US2004152699A1PendingUtilityA1
Compounds
Assignee: ASTRAZENECA AND NPS PHARMACEUTPriority: Aug 9, 2002Filed: Aug 8, 2003Published: Aug 5, 2004
Est. expiryAug 9, 2022(expired)· nominal 20-yr term from priority
Inventors:Jalaj AroraLouise EdwardsMethvin IsaacDonald McleodAbdelmalik SlassiTomislav StefanacThomas StormannDavid WensboTao XinHelena GybackMartin JohanssonAnnika KersJohn MalmbergAlexander MinidisKarin OscarssonMangus WaldmanUlrika YngveChristoffer Osterwall
A61P 39/00A61P 43/00A61P 9/00A61P 25/16A61P 27/02A61P 25/04A61P 25/22A61P 25/06A61P 25/28A61P 29/00A61P 25/08A61P 25/18A61P 25/14A61P 27/16A61P 25/00A61P 25/24C07D 413/14C07D 417/14A61P 19/06A61P 19/02C07D 413/12
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Claims
Abstract
The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
Claims
exact text as granted — not AI-modified1 . A compound having the formula Ia
wherein:
P is selected from the group consisting of hydrogen, C 3-7 alkyl or a 3- to 8-membered ring containing one or more atoms independently selected from C, N, O and S, which ring may optionally be fused with a 5- or 6-membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S;
R 1 is selected from the group consisting of hydrogen, hydroxy, halo, nitro, C 1-6 alkylhalo, OC 1-6 alkylhalo, C 1-6 alkyl, OC 1-6 alkyl, C 2-6 alkenyl, OC 2-6 alkenyl, C 2-6 alkynyl, OC 2-6 alkynyl, C 0-6 alkylC 3-6 cycloalkyl, OC 0-6 alkylC 3-6 cycloalkyl, C 0-6 alkylaryl, OC 0-6 alkylaryl, CHO, (CO)R 5 , O(CO)R 5 , O(CO)OR 5 , O(CN)OR 5 , C 1-6 alkylOR 5 , OC 2-6 alkylOR 5 , C 1-6 alkyl(CO)R 5 , OC 1-6 alkyl(CO)R 5 , CO 6 alkylCO 2 R 5 , OC 1-6 alkylCO 2 R 5 , C 0-6 alkylcyano, OC 2-6 alkylcyano, C 0-6 alkylNR 5 R 6 , OC 2-6 alkylNR 5 R 6 , C 1-6 alkyl(CO)NR 5 R 6 , OC 1-6 alkyl(CO)NR 5 R 6 , C 0-6 alkylNR 5 (CO)R 6 , OC 2-6 alkylNR 5 (CO)R 6 , C 0-6 alkylNR 5 (CO)NR 5 R 6 , C 0-6 alkylSR 5 m OC 2-6 alkylSR 5 , C 0-6 alkyl(SO)R 5 , OC 2-6 alkyl(SO)R 5 , C 0-6 alkylSO 2 R 5 , OC 2-6 alkylSO 5 , C 0-6 alkyl(SO 2 )NR 5 R 6 , OC 2-6 alkyl(SO 2 )NR 5 R 6 ,C 0-6 alkylNR 5 (SO 2 )R 6 , OC 2-6 alkylNr 5 (SO 2 )R 6 , C 0-6 alkylNR 5 (SO 2 )NR 5 R 6 , OC 2-6 alkylNR 5 (SO 2 )NR 5 R 6 , (CO)NR 5 R 6 , NR 5 OR 6 , C 0-6 alkylNR 5 (CO)OR 6 , OC 2-6 alkylNR 5 (CO)OR 6 , SO 3 R 5 and a 5- or 6membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S, wherein said ring may be substituted by one or more A;
M 1 is selected from the group consisting of a bond, C 1-3 alkyl, C 2-3 alkenyl, C 2-3 alkynyl, C 0-4 alkyl(CO)C 0-4 alkyl, C 0-3 alkylOC 0-3 alkyl, C 0-3 alkyl(CO)NR 5 , C 0-3 alkyl(CO)NR 5 C 0-3 alkyl, C 0-4 alkylNR 5 , C 0-3 alkylSC 0-3 alkyl, C 0-3 alkyl(SO)C 0-3 alkyl or C 0-3 alkyl(SO 2 )C 0-3 alkyl,
R 2 is selected from the group consisting of hydrogen, hydroxy, C 0-6 alkylcyano, oxo, ═NR 5 , ═NOR 5 , C 1-4 alkylhalo, halo, C 1-4 alkyl, O(CO)C 1-4 alkyl, C 1-4 alkyl(SO)C 0-4 alkyl, C 1-4 alkyl(SO 2 )C 0-4 alkyl, (SO)C 0-4 alkyl, (SO 2 )C 0-4 alkyl, OC 1-4 alkyl, C 1-4 alkylOR 5 and C 0-4 alkylNR 5 R 6 ;
X 1 , X 2 and X 3 are independently selected from the group consisting of CR, CO, N, NR, O and S;
R is selected from the group consisting of hydrogen, C 0-3 alkyl, halo, C 0-3 alkylOR 5 , C 0-3 alkylNR 5 R 6 , C 0-3 alkyl(CO)OR 5 , C 0-3 alkylNR 5 R 6 and C 0-3 alkylaryl;
M 2 is selected from a group consisting of a bond, C 1-3 alkyl, C 3-7 cycloalkyl, C 2-3 alkenyl, C 2-3 alkynyl, C 0-4 alkyl(CO)C 0-4 alkyl, C 0-3 alkylOC 0-3 alkyl, C 0-3 alkylNR 5 C 1-3 alkyl, C 0-3 alkyl(CO)NR 5 , CO 4 alkylNR 5 , C 0-3 alkylSC 0-3 alkyl, C 0-3 alkyl(SO)C 0-3 alkyl and C 0-3 alkyl(SO 2 )C 0-3 alkyl;
R 3 is selected from a group consisting of hydrogen, hydroxy, C 0-6 alkylcyano, oxo, ═NR 5 , ═NOR 5 , C 1-4 alkylhalo, halo, C 1-4 alkyl, O(CO)C 1-4 alkyl, C 1-4 alkyl(SO)CO 0-4 alkyl, C 1-4 alkyl(SO 2 )C 0-4 alkyl, (SO)C 0-4 alkyl, (SO 2 )C 0-4 alkyl, OC 1-4 alkyl, C 1-4 alkylOR 5 and C 0-4 alkylNR 5 R 6 ;
X 4 is selected from the group consisting of C 0-4 alkylR 5 , C 0-4 alkyl(NR 5 R 6 ), C 0-4 alkyl(NR 5 R 6 )═N, NR 5 C 0-4 alkyl(NR 5 R 6 )═N, NOC 0-4 alkyl, C 1-4 alkylhalo, C, O, SO, SO 2 and S;
Q is a 5- or 6-membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S, which group may optionally be fused with a 5- or 6-membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S and which fused ring may be substituted by one or more A;
R 4 is selected from the group consisting of hydrogen, hydroxy, C 0-6 alkylcyano, oxo, ═NR 5 , ═NOR 5 , C 1-4 alkylhalo, halo, C 1-4 alkyl, OC 1- alkyl, OC 0-6 alkylaryl, O(CO)C 1-4 alkyl, C 0-4 alkyl(S)CO 4 alkyl, C 1-4 alkyl(SO)C 0-4 alkyl, C 1-4 alkyl(SO 2 )C 0-4 alkyl, (SO)C 0-4 alkyl, (SO 2 )C 0-4 alkyl, C 1-4 alkylOR 5 , C 0-4 alkylNR 5 R 6 and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O or S, wherein said ring may be substituted by one or more A;
R 5 and R 6 are independently selected from the group consisting of hydrogen, hydroxy, C 1-6 alkyl, C 0-6 alkylC 3-6 cycloalkyl, C 0-6 alkylaryl, C 0-6 alkylheteroaryl and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O and S, and wherein R 5 and R 6 may together form a 5- or 6-membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S;
wherein any C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 0-6 alkylC 3-6 cycloalkyl, C 0-6 alkylaryl and C 0-6 alkylheteroaryl defined under R 1 , R 2 , R 3 , R 4 , R 5 and R 6 may be substituted by one or more A;
A is selected from the group consisting of hydrogen, hydroxy, oxo, halo, nitro, C 0-6 alkylcyano, C 1-4 alkyl, C 0-4 alkylC 3-6 cycloalkyl, C 1-6 alkylhalo, OC 1-6 alkylhalo, C 2-6 alkenyl, OC 1-6 alkyl, C 0-3 alkylaryl, C 0-6 alkylOR 5 , OC 2-6 alkylOR 5 , C 0-6 alkylSR 5 , OC 2-6 alkylSR 5 , (CO)R 5 , O(CO)R 5 , OC 2-6 alkylcyano, C 0-6 alkylCO 2 R 5 , OC 1-6 alkylCO 2 R 5 , O(CO)OR 5 , OC 1-6 alkyl(CO)R 5 , C 1-6 alkyl(CO)R 5 , NR 5 OR 6 , C 0-6 alkylNR 5 R 6 , OC 2-6 alkylNR 5 R 6 , C 0-6 alkyl(CO)NR 5 R 6 , OC 1-6 alkyl(CO)NR 5 R 6 , OC 2-6 alkylNR 5 (CO)R 6 , C 0-6 alkylSR 5 (CO)R 6 , C 0-6 alkylNR 5 (CO)NR 5 R 6 , O(CO)NR 5 R 6 , NR 5 (CO)OR 6 , C 0-6 alkyl(SO 2 )NR 5 R 6 , OC 2-6 alkyl(SO 2 )NR 5 R 6 , C 0-6 alkylNR 5 (SO 2 )R 6 , OC 2-6 alkylNR 5 (SO 2 )R 6 , SO 3 R 5 , C 1-6 alkylNR 5 (SO 2 )NR 5 R 6 , OC 2-6 alkyl(SO 2 )R 5 , C 0-6 alkyl(SO 2 )R 5 , C 0-6 alkyl)SO)R 5 , OC 2-6 alkyl(SO)R 5 and a 5- or 6-membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S;
m is selected from 0, 1, 2, 3 and 4; and
n is selected from 0, 1, 2 and 3,
or salt thereof.
2 . A compound having the formula I
wherein:
P is selected from the group consisting of thiophene, pyridyl, thiazolyl, furyl, pyrrolyl and phenyl, whereby the phenyl ring is substituted on position 3 or disubstituted on positions 2 and 5;
R 1 is attached to P via a carbon atom on ring P and is selected from the group consisting of hydrogen, hydroxy, halo, nitro, C 1-6 alkylhalo, OC 1-6 alkylhalo, C 1-6 alkyl, OC 1-6 alkyl, C 2-6 alkenyl, OC 2-6 alkenyl, C 2-6 alkynyl, OC 2-6 alkynyl, C 0-6 alkylC 3-6 cycloalkyl, OC 0-6 alkylC 3-6 cycloalkyl, C 0-6 alkylaryl, OC 0-6 alkylaryl, CHO, (CO)R 5 , O(CO)R 5 , O(CO)OR 5 , O(CN)OR 5 , C 1-6 alkylOR 5 , OC 2-6 alkylOR 5 , C 1-6 alkyl(CO)R 5 , OC 1-6 alkyl(CO)R 5 , C 0-6 alkylCO 2 R 5 , OC 1-6 alkylCO 2 R 5 , C 0-6 alkylcyano, OC 2-6 alkylcyano, C 0-6 alkylNR 5 R 6 , OC 2-6 alkylNR 5 R 6 , C 1-6 alkyl(CO)NR 5 R 6 , OC 1-6 alkyl(CO)NR 5 R 6 , C 0-6 alkylNR 5 (CO)R 6 , OC 2-6 alkylNR 5 (CO)R 6 , C 0-6 alkylNR 5 (CO)NR 5 R 6 , C 0-6 alkylSR 5 , OC 2-6 alkylSR 5 , C 0-6 alkyl(SO)R 5 , OC 2-6 alkyl(SO)R 5 , C 0-6 alkylSO 2 R 5 , OC 2-6 alkylSO 2 R 5 , C 0-6 alkyl(SO 2 )NR 5 R 6 , OC 2-6 alkyl(SO 2 )NR 5 R 6 ,C 0-6 alkylNR 5 (SO 2 )R 6 , OC 2-6 alkylNR 5 (SO 2 )R 6 , C 0-6 alkylNR 5 (SO 2 )NR 5 R 6 , OC 2-6 alkylNR 5 (SO 2 )NR 5 R 6 , (CO)NR 5 R 6 , O(CO)NR 5 R 6 , NR 5 OR 6 , C 0-6 alkylNR 5 (CO)OR 6 , OC 2-6 alkylNR 5 (CO)OR 6 , SO 3 R 5 and a 5- or 6-membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S;
M 1 is a bond;
X 1 selected from the group consisting of C, CO, N, O and S;
