Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation

Abstract

Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: wherein A, X, n, R 1 , R 2 , and R 3 are as described in the specification, and novel fluoro-substituted benzenesulfonyl compounds within Formula I.

What is claimed is:  
     
         1 . The compound of Formula I:  
       
         
           
           
               
               
           
         
         wherein:  
         A is a 5- or 6-member ring substituent selected from partially saturated or unsaturated heterocyclic and carbocyclic rings;  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 1  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, t-o or three radicals selected from C 1-2 -alk-yl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 2  is alkyl or amino; and  
         R 3  represents one or more radicals selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 1-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alklylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         2 . The compound of  claim 1  wherein: 
 R 2  is methyl or amino; and  
 R 3  represents one or more radicals selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)oxy, C 1-3 -alkoxy, C 1-3 -alkylthio, C 1-3 -alkylcarbonyl, C 1-3 -cycloalkyl, phenyl, C 1-3 -haloalkyl, 5- or 6-member ring heterocyclyl, C 3-6 -cycloalkenyl, phenyl-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxy-C 1-3 -alkyl, C 1-3 -alkoxyphenyl-C 1-3 -alkoxy-C 1-3 -alkyl, C 1-3 -alkoxycarbonyl-C 1-3 -alkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-phenylamino, N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-phenylamino, amino-C 1-3 -alkyl, C 1-3 -alkylamino-C 1-3 -alkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenyl-C 1-3 -alkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl;  
 or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
 
     
     
         3 . The compound of  claim 2  wherein A is a 5- or 6-member ring substituent selected from partially saturated or unsaturated heterocyclic rings.  
     
     
         4 . The compound of  claim 2  wherein A is a 5- or 6-member ring substituent selected from partially saturated or unsaturated carbocyclic rings.  
     
     
         5 . The compound of  claim 2  wherein A is a radical selected from thienyl, furyl, furanone, thiazolyl, oxothiazolyl, thioxothiazolyl, imidazolyl, benzofuryl, indenyl, benzothienyl, isoxazolyl, oxooxazolyl, pyrazolyl, cyclopentenyl, cyclopentadienyl, benzindazolyl, benzopyranopyrazolyl, phenyl, and pyridyl.  
     
     
         6 . The compound of  claim 2  wherein A is a radical selected from thienyl, furyl, furanone, thiazolyl, oxothiazolyl, thioxothiazolyl, imidazolyl, benzofuryl, indenyl, benzothienyl, isoxazolyl, pyrazolyl, cyclopentenyl, cyclopentadienyl, benzindazolyl, benzopyranopyrazolyl, phenyl, and pyridyl.  
     
     
         7 . The compound of  claim 2  wherein A is a radical selected from thienyl, furanone, isoxazolyl, pyrazolyl, cyclopentenyl and pyridinyl.  
     
     
         8 . The compound of  claim 2  wherein A is a radical selected from furanone, isoxazolyl, and pyrazolyl.  
     
     
         9 . The compound of  claim 6  wherein R 1  is optionally substituted cyclohexyl.  
     
     
         10 . The compound of  claim 6  wherein R 1  is optionally substituted pyridinyl.  
     
     
         11 . The compound of  claim 6  wherein R 1  is optionally substituted phenyl.  
     
     
         12 . The compound of  claim 6  wherein R 1  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio.  
     
     
         13 . The compound of  claim 6  wherein R 3  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
     
     
         14 . The compound of  claim 6  wherein 
 R 1  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio; and  
 R 3  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylarinocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
 
     
     
         15 . The compound of  claim 6  wherein 
 R 1  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from halo, cyano, C 1-2 -alkyl, C 1-2 -haloalkyl, C 1-2 -alkoxy, and C 1-2 -haloalkoxy; and  
 R 3  is a radical selected from hydrido, C 1-2 -alkyl, C 1-3 -alkoxy, C 1-3 -alkylcarbonyl, C 1-3 -haloalkyl, C 1-3 -hydroxyalkyl, and C 1-3 -alkoxycarbonyl.  
 
     
     
         16 . The compound of  claim 15  wherein 
 R 1  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro, bromo, and methoxy; and  
 R 3  is a radical selected from hydrido, methyl, methoxy, methylcarbonyl, trifluoromethyl, difluoromethyl, hydroxymethyl, and methoxycarbonyl.  
 
     
     
         17 . The compound of  claim 1  having Formula II:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 4  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 5  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 6  is methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         18 . The compound of  claim 17  wherein: 
 R 5  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)oxy, C 1-3 -alkoxy, C 1-3 -alkylthio, C 1-3 -alkylcarbonyl, C 3-6 -cycloalkyl, phenyl, C 1-3 -haloalkyl, 5- or 6-member ring heterocyclyl, C 3-6 -cycloalkenyl, phenyl]-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 1-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxy-C 1-3 -alkyl, C 1-3 -alkoxyphenyl-C 1-3 -alkoxy-C 1-3 -alkyl, C 1-3 -alkoxycarbonyl-C 1-3 -alkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-phenylamino, N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-phenylamino, amino-C 1-3 -alkyl, C 1-3 -alkylamino-C 1-3 -alkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenyl-C 1-3 -alkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl;  
 or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
 
     
     
         19 . The compound of  claim 18  wherein R 4  is optionally substituted cyclohexyl.  
     
     
         20 . The compound of  claim 18  wherein R 4  is optionally substituted pyridinyl.  
     
     
         21 . The compound of  claim 18  wherein R 4  is optionally substituted phenyl.  
     
     
         22 . The compound of  claim 18  wherein R 4  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio.  
     
     
         23 . The compound of  claim 18  wherein R 5  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
     
     
         24 . The compound of  claim 18  wherein: 
 R 4  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio; and  
 R 5  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenyl methyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
 
     
     
         25 . The compound of  claim 24  having Formula IIA:  
       
         
           
           
               
               
           
         
         wherein R 4 , R 5  and R 6  are as defined in  claim 24 .  
       
     
     
         26 . The compound of  claim 24  having Formula IIB:  
       
         
           
           
               
               
           
         
         wherein R 4 , R 5  and R 6  are as defined in  claim 24 .  
       
