,7α,7aα)-Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5α,7α,7aα)-Hexahydro-2-(1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5α,7α,7aα)-2-(3,4-Dichlorophenyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5α,7α,7aα)-2-(3,5-Dichlorophenyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5α,7α,7aα)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5β,7α,7aα)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, trifluoroacetate (1:1), (3aα,4α,5β,7α,7aα)-Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5α,7α,7aα)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5α,7α,7aα)-Hexahydro-2-(4-nitro-1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5β,7α,7aα)-Hexahydro-2-(4-nitro-1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5β,7α,7aα)-Hexahydro-2-[4-nitro-3-(trifluoromethyl)phenyl]-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,8β,8aα)-4,5,6,7,8,8a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα,4β,8β,8aα)-4,5,6,7,8,8a-Hexahydro-2-(4-nitrophenyl)-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα,4β,8β,8aα)-4,5,6,7,8,8a-Hexahydro-2-(2-naphthalenyl)-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα,4β,8β,8aα)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-4,5,6,7 ,8,8a-hexahydro-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα,4β,8β,8aα)-2-(3,4-Dichlorophenyl)-4,5,6,7,8,8a-hexahydro-4,8-ethanocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα,4β,8β,8aα)-4,5,6,7,8,8a-Hexahydro-2-(4-nitro-1-naphthalenyl)-4,8-ethanocyclohepta[c]pyrrole-1,3 (2H,3aH)-dione, (3aα,4β,8β,8aα)-2-(3,4-Dichlorophenyl)-4,5,6,7,8,8a-hexahydro-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα,4β,8β,8aα)-2-(3,5-Dichlorophenyl)-4,5,6,7,8,8a-hexahydro-4,8-ethenocyclohepta[c]pyrrole-1,3(2H,3aH)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-(3-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-2-[4-(methylthio)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-2-(5-chloro-2-methoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-(3 -methoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-(1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-2-(2,3-dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-2-(3,4-dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromophenyl)4,5,6,7,8,8-hexachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-[2-methyl-5-(1-methylethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-N-(2-cyanophenyl)-1,4,5,6,7,7-hexachloro-5-norbornene-2,3-dicarboximide, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-2-(3-chloro-4-methylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-2-(2,3-dichlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-3a,4,7,7a-tetrahydro-2-[3-(methylthio)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-4,5,6,7,8,8-Hexachloro-2-(4-fluoro-3-nitrophenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(6-methyl-2-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(4-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(3-pyridinyl)-4,7-methano-1H-isoindole-1,3 (2H)-dione, 3 a,4,7,7a-Tetrahydro-2-(2-pyridinyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(3-methyl-2-pyridinyl)-4,7-methano-1H-isoindole-1,3 (2H)-dione, N-(4,6-Dimethyl-2-pyrmidinyl)-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzenesulfonamide, 3a,4,7,7a-Tetrahydro-2-[4-(2-hydroxyethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(2-mercaptophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, 2-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, methyl ester, 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, 3-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, methyl ester, 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzenesulfonamide, N-(4,5-Dihydro-5-methyl-3-isoxazolyl)-4-(1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzenesulfonamide, 3a,4,7,7a-Tetrahydro-2-(2-hydroxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[4-(phenylmethoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[2-(phenylmethoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[3-(phenylmethoxy)phenyll]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[4-[(4-nitrophenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[2-[(4-nitrophenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[3-[(4-nitrophenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[4-[(4-methylphenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[3-[(4-methylphenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3 (2H)-dione, 3a,4,7 ,7a-Tetrahydro-2-[2- [(4-methylphenyl)methoxy]phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[4-[(4-Butylphenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[2-[(4-Butylphenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[3-[(4-Butylphenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[4-[(2-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[4-[(4-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[2-[(4-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[2-[(2-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[3-[(2-Chlorophenyl)methoxylphenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[3-[(4-Chlorophenyl)methoxy]phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[(Benzoyloxy)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-[3-(3,4-Dimethylbenzoyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(3,4-Dimethylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, ethyl ester, 5-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-1,3-benzenedioic acid, 4-[2-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)phenoxy]benzonitrile, 2-(5-Chloro-2-methoxyphenyl)-3a,4,7,7atetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(2-Acetylphenyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[4-(5-oxazolyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[4-Bromo-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-5-methyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2′-[4-Bromo-3-(trifluoromethyl)phenyl]-3′a,4′,7′,7′a-tetrahydrospiro [cyclopropane-1,8′-[4,7]methano[1H]isoindole]-1′,3′(2′H)-dione, (3aα,4β,4aα6aα,7β,7aα)-2-(4-Bromo-1 -naphthalenyl)-3a,4,4a,6a,7,7a-hexahydro-4,7-etheno-1H-cyclobut[f]isoindole-1,3(2H)-dione, (3aα,4β,4aα,6aα,7β,7aα)-2-(4-Bromo-3-methylphenyl)-3a,4,4a,6a,7,7a-hexahydro-4,7-etheno-1H-cyclobut[f]isoindole-1,3(2H)-dione, (3aα,4β,4aα,6aα,7β,7aα)-2-(1,2-Dihydro-4-methyl-2-oxo-7-quinolinyl)-3a,4,4a,6a,7,7a-hexahydro-4,7-etheno-1H-cyclobut[f]isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-2-[3,5-Bis(trifluoromethyl)phenyl]hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-2-(4-Bromo-3-methylphenyl)hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-Hexahydro-8-(1-methylethylidene)-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-2-(4-Bromo-1-naphthalenyl)hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-Hexahydro-8,8-dihydroxy-2-(4-nitro-1-naphthalenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-2-[3,5-Bis(trifluoromethyl)phenyl]hexahydro-8,8-dihydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4β,7β,7aα)-2-(4-Bromo-3-methylphenyl)hexahydro-8,8-dihydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromo-3-methylphenyl)hexahydro-8,8-dihydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(4-Bromo-3-methylphenyl)hexahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-[4-nitro-3-(trifluoromethyl)phenyl] 5 -phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-(3,5-Dichlorophenyl)-3a,4,7,7a-tetrahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-Tetrahydro-2-[[3-(trifluoromethyl)phenyl]amino]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-2-[(3-Chlorophenyl)amino]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,5α,7α,7aα)-Hexahydro-5-mercapto-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, (3aα,4α,7α,7aα)-3a,4,7,7a-Tetrahydro-2-(4-nitro-1-naphthalenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, (3a′α,4′α,7′α,7a′α)-2′-(1,2-Dihydro-4-methyl-2-oxo-7-qiunolinyl)-3a′,4′,7′,7a′-tetrahydrospiro[cyclopropane-1,8′-[4,7]methano[1H]isoindole]-1′,3′(2′H)-dione, (3aα,4α,5α,7α,7aα)-Hexahydro-5-4-nitropheny)-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, Hexahydro-2-(2-mercaptophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 4-(Octahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)benzoic acid, ethyl ester, 2-[4-(Diethylamino)phenyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,9,9a-Tetrahydro-2-phenyl-4,9[1′,2′]-benzeno-1H-benz[f]isoindole-1,3(2H)-dione, 