US2004143856A1PendingUtilityA1

Placenta derived apoptotic factor

57
Assignee: ANAWRAHTA BIOTECH CO INC A TAIPriority: Oct 10, 2000Filed: Jan 15, 2004Published: Jul 22, 2004
Est. expiryOct 10, 2020(expired)· nominal 20-yr term from priority
Inventors:Wei-Yu LoShie-Liang Hsieh
C07K 14/47
57
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Claims

Abstract

The invention provides the nucleic acid and amino acid sequences of a novel human tumor-associated antigen, placenta derived apoptotic factor (PDAF), and the use of these sequences in the treatment of disorders associated with immune and cell proliferation.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . An isolated nucleic acid encoding a polypeptide or a degenerate sequences thereof, wherein the polypeptide is the amino acid sequence of SEQ ID NO:1.  
     
     
         2 . An isolated nucleic acid encoding a polypeptide or a degenerate sequences thereof, wherein the polypeptide is the amino acid sequence of SEQ ID NO:2.  
     
     
         3 . An isolated nucleic acid encoding a polypeptide or a degenerate sequences thereof, wherein the polypeptide is the amino acid sequence of SEQ ID NO:3.  
     
     
         4 . The isolated nucleic acid as claimed in  claim 1 , which is SEQ ID NO:4.  
     
     
         5 . The isolated nucleic acid as claimed in  claim 2 , which is SEQ ID NO:5.  
     
     
         6 . The isolated nucleic acid as claimed in  claim 3 , which is SEQ ID NO:6.  
     
     
         7 . An expression vector containing the nucleic acid sequences as claimed in  claim 1 .  
     
     
         8 . An expression vector containing the nucleic acid sequences as claimed in  claim 2 .  
     
     
         9 . An expression vector containing the nucleic acid sequences as claimed in  claim 3 .  
     
     
         10 . A host cell containing the vector of  claim 7 .  
     
     
         11 . A host cell containing the vector of  claim 8 .  
     
     
         12 . A host cell containing the vector of  claim 9 .  
     
     
         13 . A method for producing a polypeptide that contains the amino acid sequence of SEQ ID NO:1, the method comprising the steps of: 
 (a) culturing the host cell of  claim 10  under conditions suitable for the expression of the polypeptide; and    (b) recovering the polypeptide from the host cell culture.    
     
     
         14 . A method for producing a polypeptide that contains the amino acid sequence of SEQ ID NO:2, the method comprising the steps of: 
 (a) culturing the host cell of  claim 11  under conditions suitable for the expression of the polypeptide; and    (b) recovering the polypeptide from the host cell culture.    
     
     
         15 . A method for producing a polypeptide that contains the amino acid sequence of SEQ ID NO: 3, the method comprising the steps of: 
 (a) culturing the host cell of  claim 12  under conditions suitable for the expression of the polypeptide; and    (b) recovering the polypeptide from the host cell culture.    
     
     
         16 . A transgenic animal, which is introduced with a gene fragment containing the nucleic acid sequence of SEQ ID NO:4.  
     
     
         17 . A transgenic animal, which is introduced with a gene fragment containing the nucleic acid sequence of SEQ ID NO:5.  
     
     
         18 . A transgenic animal, which is introduced with a gene fragment containing the nucleic acid sequence of SEQ ID NO:6.

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