     
     
         27 . The compound of  claim 18  wherein: 
 R 4  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from halo, cyano, C 1-2 -alkyl, C 1-2 -haloalkyl, C 1-2 -alkoxy, and C 1-2 -haloalkoxy; and  
 R 5  is a radical selected from hydrido, C 1-2 -alkyl, C 1-3 -alkoxy, C 1-3 -alkylcarbonyl, C 1-3 -haloalkyl, C 1-3 -hydroxyalkyl, and C 1-3 -alkoxycarbonyl.  
 
     
     
         28 . The compound of  claim 18  wherein 
 R 4  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro, bromo, and methoxy; and  
 R 5  is a radical selected from hydrido, methyl, methoxy, methylcarbonyl, trifluoromethyl, difluoromethyl, hydroxymethyl, and methoxycarbonyl.  
 
     
     
         29 . The compound of  claim 1  having Formula IIC  
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         30 . The compound of  claim 1  having Formula IID  
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         31 . The compound of  claim 17  selected from compounds and their pharmaceutically-acceptable salts, tautomers and prodrugs thereof, of the group consisting of 
 5-phenyl-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-chloro-5-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3, 5-difluoro-5-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-chlorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-chlorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-bromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-bromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,5-difluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-fluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-bromo-5-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,4-dichlorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,4-dibromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,4-difluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,5-dichlorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,5-dibromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,5-difluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole,  
 5-(3-chloro-4-fluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-chloro-4-methylphenyl)-1-[3.5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole,  
 5-(3-bromo-4-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,5-difluoro-4-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,4-dimethylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-trifluoromethoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole,  
 5-(3-methyl-4-trifluoromethoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-trifluoromethoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-trifluoromethoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-cyano-4-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-cyano-3-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-cyanophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-cyanophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-chloro-4-methoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-chloro-3-methoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 -(2-methylpyridin-6-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(2-methylthiazol-4-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-methylthiazol-2-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-pyridinyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(5-methylpyridin-3-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 3-cyclohexyl-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 3-cyclopentyl-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-phenyl-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-chlorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-chlorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 5-(3-bromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-bromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-fluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-fluorophenyl)-1-[3.5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methylphenyl)-1-[3,5-difluoro-4-(methyl sulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-cyanophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-cyanophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-trifluoromethylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 5-(4-trifluoromethylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-trifluoromethoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 5-(4-trifluoromethoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,4-dichlorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,4-dibromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,4-difluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,5-dichlorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,5-dibromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,5-difluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,4-dimethylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,5-dimethylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-chlorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-chlorophenyl)-1-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-fluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-fluorophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-bromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-bromophenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-trifluoromethylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-trifluoromethylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-trifluoromethoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-trifluoromethoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-cyano-4-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-cyano-3-methylphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 5-(3-chloro-4-methoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-chloro-3-methoxyphenyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-6-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 5-(2-methylthiazol-4-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methylthiazol-2-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 5-(2-methylpyridin-3-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-pyridinyl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(5-methylpyridin-3-yl)-1-[3, S-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-cyclohexyl-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-cyclopentyl-1-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-phenyl-5-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-chlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-chlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-bromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-bromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-fluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-fluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-methylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-cyanophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-cyanophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-trifluoromethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-trifluoromethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-trifluoromethoxyphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-trifluoromethoxyphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,4-dichlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,4-dibromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,4-difluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,5-dichlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,5-dibromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,5-difluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,4-dimethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,5-dimethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-chlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-chlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-fluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-fluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole,  
 1-(3-methyl-4-bromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole,  
 1-(4-methyl-3-bromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-trifluoromethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole,  
 1-(4-methyl-3-trifluoromethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole,  
 1-(3-methyl-4-trifluoromethoxyphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-trifluoromethoxyphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-cyano-4-methylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-cyano-3-methylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-chloro-4-methoxyphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-chloro-3-methoxyphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-6-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylthiazol-4-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methylthiazol-2-yl)-5-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-pyridinyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(5-methylpyridin-3-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-cyclohexyl-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-cyclopentyl-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-phenyl-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-chlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-chlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-bromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-bromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-fluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-fluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-cyanophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-cyanophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-trifluoromethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-trifluoromethylphenyl)-5-[3-5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-trifluoromethoxyphenyl)-5-[3-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-trifluoromethoxyphenyT)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,4-dichlorophenyl)-5-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,4-dibromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,4-difluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,5-dichlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,5-dibromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,5-difluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,4-dimethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,5-dimethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-chlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-chlorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-fluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-fluorophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-bromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-bromophenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-trifluoromethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-trifluoromethylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-trifluoromethoxyphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-trifluoromethoxyphenyl)-5-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-cyano-4-methylphenyl)-5′-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-cyano-3-methylphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-chloro-4-methoxyphenyl)-5-[[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-chloro-3-methoxyphenyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-6-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylthiazol-4-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole; 1-(4-methylthiazol-2-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-pyridinyl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(5-methylpyridin-3-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-cyclohexyl-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-cyclopentyl-5-[3,5-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 2,6-difluoro-4-[1-phenyl-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-bromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide,  
 2,6-difluoro-4-[1-(4-bromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-fluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-fluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-cyanophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-cyanophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-trifluoromethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-trifluoromethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-trifluoromethoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-trifluoromethoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-dibromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-difluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-dibromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-difluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-dimethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-dimethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-fluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-fluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-bromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-bromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-trifluoromethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-trifluoromethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-trifluoromethoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-trifluoromethoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-cyano-4-methylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-cyano-3-methylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-chloro-4-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-chloro-3-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-6-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylthiazol-4-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methylthiazol-2-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-pyridinyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(5-methylpyridin-3-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-cyclopentyl-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-phenyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-cyanophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-cyanophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-dichlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-dibromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-difluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-dichlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-dibromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-difluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-dimethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-dimethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-cyano-4-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-cyano-3-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-chloro-4-methoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-chloro-3-methoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-6-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylthiazol-4-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methylthiazol-2-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-pyridinyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(5-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-cyclohexyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-cyclopentyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-phenyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-cyanophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-cyanophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-dichlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-dibromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-difluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-dichlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-dibromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-difluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,4-dimethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3,5-dimethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-bromophenyl)-3-(trifluoro)-H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[ ]-(4-methyl-3-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-methyl-4-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methyl-3-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-cyano-4-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-cyano-3-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-chloro-4-methoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-chloro-3-methoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-6-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylthiazol-4-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(4-methylthiazol-2-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(3-pyridinyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(5-methylps-ridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-cyclohexyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,6-difluoro-4-[1-cyclopentyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 5-phenyl-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-chloro-5-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,6-difluoro-5-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-chlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-chlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-bromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-bromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,6-difluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-fluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-bromo-5-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,4-dichlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 -(3,4-dibromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,4-difluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,5-dichlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,5-dibromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,6-difluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-chloro-4-fluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-chloro-4-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-bromo-4-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,6-difluoro-4-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3,4-dimethylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-trifluoromethoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-trifluoromethoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-trifluoromethoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-trifluoromethoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-cyano-4-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-cyano-3-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-cyanophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-cyanophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-chloro-4-methoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-chloro-3-methoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-6-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(2-methylthiazol-4-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-methylthiazol-2-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-pyridinyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(5-methylpyridin-3-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 3-cyclohexyl-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 3-cyclopentyl-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-phenyl-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-chlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-chlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 5-(3-bromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-bromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-fluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-fluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-cyanophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-cyanophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-trifluoromethylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-trifluoromethylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-trifluoromethoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-trifluoromethoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,4-dichlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,4-dibromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,4-difluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,5-dichlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 5-(3,5-dibromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,5-difluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,4-dimethylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3,5-dimethylphenyl)-1 [3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-chlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-chlorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-fluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-fluorophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-bromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-bromophenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-trifluoromethylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-trifluoromethylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-methyl-4-trifluoromethoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methyl-3-trifluoromethoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-cyano-4-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-cyano-3-methylphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-chloro-4-methoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-chloro-3-methoxyphenyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-6-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 5-(2-methylthiazol-4-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(4-methylthiazol-2-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(3-pyridinyl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(5-methylpyridin-3-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-(2-methylpyridin-3-yl)-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 5-cyclohexyl-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-815 pyrazole;  
 5-cyclopentyl-1-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-phenyl-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-chlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-chlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-bromophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(4-bromophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-fluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-fluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-methylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 5-(3-cyanophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-cyanophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-trifluoromethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-840 (trifluoromethyl)-1H-pyrazole;  
 1-(4-trifluoromethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-trifluoromethoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-trifluoromethoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,4-dichlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,4-dibromophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,4-difluorophenyl)-5-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,5-dichlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,5-dibromophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,5-difluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,4-dimethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3,5-dimethylphenyl)-5-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-chlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-chlorophenyl)-5-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-fluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-fluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-bromophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-bromophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-trifluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-trifluoromethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-trifluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-trifluoromethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-trifluoromethoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-trifluoromethoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-cyano-4-methylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-cyano-3-methylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-chloro-4-methoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-chloro-3-methoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-6-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylthiazol-4-yl)-5-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(4-methylthiazol-2-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(3-pyridinyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(5-methylpyridin-3-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-cyclohexyl-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-cyclopentyl-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;  
 1-phenyl-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-chlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-chlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-bromophenyl)-5-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-bromophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-fluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-fluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-cyanophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-cyanophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-trifluoromethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-trifluoromethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-trifluoromethoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-trifluoromethoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,4-dichlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,4-dibromophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,4-difluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,5-dichlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,5-dibromophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,5-difluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,4-dimethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3,5-dimethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-chlorophenyl)—5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-chlorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole,  
 1-(3-methyl-4-fluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-fluorophenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-bromophenyl)-5-[3′, 6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-bromophenyl)—5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-trifluoromethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-trifluoromethylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-methyl-4-trifluoromethoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methyl-3-trifluoromethoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-cyano-4-methylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-cyano-3-methylphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-chloro-4-methoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-chloro-3-methoxyphenyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-6-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylthiazol-4-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(4-methylthiazol-2-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(3-pyridinyl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(5-methylpyridin-3-yl)-5-[3,6-difluoro-4-(methyl sulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-(2-methylpyridin-3-yl)-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-cyclohexyl-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 1-cyclopentyl-5-[3,6-difluoro-4-(methylsulfonyl)phenyl]-3-(difluoromethyl)-1H-pyrazole;  
 2,5-difluoro-4-[1-phenyl-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-bromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-bromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-fluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-fluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-cyanophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-cyanophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-trifluoromethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-trifluoromethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-trifluoromethoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-trifluoromethoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,4-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,4-dibromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,4-difluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,5-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,5-dibromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,5-difluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,4-dimethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,5-dimethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-fluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-fluorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-bromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-bromophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-trifluoromethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-trifluoromethylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-trifluoromethoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-trifluoromethoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-cyano-4-methylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-cyano-3-methylphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-chloro-4-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-chloro-3-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylpyridin-6-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylthiazol-4-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methylthiazol-2-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-pyridinyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(5-methylpyridin-3-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-cyclopentyl-3-(difluoromethyl)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-phenyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-chlorophenyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-cyanophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-cyanophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,4-dichlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,4-dibromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,4-difluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,5-dichlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,5-dibromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,5-difluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,4-dimethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3,5-dimethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-chlorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-fluorophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-bromophenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-trifluoromethylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-methyl-4-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methyl-3-trifluoromethoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-cyano-4-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-cyano-3-methylphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-chloro-4-methoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-chloro-3-methoxyphenyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylpyridin-6-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylthiazol-4-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(4-methylthiazol-2-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(3-pyridinyl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(5-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-(2-methylpyridin-3-yl)-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide;  
 2,5-difluoro-4-[1-cyclohexyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide; and  
 2,5-difluoro-4-[1-cyclopentyl-3-(trifluoro)-1H-pyrazol-5-yl]benezenesulfonamide.  
 
     
     
         32 . The compound of  claim 1  having Formula III:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 7  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 8  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylarmino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 9  is methyl or amino,  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         33 . The compound of  claim 32  wherein: 
 R 8  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)oxy, C 1-3 -alkoxy, C 1-3 -alkylthio, C 1-3 -alkylcarbonyl, C 3-6 -cycloalkyl, phenyl, C 1-3 -haloalkyl, 5- or 6-member ring heterocyclyl, C 3-6 -cycloalkenyl, phenyl-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-1 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 1-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxy-C 1-3 -alkyl, C 1-3 -alkoxyphenyl-C 1-3 -alkoxy-C 1-3 -alkyl, C 1-3 -alkoxycarbonyl-C 1-3 -alkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-phenylamino, N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino, N-(C 3 -alkyl)-N-phenylamino, amino-C 3 -alkyl, C 1-3 -alkylamino-C 1-3 -alkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenyl-C 1-3 -alkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl;  
 or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
 
     
     
         34 . The compound of  claim 33  wherein R 7  is optionally substituted cyclohexyl.  
     
     
         35 . The compound of  claim 33  wherein R 7  is optionally substituted pyridinyl.  
     
     
         36 . The compound of  claim 33  wherein R 7  is optionally substituted phenyl.  
     
     
         37 . The compound of  claim 33  wherein R 7  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio.  
     
     
         38 . The compound of  claim 33  wherein R 8  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
     
     
         39 . The compound of  claim 33  wherein: 
 R 7  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio; and  
 R 8  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomentyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
 
     
     
         40 . The compound of  claim 39  having Formula IIIA:  
       
         
           
           
               
               
           
         
         wherein R 7 , R 8  and R 9  are as defined in  claim 39 .  
       
     
     
         41 . The compound of  claim 33  wherein: 
 R 7  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from halo, cyano, C 1-2 -alkyl, C 1-2 -haloalkyl, C 1-2 -alkoxy, and C 1-2 -haloalkoxy; and  
 R 8  is a radical selected from hydrido, halogen, C 1-2 -alkyl, C 1-3 -alkoxy, C 1-3 -alkylcarbonyl, C 1-3 -haloalkyl, C 1-3 -hydroxyalkyl, and C 1-3 -alkoxycarbonyl.  
 
     
     
         42 . The compound of  claim 33  wherein 
 R 7  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro, bromo, iodo and methoxy; and  
 R 8  is a radical selected from hydrido, chloro, fluoro, bromo, cyano, methyl, methoxy, methylcarbonyl, trifluoromethyl, difluoromethyl, hydroxymethyl, and methoxycarbonyl.  
 
     
     
         43 . The compound of  claim 1  having Formula IV:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 10  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 11  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-1 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl;  
         R 12  is a methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         44 . The compound of  claim 4 , wherein: 
 R 11  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)oxy, C 1-3 -alkoxy, C 1-3 -alkylthio, C 1-3 -alkylcarbonyl, C 3-1 -cycloalkyl, phenyl, C 1-3 -haloalkyl, 5- or 6-member ring heterocyclyl, C 3-6 -cycloalkenyl, phenyl-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 1-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alk-yl, phenylthio-C 1-3 -alkyl, phenyloxy-C 1-3 -alkyl, C 1-3 -alkoxyphenyl-C 1-3 -alkoxy-C 1-3 -alkyl, C 1-3 -alkoxycarbonyl-C 1-3 -alkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-13 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-phenylamino, N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-phenylamino, amino-C 1-3 -alkyl, C 1-3 -alkylamino-C 1-3 -alkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenyl-C 1-3 -alkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl;    or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.    
     
     
         45 . The compound of  claim 44  wherein R 10  is optionally substituted cyclohexyl.  
     
     
         46 . The compound of  claim 44  wherein R 10  is optionally substituted pyridinyl.  
     
     
         47 . The compound of  claim 44  wherein R 10  is optionally substituted phenyl.  
     
     
         48 . The compound of  claim 44  wherein R 10  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio.  
     
     
         49 . The compound of  claim 44  wherein R 11  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
     
     
         50 . The compound of  claim 44  wherein: 
 R 10  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio; and  
 R 11  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
 
     
     
         51 . The compound of  claim 50  having Formula IVA:  
       
         
           
           
               
               
           
         
         wherein R 10 , R 11  and R 12  are as defined in  claim 50 .  
       
     
     
         52 . The compound of  claim 50  having Formula IVB:  
       
         
           
           
               
               
           
         
         wherein R 10 , R 11  and R 12  are as defined in  claim 50 .  
       
     
     
         53 . The compound of  claim 44  wherein: 
 R 10  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from halo, cyano, C 1-2 -alkyl, C 1-2 -haloalkyl, C 1-2 -alkoxy, and C 1-2 -haloalkoxy; and  
 R 11  is a radical selected from hydrido, C 1-2 -alkyl, C 1-3 -alkoxy, C 1-3 -alkylcarbonyl, C 1-3 -haloalkyl, C 1-3 -hydroxyalkyl, and C 1-3 -alkoxycarbonyl.  
 
     
     
         54 . The compound of  claim 44  wherein 
 R 10  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro, bromo, and methoxy; and  
 R 11  is a radical selected from hydrido, methyl, methoxy, methylcarbonyl, trifluoromethyl, difluoromethyl, hydroxymethyl, and methoxycarbonyl.  
 
     
     