5-(Acetyloxy)hexahydro-2-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, 5-(Acetyloxy)-2-(4-chlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 5-(Acetyloxy)hexahydro-2-(2-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 5-(Acetyloxy)-2-(3-chlorophenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, Octahydro-2-(4-methoxyphenyl)-1,3-dioxo-4,7-methano-1H-isoindole-5-carboxylic acid, methyl ester, 2-(2,4-Dichlorophenyl)octahydro-1,3-dioxo-4,7-methano-1H-isoindole-5-carboxylic acid, methyl ester, Octahydro-2-(4-nitrophenyl)-1,3-dioxo-4,7-methano-1H-isoindole-5-carboxylic acid, methyl ester, Hexahydro-5-hydroxy-2-(4-methoxyphenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)hexahydro-5-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, Hexahydro-5-hydroxy-2-(4-nitrophenyl)-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(4-Chlorophenyl)hexahydro-5-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(2,4-Dichlorophenyl)hexahydro-5-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione, Hexahydro-5-hydroxy-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 5-(Acetyloxy)hexahydro-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-Hydroxy-5-(octahydro-1,3-dioxo-5-phenyl-1H-isoindol-2-yl)benzoic acid, Hexahydro-2-(4-hydroxyphenyl)-5-phenyl-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)hexahydro-5-phenyl-1H-isoindole-1,3(2H)-dione, Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione, 2-(3-Dibenzofuranyl)-3a,4,7,7a-tetrahydro-4,7-diphenyl-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(4-methoxyphenyl)-5-methyl-1H-isoindole-1,3(2H)-dione, 5-(2,4-Dimethylphenyl)-1,6a-dihydro-1-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-d]-1,2,3-triazole-4,6(3aH,5H)-dione, Tetrahydro-2-phenyl-1H-isoindole-1,3,5(2H,4H)-trione, 5,6-Dibromo-2-(4-ethoxyphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5,6-dimethyl-2-[4-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5,6-dimethyl-2-(2-propoxyphenyl)-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-2-methylphenyl)-3a,4,7,7a-tetrahydro-8-(1-methylethylidene)-4,7-methano-1H-isoindole-1,3(2H)-dione, 3′a,4′,7′,7′a-Tetrahydro-2′-(2,4,6-trimethylphenyl)spiro[cyclopropane-1,8′-[4,7]methano[1H]isoindole]-1′,3′(2′H)-dione, 3a,4,7,7a-Tetrahydro-4-methyl-2-(3-methylphenyl)-1H-isoindole-1,3(2H)-dione, Hexahydro-2-[4-(2-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)phenyl]-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5-methyl-2-[4-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5-methyl-2-[4-(trifluoromethoxy)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(3-Chloro-4-fluorophenyl)hexahydro-5-methyl-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-5-methyl-2-[3-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione, 4-[1,3,3a,4,7,7a-Hexahydro-8-(1-methylethylidene)-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]benzonitrile, 3a,4,7,7a-Tetrahydro-2-(4-hydroxyphenyl)-1H-isoindole-1,3(2H)-dione, 2-Methyl-2-propenoic acid, 4-(1,3,3a,4,7,7a-hexahydro-5-methyl-1,3-dioxo-2H-isoindol-2-yl)phenyl ester, 2-(4-Chlorophenyl)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione, 4-(1,3 ,3a,4,7,7a-Hexahydro-1,3-dioxo-2H-isoindol-2-yl)benzenesulfonamide, 3a,4,7,7a-Tetrahydro-2-phenyl-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-(2-mercaptophenyl)-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-Tetrahydro-2-[3-(methylthio)phenyl]-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione, 4,4a,5,5a,6,6a-Hexahydro-2-[3-(trifluoromethyl)phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione, 3′a,4′,7′,7′a-Tetrahydro-2′-(4-nitrophenyl)spiro[cyclopropane-1,8′-[4,7]methano[1H]isoindole]-1′,3′(2′H)-dione, 2-Hydroxy-5-(octahydro-1,3-dioxo-5-phenyl-4,7-methano-1H-isoindol-2-yl)benzoic acid, 4-(Octahydro-1,3-dioxo-5-phenyl-4,7-methano-1H-isoindol-2-yl)benzenesulfonamide, Hexahydro-2-(4-hydroxyphenyl)-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, 2-(4-Ethoxyphenyl)hexahydro-5-phenyl-4,7-methano-1H-isoindole-1,3(2H)-dione, Hexahydro-5-phenyl-2-[3-(trifluoromethyl)phenyl]-4,7-methano-1H-isoindole-1,3(2H)-dione and (3aα,4α,7α,7aα)-2-[4-nitro-3-(trifluoromethyl)phenyl]-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione.