US2004109883A1PendingUtilityA1

Pediculicidal and ovacidal treatment compositions and methods for killing head lice and their eggs

53
Priority: Apr 25, 2001Filed: Dec 2, 2003Published: Jun 10, 2004
Est. expiryApr 25, 2021(expired)· nominal 20-yr term from priority
Inventors:Herwig JanssenKie HoGlenn NystrandDexter WilliamsC. Lamb
A01N 51/00A61P 33/14A01N 25/02A01N 43/22A61K 31/351
53
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Claims

Abstract

The present invention relates to compositions and methods for administering compositions in solutions for killing adult lice and the ova comprising water, PVM/MA Decadiene crosspolymers, propylene glycol, a mixture of cetyl and stearyl alcohols, Ceteareth-20; stearalkonium chloride; benzyl alcohol; hexylene glycol; pentylene glycol, isopropyl alcohol; a mixture of spinosyn A and spinosyn D in a weight ratio of 80:20, BHT; and sodium hydroxide.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A composition comprising: 
 an effective amount of one or more agents having pediculicidal and ovacidal properties for adult lice and nits of a specie of order Anoplura in solution;    wherein the agents comprise a chemical structure of:                          
     
     
         2 . The composition of  claim 1  further comprising one or more stabilizers.  
     
     
         3 . The composition of  claim 1 , wherein the agents consist of one or more of the following: spinosad, spinosyn A, spinosyn D, any component produced by the  Saccharopolyspora spinosa  species and a combination thereof.  
     
     
         4 . The composition of  claim 1  wherein R comprises H.  
     
     
         5 . The composition of  claim 1  wherein R comprises CH 3 .  
     
     
         6 . The composition of  claim 1  wherein R comprises a mixture of H and CH 3 .  
     
     
         7 . The composition of  claim 1  wherein R comprises a mixture of H: CH 3  wherein the relative structures are in a weight ratio of approximately 85:15.  
     
     
         8 . The composition of claim I wherein the agents comprise greater than about 0 to about 10 percent of the composition.  
     
     
         9 . The composition of  claim 1  wherein the agents comprise between about 0.5 to about 5 percent of the composition.  
     
     
         10 . The composition of  claim 2 , wherein the stabilizers comprise one or more of the group consisting of PVM/MA Decadiene crosspolymers, acrylates/aminoacrylates C10-30 Alkyl PEG-20 Itaconate copolymer, long chain acyl derivatives, alkanolamides, esters of long chain of fatty acids, alkyl dimethylamine oxides, methylcellulose, hydroxybutyl methylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, hydroxethyl cellulose, distearyl phthalic amide, di(hydrogenated) tallow phthalic amide, primary amines with a fatty alkyl moiety of at least 16 carbons, polyacrylic acids, polysaccharide gums, colloidal clays and colloidal silica.  
     
     
         11 . The composition of  claim 2 , wherein the stabilizers comprise PVM/MA Decadiene crosspolymers.  
     
     
         12 . The composition of  claim 2  wherein the stabilizers comprise about 0.5 to about 1.5 percent of the composition.  
     
     
         13 . The composition of  claim 2  wherein the stabilizers have a particle size of less than 75μ.  
     
     
         14 . The composition of  claim 1 , wherein the solution further comprises a solvent consisting of one or more of the following: benzyl alcohol, pentylene glycol, isopropyl alcohol, hexylene glycol, butylene glycol, and dipropylene glycol.  
     
     
         15 . The composition of  claim 1  further comprising: 
 one or more stabilizers;  
 one or more moisturizers;  
 one or more emulsion stabilizers;  
 one or more emulsifying agents;  
 one or more conditioning agents;  
 one or more antioxidants; and  
 one or more pH adjuster.  
 
     
     
         16 . The composition of  claim 15  wherein the moisturizer comprises propylene glycol.  
     
     
         17 . The composition of  claim 15  wherein the emulsion stabilizer comprises a mixture of cetyl and stearyl alcohols.  
     
     
         18 . The composition of  claim 15  wherein the emulsifying agent comprises Ceteareth-20.  
     
     
         19 . The composition of  claim 15  wherein the conditioning agent comprises stearalkonium chloride.  
     
     
         20 . The composition of  claim 15  wherein the antioxidant comprises BHT.  
     
     
         21 . The composition of  claim 15  wherein the pH adjuster comprises sodium hydroxide.  
     
     
         22 . The composition of  claim 15  further comprising one or more viscosity increasing agents.  
     
     
         23 . The composition of  claim 22  wherein the viscosity increasing agent comprises a mixture of cetyl and stearyl alcohols.  
     