         55 . The compound of  claim 50  having Formula IVC:  
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         56 . The compound of  claim 44  selected from compounds and their pharmaceutically-acceptable salts, tautomers and prodrugs thereof, of the group consisting of 
 2,6-difluoro-4-[3-phenyl-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-bromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-bromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-fluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-fluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyanophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyanophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-trifluoromethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-trifluoromethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-trifluoromethoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide,  
 2,6-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dichlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dibromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-difluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dichlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dibromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-difluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dimethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dimethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-chlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-chlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-fluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-fluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-bromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-bromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-6-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylthiazol-4-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylthiazol-2-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-pyridinyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(5-methylpyridin-3-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-cyclohexyl-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-cyclopentyl-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-phenyl-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chloro-5-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-fluoro-5-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chlorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chlorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-bromophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-bromophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-fluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-fluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-bromo-5-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dichlorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dibromophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-difluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dichlorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dibromophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-difluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chloro-4-fluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chloro-4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-bromo-4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-fluoro-4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dimethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-trifluoromethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-trifluoromethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyanophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyanophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-6-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylthiazol-4-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylthiazol-2-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-pyridinyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(5-methylpyridin-3-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 3-phenyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-trifluoromethylphenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,4-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,4-dibromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,4-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,5-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,5-dibromophenyl)-4-[3), 5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,5-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,4-dimethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,5-dimethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-cyano-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-cyano-3-methylphenyl)-4-[3.5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-chloro-4-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-chloro-3-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylpyridin-6-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylthiazol-4-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methylthiazol-2-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-pyridinyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(5-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-cyclohexyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-cyclopentyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole,  
 3-phenyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,4-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,4-dibromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,4-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,5-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,5-dibromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,5-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 -3-(3,4-dimethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,5-dimethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-cyano-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-cyano-3-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-chloro-4-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-chloro-3-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylpyridin-6-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylthiazol-4-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methylthiazol-2-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-pyridinyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(5-methylpyridin-3-yl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-cyclohexyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-cyclopentyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-phenyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chloro-5-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-fluoro-5-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chlorophenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-bromophenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-difluorophenyl)-4-[3.5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-methylphenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-bromo-5-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,4-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,4-dibromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,4-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-dibromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-difluorophenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chloro-4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chloro-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-bromo-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-difluoro-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,4-dimethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-cyano-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-cyano-3-methylphenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chloro-4-methoxyphenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-chloro-3-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylpyridin-6-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylthiazol-4-yl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-methylthiazol-2-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylpyridin-3-y!)-4-[3.5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-pyridinyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(5-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-cyclohexyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-cyclopentyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-phenyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole,  
 3-(3-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,4-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,4-dibromophenyl)-4-[33,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,4-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,5-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,5-dibromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,5-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,4-dimethylphenyl)-4-[33,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,5-dimethylphenyl)-4-[33,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-bromophenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-trifluoromethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-cyano-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-cyano-3-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-chloro-4-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-chloro-3-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylpyridin-6-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylthiazol-4-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methylthiazol-2-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-pyridinyl) 4 -[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(5-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-cyclohexyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-cyclopentyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 2,6-difluoro-4-[3-phenyl-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-bromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-bromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-fluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-fluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyanophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyanophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-trifluoromethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-trifluoromethoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dibromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-difluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dichlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dibromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-difluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dimethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dimethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-chlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-chorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-fluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-fluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-bromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-bromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-6-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylthiazol-4-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylthiazol-2-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-pyridinyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(5-methylpyridin-3-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-phenyl-5-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-bromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-bromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-fluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-fluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyanophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyanophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-trifluoromethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-trifluoromethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-trifluoromethoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dichlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dibromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-difluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dichlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dibromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dimethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dimethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-chlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-chlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-fluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-fluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-bromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-bromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-6-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylthiazol-4-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylthiazol-2-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-pyridinyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(5-methylpyridin-3-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-phenyl-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-bromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-bromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-fluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-fluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyanophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyanophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide,  
 2,6-difluoro-4-[3-(3-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-trifluoromethoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dichlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dibromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-difluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide,  
 2,6-difluoro-4-[3-(3,5-dichlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dibromophenyl)-5-trifluoromethylisoxazol-4-yl]-benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-difluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,4-dimethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3,5-dimethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-chlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-chlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-fluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-fluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-bromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-bromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-6-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylthiazol-4-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(4-methylthiazol-2-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(3-pyridinyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(5-methylpyridin-3-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,6-difluoro-4-[3-(2-methylpyridin-3-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-phenyl-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chlorophenyl-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-chlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-bromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-bromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-fluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-fluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyanophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyanophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-trifluoromethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-trifluoromethoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dichlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dibromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-difluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dichlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dibromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-difluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dimethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dimethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-chlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-chlorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-fluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-fluorophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-bromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-bromophenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide,  
 2,5-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-6-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylthiazol-4-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylthiazol-2-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-pyridinyl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(5-methylpyridin-3-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-cyclohexyl-5-fluoromethylisoxazol-4-yl]benezenesulfonamide, 2,5-difluoro-4-[3-cyclopentyl-5-fluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-phenyl-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chloro-5-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-fluoro-5-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chlorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-chlorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-bromophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-bromophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-fluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-fluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-bromo-5-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide,  
 2,5-difluoro-4-[3-(3,4-dichlorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dibromophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-difluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dichlorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dibromophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-difluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chloro-4-fluorophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chloro-4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-bromo-4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-fluoro-4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dimethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-trifluoromethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyanophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyanophenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-6-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylthiazol-4-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylthiazol-2-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-pyridinyl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(5-methylpyridin-3-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-difluoromethylisoxazol-4-yl]benezenesulfonamide;  
 3-phenyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-cyanophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-cyanophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-trifluoromethylphenyl)-4-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-trifluoromethoxyphenyl)-4-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,4-dichlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,4-dibromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,4-difluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,5-dichlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,5-dibromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,5-difluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,4-dimethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3,5-dimethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-fluorophenyl)-4-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-cyano-4-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-cyano-3-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-chloro-4-methoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-chloro-3-methoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylpyridin-6-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylthiazol-4-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(4-methylthiazol-2-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(3-pyridinyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(5-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-cyclohexyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-cyclopentyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-hydroxymethylisoxazole;  
 3-phenyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-cyanophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-cyanophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,4-dichlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,4-dibromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,4-difluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5 fluoromethylisoxazole;  
 3-(3,5-dichlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,5-dibromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,6-difluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,4-dimethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3,5-dimethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-cyano-4-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-cyano-3-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-chloro-4-methoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-chloro-3-methoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylpyridin-6-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylthiazol-4-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(4-methylthiazol-2-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(3-pyridinyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(5-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-cyclohexyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-cyclopentyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-fluoromethylisoxazole;  
 3-phenyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chloro-5-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-fluoro-5-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-chlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-bromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-bromo-5-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,4-dichlorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,4-dibromophenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,4-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-dichlorophenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-dibromophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-difluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chloro-4-fluorophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chloro-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-bromo-4-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,5-difluoro-4-methylphenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3,4-dimethylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-cyano-4-methylphenyl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-cyano-3-methylphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-cyanophenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-chloro-4-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-chloro-3-methoxyphenyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylpyridin-6-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylthiazol-4-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(4-methylthiazol-2-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[35, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(3-pyridinyl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(5-methylpyridin-3-yl)-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3, 5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-cyclohexyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-cyclopentyl-4-[3,5-difluoro-4-(methylsulfonyl)phenyl]-5-difluoromethylisoxazole;  
 3-phenyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole- 
 3-(4-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-cyanophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-cyanophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole,  
 3-(3,4-dichlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,4-dibromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,4-difluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,5-dichlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,5-dibromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,6-difluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,4-dimethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3,5-dimethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-chlorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-fluorophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-bromophenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-trifluoromethylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-methyl-4-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methyl-3-trifluoromethoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-cyano-4-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-cyano-3-methylphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-chloro-4-methoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-chloro-3-methoxyphenyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylpyridin-6-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylthiazol-4-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(4-methylthiazol-2-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(3-pyridinyl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(5-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-(2-methylpyridin-3-yl)-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-cyclohexyl-4-[3,6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 3-cyclopentyl-4-[3, 6-difluoro-4-(methylsulfonyl)phenyl]-5-methylisoxazole;  
 2,5-difluoro-4-[3-phenyl-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-chlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-bromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-bromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-fluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-fluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyanophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyanophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-trifluoromethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-trifluoromethoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dichlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dibromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-difluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dichlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dibromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-difluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dimethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dimethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-chlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-chlorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-fluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-fluorophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-bromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-bromophenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-6-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylthiazol-4-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylthiazol-2-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-pyridinyl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(5-methylpyridin-3-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-hydroxymethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-phenyl-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-chlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-bromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-bromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-fluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-fluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyanophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyanophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-trifluoromethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-trifluoromethoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dichlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dibromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-difluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dichlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dibromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-difluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dimethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dimethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-chlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-chlorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-fluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-fluorophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-bromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-bromophenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-6-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylthiazol-4-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylthiazol-2-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-pyridinyl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(5-methylpyridin-3-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-methylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-phenyl-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-chlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-bromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-bromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-fluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-fluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyanophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyanophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-trifluoromethoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-trifluoromethoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dichlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dibromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-difluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dichlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dibromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-difluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,4-dimethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3,5-dimethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-chlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-chlorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-fluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-fluorophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-bromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-bromophenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-methyl-4-trifluoromethoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methyl-3-trifluoromethoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-cyano-4-methylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-cyano-3-methylphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-chloro-4-methoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-chloro-3-methoxyphenyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-6-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylthiazol-4-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(4-methylthiazol-2-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(3-pyridinyl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide;  
 2,5-difluoro-4-[3-(5-methylpyridin-3-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide; and  
 2,5-difluoro-4-[3-(2-methylpyridin-3-yl)-5-trifluoromethylisoxazol-4-yl]benezenesulfonamide.  
 
