Compositions and kits for the removal of irritating compounds from bodily surfaces

Abstract

The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.

1 . A kit, comprising: 
 a) a first composition comprising capsaicin or a capsaicin analog; and    b) a second composition comprising a substance in which the capsaicin or capsaicin analog is soluble.    
     
     
         2 . The kit of  claim 1  wherein the second composition comprises a substance in which said capsaicin or analog has a solubility of at least about 10 percent w/w.  
     
     
         3 . The kit of  claim 1  wherein the second composition comprises a substance in which said capsaicin or analog has a solubility of at least about 20 percent w/w.  
     
     
         4 . The kit of  claim 1  wherein the second composition comprises a substance in which capsaicin or analog has a solubility of at least about 25 percent w/w.  
     
     
         5 . The kit of  claim 1  wherein the second composition comprises polyethylene glycol and a polyacrylate thickening polymer.  
     
     
         6 . The kit of  claim 1  wherein the second composition comprises: 
 a) about 60 to about 99 percent w/w polyethylene glycol (PEG);  
 b) about 0.1 to about 4.0 percent w/w polyacrylate thickening agent; and  
 c) the balance water; wherein the composition is at a pH between about 6.0 and about 8.0.  
 
     
     
         7 . The kit of  claim 6  wherein the second composition comprises 
 a) about 84 to about 94 percent w/w polyethylene glycol;  
 b) about 0.1 to about 2.0 percent w/w polyacrylate thickening agent; and  
 c) the balance water; wherein the composition is at a pH of about 7.0 to 7.5.  
 
     
     
         8 . The kit of  claim 7  wherein the second composition further comprises: 
 d) about 0.005 to about 0.05 percent w/w butylated hydroxyanisole; and  
 e) about 0.05 to about 0.5 percent w/w edetate sodium.  
 
     
     
         9 . The kit of  claim 1  further comprising a third composition, wherein said third composition comprises an anesthetic.  
     
     
         10 . The kit of  claim 1  further comprising instructions for use.  
     
     
         11 . The kit of  claim 1  wherein the first composition comprises capsaicin or a capsaicin analog at a concentration of about 0.001 to about 60 percent w/w.  
     
     
         12 . The kit of  claim 1  wherein the first composition comprises capsaicin or a capsaicin analog at a concentration of about 1.0 to about 10 percent w/w.  
     
     
         13 . The kit of  claim 1  wherein the first composition comprises capsaicin or a capsaicin analog at a concentration of about 5 to about 10 percent w/w.  
     
     
         14 . The kit of  claim 1  wherein the first composition comprises capsaicin or a capsaicin analog contained in a patch.  
     
     
         15 . The kit of  claim 14  wherein the capsaicin or analog is present in the patch at an amount of about 0.64 mg/cm 2 .  
     
     
         16 . A kit, comprising: 
 a) a first composition comprising a patch comprising capsaicin or capsaicin analog at an amount of about 0.64 mg/cm 2 ;    b) a second composition comprising a cleansing gel comprising: 
 i) about 84 to about 94 percent w/w polyethylene glycol;  
 ii) about 0.1 to about 2.0 percent w/w polyacrylate thickening agent; and  
 iii) about 0.005 to about 0.05 percent w/w butylated hydroxyanisole;  
 iv) about 0.05 to about 0.5 percent w/w edetate sodium; and  
 v) the balance water; wherein the second composition is at a pH of about 7.0 to 7.7.  
   
     
     
         17 . A composition for cleansing a bodily surface comprising: 
 a) about 60 to about 99 percent w/w polyethylene glycol (PEG);    b) about 0.1 to about 4.0 percent w/w polyacrylate thickening agent; and    c) the balance water; wherein the composition is at a pH between about 6.0 and about 8.0.    
     
     
         18 . The composition of  claim 17  comprising: 
 a) about 84 to about 94 percent w/w polyethylene glycol (PEG);  
 b) about 0.1 to about 2.0 percent w/w polyacrylate thickening agent; and  
 c) the balance water; wherein the composition is at a pH between about 7.0 and about 7.7.  
 
     
     
         19 . The composition of  claim 18  further comprising a stabilizer.  
     
     
         20 . The composition of  claim 19  further comprising a cooling agent.  
     
     
         21 . The composition of  claim 19  comprising: 
 a) about 87 to about 91 percent w/w polyethylene glycol;  
 b) about 0.3 to about 1.5 percent w/w polyacrylate thickening agent;  
 c) about 0.01 to about 0.03 percent w/w butylated hydroxyanisole;  
 d) about 0.02 to about 0.2 percent w/w edetate sodium; and  
 e) the balance water; wherein the composition is at a pH of about 7.0 to about 7.7.  
 
     
     
         22 . The composition of  claim 21  comprising 
 a) about 89.08 percent w/w PEG 300;  
 b) about 1.0 percent w/w polyacrylate thickening agent;  
 c) about 0.02 percent w/w butylated hydroxyanisole;  
 d) about 0.1 percent w/w disodium edetate; and  
 e) the balance water; wherein the composition is at a pH of about 7.5.  
 
     
     
         23 . A method for treating pain in an individual in an area of the body affected by pain, comprising: 
 a) administering an afferent nerve fiber blocking regional anesthetic to the affected area;    b) affixing to the affected area a device, wherein said device comprises a skin-adherent patch, the patch including a reservoir comprising a therapeutic formulation whereby said formulation is continuously provided to the surface of the skin for a predetermined period of time, wherein said formulation comprises capsaicin or a capsaicin analog in a total concentration from greater than about 5% to 10% by weight of the formulation, wherein a single administration of said patch affords significant relief of said pain to said individual for at least several weeks; and    c) cleansing the area to which the patch of step b) has been applied by 
 i) applying to the area a composition comprising about 80 to about 99 percent w/w polyethylene glycol; about 0.1 to about 2.0 percent w/w polyacrylate thickening agent; and the balance water; wherein the composition is at a pH of about 7.0 to about 7.7; and  
 ii) removing the composition of step (c) from the area.  
   
     
     
         24 . A method for cleansing a bodily surface that has been contacted with an irritating or painful substance, comprising: 
 a) applying to the bodily surface a composition comprising: 
 i) about 80 to about 99 percent w/w polyethylene glycol;  
 ii) about 0.1 to about 2.0 percent w/w polyacrylate thickening agent; and  
 iii) the balance water; wherein the composition is at a pH of about 7.0 to about 7.7; and  
   b) removing the composition of step (a) from the bodily surface.