Peritoneal dialysates

Abstract

In peritoneal dialysis, a therapy for end stage renal disease patients, glucose has been used mainly as an osmotic agent in the dialysate. However due to the oxidation and decomposition of glucose, protein cross linking reaction progress to cause peritoneum sclerosis, resulting in cease of this therapy The present invention relates to the dialysate comprising protein cross linking suppressor(s) and/or protein cross linkage splitter(s) for the solution of the problem. Effective suppressors or splitters may be reductants, anti-oxidants, mercapto compounds, sulfide, hydrosulfide, salt of reductive sulfur oxyacid, thiourea and its derivatives, hydroxyl and/or carboxyl residue(s) containing cyclic compounds flavonoids, nitrogen containing heterocyclic compounds, hydrazyl compounds and uronic acid containing mucopoly-saccharides and the like. The dialysate is prepared by sterilizing the dialysate under high temperature and pressure separately from the suppressors and by adding the suppressors, that is sterilized separately, into the dialysate. By use of the dialysate in the present invention, peritoneal dialysis can keep on without suffering from problem,

1 ) A dialysate of peritoneal dialysis comprising aqueous solution of electrolytes and sugar osmotic agents and protein cross linking suppresser(s) and/or protein cross linkage splitter(s).  
     
     
         2 ) The dialysate of peritoneal dialysis according to  claim 1 , wherein the protein cross linking suppresser(s) is reductant(s) or antioxidant(s).  
     
     
         3 ) The dialysate of peritoneal dialysis according to  claim 2 , wherein reductant(s) or antioxidant(s) is reductant(s) of which redox potential is lower than that of saline solution.  
     
     
         4 ) The dialysate of peritoneal dialysis according to  claim 2 , wherein the protein cross linking suppresser(s) is mercapto compounds, sulfide, hydrosulfide, salts of reductive sulfur oxy-acid, thiourea, or its derivatives, cyclic compounds having hydroxyl and/or carboxyl residues, flavonoids, nitrogen containing cyclic complexes, hydrazyl compounds, or uronic acid containing muco-polysaccharaids.  
     
     
         5 ) The dialysate of peritoneal dialysis according to,  claim 4 , wherein the mercapto compound(s) is N-acetyl cystein, 2-mercaptoethanol, dithioerythrytol, glutathione, or S-acetylmercapto succinic acid anhydride.  
     
     
         6 ) The dialysate of peritoneal dialysis according to  claim 4 , wherein salt of reductive sulfur oxy-acid is sodium, potassium or other physiologically safe salt of sulfite, bisulfite, thiosulfate, metabisulfite, or dithionite.  
     
     
         7 ) The dialysate of peritoneal dialysis according to  claim 4 , wherein cyclic compounds having hydroxyl and/or carboxyl residues is acetyl salicylic acid, ascorbic acid or its physiologically safe salts.  
     
     
         8 ) The dialysate of peritoneal dialysis according to  claim 4 , wherein Flavonoids is quercetin, catechin, epicatechin, or more than two hydroxyl residue containing cyclic complexes.  
     
     
         9 ) The dialysate of peritoneal dialysis according to  claim 4 , wherein nitrogen containing cyclic complexes is compounds having thiazole, thiazoline, thiazolidine, triazole, tetrazole, indole, imidazole, pyridine, or pyrimidine rings.  
     
     
         10 ) The dialysate of peritoneal dialysis according to  claim 9 , wherein compounds having thiazole thiazoline, thiazolidine, triazole, rings is N-(2-thiazolyl) sulfanilamide, thiazol bromide, 2mexcaptothiazoline, 2-oxo-thiazolidine-4-carboxylic acid or 4(1,2,3,4-thiatriazo -5-lylamino)phenol hydrate.  
     
     
         11 ) The dialysate of peritoneal dialysis according to  claim 9 , wherein nitrogen containing cyclic complexes having indole ring is N-acetyl tryptophan.  
     
     
         12 ) The dialysate of peritoneal dialysis according to  claim 9 , wherein hydrazyl compounds is amino guanidine.  
     
     
         13 ) The dialysate of peritoneal dialysis according to  claim 4 , wherein uronic acid containing muco-polysaccharaids is heparin.  
     
     
         14 ) The dialysate of peritoneal dialysis, according to  claims 1  to  13 , wherein oncotic agent is contained as osmotic agent.  
     
     
         15 ) A preparation method of a dialysate of peritoneal dialysis, which comprises sterilizing the dialysate under hyper temperature and pressure, and thereafter mixing the dialysate with protein cross linking suppressor(s) as described in  claims 1  to  13 , which is sterilized separately.  
     
     
         16 ) A preparation method of a dialysate of peritoneal dialysis which comprises sterilizing sugar osmotic agent and protein cross linking suppressor(s) which is described in  claims 1  to  13 , under hyper temperature and pressure, and thereafter mixing with electrolytes which is sterilized separately.