     
     
         57 . The compound of  claim 1  having Formula V:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 13  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 14  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, arinocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 15  is methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof;  
         provided that when R 13  is 4-bromophenyl, R 14  is not hydrogen.  
       
     
     
         58 . The compound of  claim 57  wherein: 
 R 14  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)oxy, C 1-3 -alkoxy, C 1-3 -alkylthio, C 1-3 -alkylcarbonyl, C 1-3 -cycloalkyl, phenyl, C 1-3 -haloalkyl, 5- or 6-member ring heterocyclyl, C 3-6 -cycloalkenyl, phenyl-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxy-C 1-3 -alkyl, C 1-3 -alkoxyphenyl-C 1-3 -alkoxy-C 1-3 -alkyl, C 1-3 -alkoxycarbonyl-C 1-3 -alkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-phenylamino, N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-phenylamino, amino-C 1-3 -alkyl, C 1-3 -alkylamino-C 1-3 -alkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenyl-C 1-3 -alkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl,  
 or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
 
     
     
         59 . The compound of  claim 58  wherein R 13  is optionally substituted cyclohexyl.  
     
     
         60 . The compound of  claim 58  wherein R 13  is optionally substituted pyridinyl.  
     
     
         61 . The compound of  claim 58  wherein R 13  is optionally substituted phenyl.  
     
     
         62 . The compound of  claim 58  wherein R 13  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio.  
     
     
         63 . The compound of  claim 58  wherein R 14  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylamino methyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methyl sulfinyl, methylsulfonyl, amino sulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
     
     
         64 . The compound of  claim 58  wherein: 
 R 13  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio; and  
 R 14  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenyl amino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
 
     
     
         65 . The compound of  claim 64  having Formula VA:  
       
         
           
           
               
               
           
         
         wherein R 13 , R 14  and R 15  ate as defined in  claim 64 .  
       
     
     
         66 . The compound of  claim 64  having Formula VB:  
       
         
           
           
               
               
           
         
         wherein R 13 , R 14  and R 15  are as defined in  claim 64 .  
       
     
     
         67 . The compound of  claim 58  wherein: 
 R 13  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from halo, cyano, C 1-2 -alkyl, C 1-2 -haloalkyl, C 1-2 -alkoxy, and C 1-2 -haloalkoxy; and  
 R 14  is a radical selected from hydrido, C 1-2 -alkyl, C 1-3 -alkoxy, C 1-3 -alkylcarbonyl, C 1-13 -haloalkyl, C 1-3 -hydroxyalkyl, and C 1-3 -alkoxycarbonyl.  
 
     
     
         68 . The compound of  claim 58  wherein 
 R 13  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro, bromo, and methoxy; and  
 R 14  is a radical selected from hydrido, methyl, methoxy, methylcarbonyl, trifluoromethyl, difluoromethyl, hydro. xmethyl, and methoxycarbonyl.  
 
     
     
         69 . The compound of  claim 64  having Formula VC:  
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         70 . The compound of  claim 1  having Formula VI:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 16  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 17  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 13  is methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         71 . The compound of  claim 70  wherein: 
 R 17  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)oxy, C 1-3 -alkoxy, C 1-3 -alkylthio, C 1-3 -alkylcarbonyl, C 3-6 -cycloalkyl, phenyl, C 1-3 -haloalkyl, 5- or 6-member ring heterocyclyl, C 3-6 -cycloalkenyl, phenyl-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxy-C 1-3 -alkyl, C 1-3 -alkoxyphenyl-C 1-3 -alkoxy-C 1-3 -alkyl, C 1-3 -alkoxycarbonyl-C 1-3 -alkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-phenylamino, N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-phenylamino, amino-C 1-13 -alkyl, C 1-3 -alkylamino-C 1-3 -alkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenyl-C 1-3 -alkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl;  
 or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
 
     
     
         72 . The compound of  claim 71  wherein R 16  is optionally substituted cyclohexyl.  
     
     
         73 . The compound of  claim 71  wherein R 16  is optionally substituted pyridinyl.  
     
