US2004092436A1PendingUtilityA1

Immunosuppressive imidazole derivatives and their combination preparations with tacrolimus of cyclosporins

Assignee: FUJISAWA PHARMACEUTICAL COPriority: Apr 6, 1998Filed: Nov 7, 2003Published: May 13, 2004

Est. expiryApr 6, 2018(expired)· nominal 20-yr term from priority

Inventors:Fumihiko Sakai Harumi Yamazaki Noboru Chida Osamu Nakayama Yoshihiro Yokota

A61K 31/00A61K 31/4178A61P 37/06A61P 43/00A61K 31/4439

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Claims

Abstract

Present invention is relating to a new use of a compound possessing an inhibitory activity on the production of nitric oxide, for increasing an effect caused by IL-2 inhibitor.

Claims

exact text as granted — not AI-modified

What is claimed is:  
     
         1 . A method for increasing graft survival time in a transplantation subject having a graft comprising: 
 administering to said subject    compound (a) possessing an inhibitory activity on the production of nitric oxide and compound (b) that is a cyclosporin or a rapamycin,    in an amount and for a time and under conditions effective to increase graft survival time.    
     
     
         2 . The method of  claim 1  comprising administering a cyclosporin.  
     
     
         3 . The method of  claim 1  comprising administering a rapamycin.

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