X 2 is selected from the group consisting of C, N, O and S;
X 3 is i) selected from the group consisting of N, O and S; or
ii) selected from N, O, S, and C when X 2 is selected from N, O, or S, and when X 3 is C the substituent R on X 3 is H.;
R is selected from the group consisting of hydrogen, C 0-3 alkyl, halo, C 0-3 alkylOR 5 , C 0-3 alkylNR 5 R 6 , C 0-3 alkyl(CO)OR 5 and C 0-3 alkylaryl;
M 2 is selected from a group consisting of a bond, C 1-3 alkyl, C 2-3 alkynyl, C 0-4 alkyl(CO)C 0-4 alkyl, C 0-3 alkylOC 0-3 alkyl, C 0-3 alkylNR 5 C 1-3 alkyl, C 0-3 alkyl(CO)NR 5 , C 0-4 alkylNR 5 , C 0-3 alkyl(SO)C 0-3 alkyl and C 0-3 alkyl(SO 2 )C 0-3 alkyl;
R 3 is selected from a group consisting of hydroxy, C 0-6 alkylcyano, oxo, ═NR 5 , ═NOR 5 , C 1-4 alkylhalo, halo, C 1-4 alkyl, O(CO)C 1-4 alkyl, C 1-4 alkyl(SO)C 0-4 alkyl, C 1-4 alkyl(SO 2 )C 0-4 alkyl, (SO)C 0-4 alkyl, (SO 2 )C 0-4 alkyl, OC 1-4 alkyl, C 1-4 alkylOR 5 and C 0-4 alkylNR 5 R 6 ;
X 4 is selected from the group consisting of C 0-4 alkylR 5 R 6 , C 3-7 cycloalkyl, C 1-4 alkyl(NR 5 R 6 ), NR 5 , C 0-4 alkyl(NR 5 R 6 )═N, NR 5 C 0-4 alkyl(NR 5 R 6 )═N, NOC 0-4 alkyl, C 1-4 alkylhalo, O, SO, SO 2 and S, and wherein the bond between M 2 and X 4 is a single bond;
Q is i) selected from the group consisting of triazolyl, imidazolyl, oxadiazolyl, imidazolonyl, oxazolonyl, thiazolonyl, tetrazolyl and thiadiazolyl, and wherein any substitutable nitrogen atom in the ring is substituted with R 4 on such nitrogen atom and any suitable carbon atom is optionally substituted with R 4 ; and
R 4 is selected from the group consisting of C 0-6 alkylcyano, ═NC, 4 alkyl, ═NOR 5 , C 1-4 alkylhalo, halo, C 1-6 alkyl, OC 1-4 alkyl, C 2-4 alkenyl, C 0-2 alkylC 3-6 cycloalkyl, C 0-6 alkylaryl, C 0-6 alkylheteroaryl, OC 0-6 alkylaryl, OC 0-6 alkylheteroaryl, NC 0-6 alkylaryl, NC 0-6 alkylheteroaryl,C 0-6 alkylOaryl, C 0-6 alkylOheteroaryl, C 0-6 alkylNaryl, C 0-6 alkylNheteroaryl, OC 0-6 alkylOaryl, OC 0-6 alkylOheteroaryl, OC 0-6 alkylNaryl, OC 0-6 alkylNheteroaryl, NC 0-6 alkylOaryl, NC 0-6 alkylOheteroaryl, NC 0-6 alkylNaryl, NC 0-6 alkylNheteroaryl, O(CO)C 1-4 alkyl, C 0-4 alkyl(CO)OC 1-4 alkyl, C 1-4 alkyl(S)C 0-4 alkyl, C 1-4 alkyl(SO)C 0-4 alkyl, C 1-4 alkyl(SO 2 )C 0-4 alkyl, (SO)C 0-4 alkyl, (SO 2 )C 0-4 alkyl, C 1-4 alkylOR 5 , C 0-4 alkylN(C 1-4 alkyl) 2 and a 3- or 6-membered non-aromatic ring containing one or more atoms independently selected from C, N, O and S, which ring may optionally be fused with a 5-membered ring containing one or more atoms independently selected from the group consisting of C, N and O and wherein said ring and said fused ring may be substituted by one or two A; or