     
         74 . The compound of  claim 71  wherein R 16  is optionally substituted phenyl.  
     
     
         75 . The compound of  claim 71  wherein R 16  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio.  
     
     
         76 . The compound of  claim 71  wherein R 17  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
     
     
         77 . The compound of  claim 71  wherein: 
 R 16  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio; and  
 R 17  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylarminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylamino methyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
 
     
     
         78 . The compound of  claim 77  having Formula VIA:  
       
         
           
           
               
               
           
         
         wherein R 16 , R 17  and R 18  are as defined in  claim 77 .  
       
     
     
         79 . The compound of  claim 71  wherein: 
 R 16  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from halo, cyano, C 1-2 -alkyl, C 1-2 -haloalkyl, C 1-2 -alkoxy, and C 1-2 -haloalkoxy; and  
 R 17  is a radical selected from hydrido, C 1-2 -alkyl, C 1-3 -alkoxy, C 1-3 -alkylcarbonyl, C 1-3 -haloalkyl, C 1-3 -hydroxyalkyl, and C 1-3 -alkoxycarbonyl.  
 
     
     
         80 . The compound of  claim 71  wherein 
 R 16  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro, bromo, and methoxy; and  
 R 17  is a radical selected from hydrido, methyl, methoxy, methylcarbonyl, trifluoromethyl, difluoromethyl, hydroymethyl, and methoxycarbonyl.  
 
     
     
         81 . The compound of  claim 77  having Formula VIB:  
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         82 . The compound of  claim 1  having Formula VII:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 19  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 20  is represents one or more radicals selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 21  is methyl or amino,  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         83 . The compound of  claim 82  wherein: 
 R 20  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)oxy, C 1-3 -alkoxy, C 1-3 -alkylthio, C 1-3 -alkylcarbonyl, C 3-6 -cycloalkyl, phenyl, C 1-3 -haloalkyl, 5- or 6-member ring heterocyclyl, C 3-6 -cycloalkenyl, phenyl-C 1-3 -alkyl, (5- or 6-member ring heterocyclyl)-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxy-C 1-3 -alkyl, C 1-3 -alkoxyphenyl-C 1-3 -alkoxy-C 1-3 -alkyl, C 1-3 -alkoxycarbonyl-C 1-3 -alkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-phenylamino, N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino, N-(C 1-3 -alkyl)-N-phenylamino, amino-C 1-3 -alkyl, C 1-3 -alkylamino-C 1-3 -alkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenyl-C 1-3 -alkylamino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenyl-C 1-3 -alkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl;  
 or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
 
     
     
         84 . The compound of  claim 83  wherein R 19  is optionally substituted cyclohexyl.  
     
     
         85 . The compound of  claim 83  wherein R 19  is optionally substituted pyridinyl.  
     
     
         86 . The compound of  claim 83  wherein R 19  is optionally substituted phenyl.  
     
     
         87 . The compound of  claim 83  wherein R 19  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio.  
     
     
         88 . The compound of  claim 83  wherein R 20  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonml, arminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
     
     
         89 . The compound of  claim 83  wherein: 
 R 19  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, cyano, carboxyl, methoxycarbonyl, hydroxyl, hydroxymethyl, trifluoromethoxy, amino, methylamino, phenylamino, nitro, methoxymethyl, methylsulfinyl, fluoro, chloro, bromo, methoxy and methylthio; and  
 R 20  is a radical selected from hydrido, fluoro, chloro, bromo, methyl, oxo, cyano, carboxyl, cyanomethyl, methoxy, methylthio, methylcarbonyl, phenyl, trifluoromethyl, difluoromethyl, phenylmethyl, methylthiomethyl, hydroxymethyl, methoxycarbonyl, ethoxycarbonyl, phenylcarbonyl, phenylmethylcarbonyl, methoxymethyl, phenylthiomethyl, phenyloxymethyl, methoxyphenylmethoxymethyl, methoxycarbonylmethyl, aminocarbonyl, aminocarbonylmethyl, methylaminocarbonyl, N-phenylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methylaminocarbonylmethyl, carboxymethyl, methylamino, N-phenylamino, N-(phenylmethyl)amino, N-methyl-N-(phenylmethyl)amino, N-methyl-N-phenylamino, aminomethyl, methylaminomethyl, N-phenylaminomethyl, N-phenylmethylaminomethyl, N-methyl-N-phenylmethylaminomethyl, N-methyl-N-phenylaminomethyl, phenyloxy, phenylmethoxy, phenylthio, phenylmethylthio, methylsulfinyl, methylsulfonyl, aminosulfonyl, methylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-methyl-N-phenylaminosulfonyl.  
 
     
     
         90 . The compound of  claim 89  having Formula VIIA:  
       
         
           
           
               
               
           
         
         wherein R 19 , R 20  and R 21  are as defined in  claim 89 .  
       
     
     
         91 . The compound of  claim 83  wherein: 
 R 19  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from halo, cyano, C 1-2 -alkyl, C 1-2 -haloalkyl, C 1-2 -alkoxy, and C 1-2 -haloalkoxy; and  
 R 20  is a radical selected from hydrido, C 1-2 -alkyl, C 1-3 -alkoxy, C 1-3 -alkylcarbonyl, C 1-3 -haloalkyl, C 1-3 -hydroxyalkyl, and C 1-3 -alkoxycarbonyl.  
 
     
     
         92 . The compound of  claim 83  wherein 
 R 19  is cyclohexyl or phenyl, wherein said cyclohexyl and phenyl may be optionally substituted with one, two or three radicals selected from methyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro, bromo, and methoxy; and  
 R 20  is a radical selected from hydrido, methyl, methoxy, methylcarbonyl, trifluoromethyl, difluoromethyl, hydroxymethyl, and methoxycarbonyl.  
 
     
     
         93 . The compound of  claim 89  having Formula VIIB:  
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         94 . A compound of  claim 1  wherein R 2  is amino, the compound is a prodrug, and R 2  is substituted with an acyl group.  
     
     
         95 . The compound of  claim 94  wherein R 2  is  
       
         
           
           
               
               
           
         
       
     
     
         96 . A pharmaceutical composition comprising a therapeutically-effective amount of a compound of  claim 1 .  
     
     
         97 . A pharmaceutical composition comprising a therapeutically-effective amount of a compound of  claim 17 .  
     
     
         98 . A pharmaceutical composition comprising a therapeutically-effective amount of a compound of  claim 32 .  
     