     
         24 . A composition comprising: 
 an effective amount of one or more agents having pediculicidal and ovacidal properties for adult lice and nits of a specie of order Anoplura in solution;    wherein the agents comprise a chemical structure of:                           and    one or more stabilizers.    
     
     
         25 . A composition comprising: 
 About 44% water;    About 1.1% PVM/MA Decadiene crosspolymers;    About 3% propylene glycol;    About 3% cetearyl alcohol;    About 0.9% ceteareth-20;    About 4.17% stearalkonium chloride;    About 10% benzyl alcohol;    About 6% hexylene glycol;    About 4% pentylene glycol;    About 20% isopropyl alcohol;    About 2.19% mixture of spinosyn A & D in an approximate 85:15 weight ratio;    About 0.1% BHT; and    About 1.29% sodium hydroxide (10% solution).    
     
     
         26 . A composition comprising: 
 Water;    A PVM/MA Decadiene crosspolymers;    Propylene glycol;    A mixture of cetyl and stearyl alcohols;    Ceteareth-20;    Stearalkonium chloride;    Benzyl alcohol;    Pentylene glycol;    Isopropyl alcohol;    A mixture of spinosyn A and spinosyn D in a weight ratio of approximately 85:15;    BHT; and    Sodium hydroxide.    
     
     
         27 . A method of controlling adults and ova of the species of order Anoplura by topically applying to one or more of skin and hair a composition comprising: 
 an effective amount of one or more agents having pediculicidal and ovacidal properties in solution;    wherein the agents comprise a chemical structure of:                          
     
     
         28 . The method of  claim 27  wherein the composition further comprises one or more stabilizers.  
     
     
         29 . The method of  claim 27 , wherein the agents consist of one or more of the following: 
 spinosad, spinosyn, spinosyn A, spinosyn D, any component produced by the  Saccharopolyspora spinosa  species and a combination thereof.    
     
     
         30 . The method of  claim 27 , wherein R comprises H.  
     
     
         31 . The method of  claim 27 , wherein R comprises CH 3 .  
     
     
         32 . The method of  claim 27 , wherein R comprises a mixture of H:CH 3 .  
     
     
         33 . The method of  claim 27 , wherein R comprises a mixture of H:CH 3  wherein the relative structures are in a weight ratio of approximately 85:15.  
     
     
         34 . The method of  claim 27 , wherein the agents comprise greater than about 0 to about 10 percent of the composition.  
     
     
         35 . The method of  claim 27  wherein the agents comprise between about 0.5 to about 5 percent of the composition.  
     
     
         36 . The method of  claim 28 , wherein the stabilizers comprise one or more of the group consisting of PVM/MA Decadiene crosspolymers, acrylates/aminoacrylates C10-30 Alkyl PEG-20 Itaconate copolymer, long chain acyl derivatives, alkanolamides, esters of long chain of fatty acids, alkyl dimethylamine oxides, methylcellulose, hydroxybutyl methylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, hydroxyethyl cellulose, distearyl phthalic amide, di(hydrogenated) tallow phthalic amide, primary amines with a fatty alkyl moiety of at least 16 carbons, polyacrylic acids, polysaccharide gums, colloidal clays and colloidal silica.  
     
     
         37 . The method of  claim 28 , wherein the stabilizer comprise PVM/MA decadiene crosspolymers.  
     
     
         38 . The method of  claim 28  wherein the stabilizers comprises about 0.5 to about 1.5 percent of the composition.  
     
     
         39 . The method of  claim 28  wherein the stabilizers have a particle size of <75μ.  
     
     
         40 . The method of  claim 27 , wherein the solution further comprises a solvent consisting of one or more of the following: benzyl alcohol, pentylene glycol, isopropyl alcohol, hexylene glycol, butylene glycol, and dipropylene glycol.  
     
     
         41 . The method of  claim 27  further comprising: 
 one or more stabilizers;  
 one or more moisturizers;  
 one or more emulsion stabilizers;  
 one or more emulsifying agents;  
 one or more conditioning agents;  
 one or more antioxidants; and  
 one or more pH adjuster.  
 
     
     
         42 . The method of  claim 41  wherein the moisturizer comprises propylene glycol.  
     
     
         43 . The method of  claim 41  wherein the emulsion stabilizer comprises a mixture of cetyl and stearyl alcohols.  
     
     
         44 . The method of  claim 41  wherein the emulsifying agent comprises Ceteareth-20.  
     
     
         45 . The method of  claim 41  wherein the conditioning agent comprises stearalkonium chloride.  
     
     
         46 . The method of  claim 41  wherein the antioxidant comprises BHT.  
     
     
         47 . The method of  claim 41  wherein the pH adjuster comprises sodium hydroxide.  
     
     
         48 . The method of  claim 41  further comprising one or more viscosity increasing agents.  
     