ii) selected from the group consisting of benzoimidazolyl, benzooxazolyl, tetrahydrotriazolopyridyl, tetrahydrotriazolopyrimidinyl, pyridonyl, pyridazinyl, imidazopyridyl, oxazolopyridyl, thiazolopyridyl, imidazopyridazinyl, oxazolopyridazinyl, thiazolopyridazinyl and purinyl; and
R 4 is selected from the group consisting of hydrogen, hydroxy, C 0-6 alkylcyano, ═NR 5 , ═NOR 5 , C 1-4 alkylhalo, halo, C 1-6 alkyl, OC 1-4 alkyl, OC 0-6 alkylaryl, O(CO)C 1-4 alkyl, C 0-4 alkyl(S)C 0-4 alkyl, C 1-4 alkyl(SO)C 0-4 alkyl, C 1-4 alkyl(SO 2 )C 0-4 alkyl, (SO)C 0-4 alkyl, (SO 2 )C 0-4 alkyl, C 1-4 alkylOR 5 , C 0-4 alkylNR 5 R 6 and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O and S, which ring may optionally be fused with a 5- or 6-membered ring containing one or more atoms independently selected from the group consisting of C, N and O and wherein said ring and said fused ring may be substituted by one or two A;
R 5 and R 6 are independently selected from the group consisting of hydrogen and C 1-6 alkyl; wherein any C 1-6 alkyl defined under R 1 , R 2 and R 4 may be substituted by one or more A;
A is selected from the group consisting of hydrogen, hydroxy, halo, nitro, oxo, C 0-6 alkylcyano, C 0-4 alkylC 3-6 cycloalkyl, C 1-6 alkyl, C 1-6 alkylhalo, OC 0-6 alkylhalo, C 2-6 alkenyl, C 0-3 alkylaryl, C 0-6 alkylOR 5 , OC 2-6 alkylOR 5 , C 1-6 alkylSR 5 , OC 2-6 alkylSR 5 , (CO)R 5 , O(CO)R 5 , OC 2-6 alkylcyano, OC 1-6 alkylCO 2 R 5 , O(CO)OR 5 , OC 1-6 alkyl(CO)R 5 , C 1-6 alkyl(CO)R 5 , NR 5 OR 6 , OC 2-6 alkylNR 5 R 6 , C 0-6 alkyl(CO)NR 5 R 6 , OC 1-6 alkyl(CO)NR 5 R 6 , OC 2-6 alkylNR 5 (CO)R 6 , C 0-6 alkylNR 5 (CO)R 6 , C 0-6 alkylNR 5 (CO)NR 5 R 6 , O(CO)NR 5 R 6 , C 0-6 alkyl(SO 2 )NR 5 R 6 , OC 2-6 alkyl(SO 2 )NR 5 R 6 , C 0-6 alkylNR 5 (SO 2 )R 6 , OC 2-6 alkylNR 5 (SO 2 )R 6 , SO 3 R 5 , C 1-6 alkylNR 5 (SO 2 )NR 5 R 6 , OC 2-6 alkyl(SO 2 )R 5 , C 0-6 alkyl(SO 2 )R 5 , C 0-6 alkyl(SO)R 5 , OC 2-6 alkyl(SO)R 5 and a 5-membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S;
m1 is selected from 0, 1, 2, 3 and 4;
m2 is selected from 0, 1, 2 and 3;
n is selected from 0, 1 and 2; and
t is 0 or 1,
and salts thereof,
with the proviso that the compound is not 5-(4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-thiophen-3-yl-[1,2,4]oxadiazole, 1,2-di{2-(3-amino-phenyl)-[1,3,4]oxadiazole-yl)ethane, 1,2-di{5-[5-(4-nitro-phenyl)furan-2-yl]-[1,3,4]oxadiazol-yl)ethane, 1,2-di{5-[5-(4-bromo-phenyl)furan-2-yl]-[1,3,4]oxadiazol-yl)ethane, 1,2-di{5-[5-(4-chloro-phenyl)furan-2-yl]-[1,3,4]oxadiazol-yl)ethane and 1,2-di{5-[5-(2,4-dibromo-phenyl)furan-2-yl]-[1,3,4]oxadiazol-yl)ethane.