     
         99 . A pharmaceutical composition comprising a therapeutically-effective amount of a compound of  claim 43 .  
     
     
         100 . A pharmaceutical composition comprising a therapeutically-effective amount of a compound of  claim 57 .  
     
     
         101 . A pharmaceutical composition comprising a therapeutically-effective amount of a compound of  claim 70 .  
     
     
         102 . A pharmaceutical composition comprising a therapeutically-effective amount of a compound of  claim 82 .  
     
     
         103 . A pharmaceutical composition comprising a therapeutically-effective amount of a compound of  claim 94 .  
     
     
         104 . A method of treating inflammation, said method comprising administering to the subject having or susceptible to such inflammation or inflammation-associated disorder, a therapeutically-effective amount of a compound of Formula I  
       
         
           
           
               
               
           
         
         wherein:  
         A is a 5- or 6-member ring substituent selected from partially saturated or unsaturated heterocyclic and carbocyclic rings;  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 1  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio,  
         R 2  is methyl or amino; and  
         R 3  represents one or more radicals selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 13 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfonyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         105 . A method of  claim 104  wherein R 2  is amino, the compound is a prodrug, and R 2  is substituted with an acyl group.  
     
     
         106 . A method of  claim 105  wherein R 2  is  
       
         
           
           
               
               
           
         
       
     
     
         107 . The method of  claim 104  wherein the compound corresponds to Formula II:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 4  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 5  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -allyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylarainoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 6  is methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof;  
         provided that when R 1  is 4-bromophenyl and R 2  is methyl, R 3  is not hydrogen, cyano, trifluoromethyl or ethoxycarbonyl.  
       
     
     
         108 . The method of  claim 104  wherein the compound corresponds to Formula III:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 7  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 8  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 9  is methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         109 . The method of  claim 104  wherein the compound corresponds to Formula IV:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 10  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 11  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 12  is methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         110 . The method of  claim 104  wherein the compound corresponds to Formula V:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 13  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 14  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyallkyl, alkoxycarbonylallkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 15  is methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         111 . The method of  claim 104  wherein the compound corresponds to Formula VI:  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro,  
         n is an integer greater than or equal to 2;  
         R 16  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-3 -alkylthio;  
         R 17  is a radical selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoallcyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 18  is methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         112 . The method of  claim 104  wherein the compound corresponds to Formula VII  
       
         
           
           
               
               
           
         
         wherein:  
         X is fluoro;  
         n is an integer greater than or equal to 2;  
         R 19  is cyclohexyl, pyridinyl, or phenyl, wherein said cyclohexyl, pyridinyl, and phenyl may be optionally substituted with one, two or three radicals selected from C 1-2 -alkyl, C 1-2 -haloalkyl, cyano, carboxyl, C 1-2 -alkoxycarbonyl, hydroxyl, C 1-2 -hydroxyalkyl, C 1-2 -haloalkoxy, amino, C 1-2 -alkylamino, phenylamino, nitro, C 1-2 -alkoxy-C 1-2 -alkyl, C 1-2 -alkylsulfinyl, halo, C 1-2 -alkoxy and C 1-13 -alkylthio;  
         R 20  is represents one or more radicals selected from hydrido, halo, C 1-2 -alkyl, C 2-3 -alkenyl, C 2-3 -alkynyl, oxo, cyano, carboxyl, cyano-C 1-3 -alkyl, heterocyclyloxy, C 1-3 -alkoxy, C 1-3 -alkylthio, alkylcarbonyl, cycloalkyl, phenyl, C 1-3 -haloalkyl, heterocyclyl, cycloalkenyl, phenyl-C 1-3 -alkyl, heterocyclyl-C 1-3 -alkyl, C 1-3 -alkylthio-C 1-3 -alkyl, C 1-3 -hydroxyalkyl, C 1-3 -alkoxycarbonyl, phenylcarbonyl, phenyl-C 1-3 -alkylcarbonyl, phenyl-C 2-3 -alkenyl, C 1-3 -alkoxy-C 1-3 -alkyl, phenylthio-C 1-3 -alkyl, phenyloxyalkyl, alkoxyphenylalkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonyl-C 1-3 -alkyl, C 1-3 -alkylaminocarbonyl, N-phenylaminocarbonyl, N-(C 1-3 -alkyl)-N-phenylaminocarbonyl, C 1-3 -alkylaminocarbonyl-C 1-3 -alkyl, carboxy-C 1-3 -alkyl, C 1-3 -alkylamino, N-arylamino, N-aralkylamino, N-(C 1-3 -alkyl)-N-aralkylamino, N-(C 1-3 -alkyl)-N-arylamino, amino-C 1-3 -alkyl, C 1-3 -alkylaminoalkyl, N-phenylamino-C 1-3 -alkyl, N-phenyl-C 1-3 -alkylaminoalkyl, N-(C 1-3 -alkyl)-N-(phenyl-C 1-3 -alkyl)amino-C 1-3 -alkyl, N-(C 1-3 -alkyl)-N-phenylamino-C 1-3 -alkyl, phenyloxy, phenylalkoxy, phenylthio, phenyl-C 1-3 -alkylthio, C 1-3 -alkylsulfinyl, C 1-3 -alkylsulfonyl, aminosulfonyl, C 1-3 -alkylaminosulfonyl, N-phenylaminosulfonyl, phenylsulfonyl, and N-(C 1-3 -alkyl)-N-phenylaminosulfonyl; and  
         R 21  is methyl or amino;  
         or a pharmaceutically-acceptable salt, tautomer or prodrug thereof.  
       
     
     
         113 . The method of  claim 104  for use in the treatment of inflammation.  
     
     
         114 . The method of  claim 104  for use in the treatment of an inflammation-associated disorder.  
     
     
         115 . The method of  claim 114  wherein the inflammation-associated disorder is arthritis.  
     
     
         116 . The method of  claim 114  wherein the inflammation-associated disorder is pain.  
     
     
         117 . The method of  claim 114  wherein the inflammation-associated disorder is fever.  
     
     
         118 . A method of treating cancer, said method comprising administering to the subject having or susceptible to such cancer, a therapeutically-effective amount of a compound of  claim 104 .  
     
     
         119 . The method of  claim 118  wherein the compound is administered intravenously.  
     
     
         120 . The method of  claim 118  wherein the compound is administered intramuscularly.