     
         49 . The method of  claim 48  wherein the viscosity increasing agent comprises a mixture of cetyl and stearyl alcohols.  
     
     
         50 . A method of controlling adults and ova of the species of order Anoplura by topically applying to one or more of skin and hair a composition comprising: 
 an effective amount of one or more agents having pediculicidal and ovacidal properties in solution;    wherein the agents comprise a chemical structure of:                           and    one or more stabilizers.    
     
     
         51 . A method of controlling adults and ova of the species of order Anoplura by topically applying to one or more of skin and hair a composition comprising: 
 about 44% water;    about 1.1% PVM/MA decadiene crosspolymer;    About 3% propylene glycol;    About 3% cetearyl alcohol;    About 0.9% ceteareth-20;    About 4.17% stearalkonium chloride;    About 10% benzyl alcohol;    About 6% hexylene glycol;    About 4% pentylene glycol;    About 20% isopropyl alcohol;    About 2.19% mixture of spinosyn A and spinosyn D in an approximate 85:15 weight ratio;    About 0.1% BHT; and    1.29% sodium hydroxide (10% solution).    
     
     
         52 . A method for solubilizing agents having pediculicidal and ovacidal properties comprising: 
 Combining one or more solvents and an effective amount of one or more agents having pediculicidal and ovacidal properties;    wherein the agents comprise a chemical structure of:                          
     
     
         53 . The method of  claim 52  further comprising adding one or more stabilizers.  
     
     
         54 . The method of  claim 52 , wherein the agents consist of one or more of the following: spinosad, spinosyn, spinosyn A, spinosyn D, any component produced by the  Saccharopolyspora spinosa  species and a combination thereof.  
     
     
         55 . The method of  claim 52 , wherein R comprises H.  
     
     
         56 . The method of  claim 52 , wherein R comprises CH 3 .  
     
     
         57 . The method of  claim 52 , wherein R comprises a mixture of H:CH 3 .  
     
     
         58 . The method of  claim 52 , wherein R comprises a mixture of H:CH 3  wherein the relative structures are in a weight ratio of approximately 85:15.  
     
     
         59 . The method of  claim 52 , wherein the agents comprise greater than about 0 to about 10 percent of the composition.  
     
     
         60 . The method of  claim 52  wherein the agents comprise between about 0.5 to about 5 percent of the composition.  
     
     
         61 . The method of  claim 53 , wherein the stabilizers comprise one or more of the group consisting of PVM/MA Decadiene crosspolymers, acrylates/aminoacrylates C10-30 Alkyl PEG-20 Itaconate copolymer, long chain acyl derivatives, alkanolamides, esters of long chain of fatty acids, alkyl dimethylamine oxides, methylcellulose, hydroxybutyl methylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, hydroxyethyl cellulose, distearyl phthalic amide, di(hydrogenated) tallow phthalic amide, primary amines with a fatty alkyl moiety of at least 16 carbons, polyacrylic acids, polysaccharide gums, colloidal clays and colloidal silica.  
     
     
         62 . The method of  claim 53 , wherein the stabilizer comprise PVM/MA decadiene crosspolymers.  
     
     
         63 . The method of  claim 53  wherein the stabilizers comprises about 0.5 to about 1.5 percent of the composition.  
     
     
         64 . The method of  claim 53  wherein the stabilizers have a particle size of <75μ.  
     
     
         65 . The method of  claim 52  further comprising adding a solvent consisting of one or more of the following: benzyl alcohol, pentylene glycol, isopropyl alcohol, hexylene glycol, butylene glycol, and dipropylene glycol.  
     
     
         66 . The method of  claim 52  further comprising adding one or more stabilizers; one or more moisturizers; one or more emulsion stabilizers; one or more emulsifying agents; one or more conditioning agents; one or more antioxidants; and one or more pH adjuster.  
     
     
         67 . The method of  claim 66  wherein the moisturizer comprises propylene glycol.  
     
     
         68 . The method of  claim 66  wherein the emulsion stabilizer comprises a mixture of cetyl and stearyl alcohols.  
     
     
         69 . The method of  claim 66  wherein the emulsifying agent comprises Ceteareth-20.  
     
     
         70 . The method of  claim 66  wherein the conditioning agent comprises stearalkonium chloride.  
     
     
         71 . The method of  claim 66  wherein the antioxidant comprises BHT.  
     
     
         72 . The method of  claim 66  wherein the pH adjuster comprises sodium hydroxide.  
     
     
         73 . The method of  claim 66  further comprising adding one or more viscosity increasing agents.  
     
     
         74 . The method of  claim 73  wherein the viscosity increasing agent comprises a mixture of cetyl and stearyl alcohols.

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