3 . A compound according to claim 2 , wherein P is selected from the group consisting of thiophene, pyridyl, thiazolyl, furyl, pyrrolyl or phenyl, whereby the phenyl ring is substituted on position 3 or disubstituted on positions 2 and 5 and R 1 is selected from the group consisting of hydrogen, hydroxy, halo, nitro, C 1-6 alkylhalo, OC 1-6 alkylhalo, C 1-6 alkyl, OC 0-6 alkyl, C 2-6 alkenyl, C 0-6 alkylC 3-6 cycloalkyl, C 0-6 alkylOR 5 , C 1-6 alkyl(CO)R 5 , C 0-6 alkylCO 2 R 5 , C 0-6 alkylcyano, C 0-6 alkylNR 5 R 6 , C 0-6 alkylSR 5 and a 5-membered ring containing one or more atoms independently selected from the group consisting of C and O.
4 . A compound according to claim 3 , wherein P is phenyl substituted on position 3 or disubstituted on positions 2 and 5.
5 . A compound according to claim 2 , wherein X 1 is N and one of X 2 and X 3 is O and the other is N.
6 . A compound according to claim 2 , wherein the ring containing X 1 , X 2 and X 3 forms an oxadiazole, isoxazole, oxazole, chloro-isoxazole or a methyl-isoxazole.
7 . A compound according to claim 2 , wherein M 2 is a bond or C 1-3 alkyl and R 3 is hydrogen, methyl or dimethyl.
8 . A compound according to claim 2 , wherein X 4 is selected from the group consisting of C 0-4 alkylR 5 R 6 , C 3-7 cycloalkyl, NR 5 , O, SO, SO 2 and S and R 5 and R 6 are independently selected from hydrogen and C 1-6 alkyl.
9 . A compound according to claim 8 , wherein X 4 is selected from the group consisting of CH 2 , CHCH 3 , CH(CH 3 ) 2 and NR 5 .
10 . A compound according to claim 8 , wherein X 4 is S.
11 . A compound according to claim 2 , wherein Q is selected from the group consisting of triazolyl, imidazolyl, oxadiazolyl, imidazolonyl, oxazolonyl, thiazolonyl, tetrazolyl and thiadiazolyl, and wherein any substitutable nitrogen atom in the ring is substituted with R 4 on such nitrogen atom, and any suitable carbon atom is optionally substituted with R 4 and R 4 is selected from the group consisting of C 1-4 alkylhalo, C 1-6 alkyl, C 2-4 alkenyl, C 0-2 alkylC 3-6 cycloalkyl, C 0-6 alkylaryl, C 0-6 alkylheteroaryl, OC 0-6 alkylaryl, OC 0-6 alkylheteroaryl, NC 0-6 alkylaryl, NC 0-6 alkylheteroaryl,C 0-6 alkylOaryl, C 0-6 alkylOheteroaryl, C 0-6 alkylNaryl, C 0-6 alkylNheteroaryl, OC 0-6 alkylOaryl, OC 0-6 alkylOheteroaryl, OC 0-6 alkylNaryl, OC 0-6 alkylNheteroaryl, NC 0-6 alkylOaryl, NC 0-6 alkylOheteroaryl, NC 0-6 alkylNaryl, NC 0-6 alkylNheteroaryl, C 0-4 alkyl(CO)OC 1-4 alkyl, C 1-4 alkyl(S)C 0-4 alkyl, C 1-4 alkylOR 5 and a 3- or 6-membered non-aromatic ring containing one or more atoms independently selected from C, N, O and S, which ring may optionally be fused with a 5-membered ring containing one or more atoms independently selected from the group consisting of C, N and O and wherein said ring and said fused ring may be substituted by one or two A.
12 . A compound according to any one of claims 2 or 11 , wherein Q is selected from the group consisting of triazolyl and thiadiazolyl.
13 . A compound according to claim 2 , wherein Q is selected from the group consisting of benzoimidazolyl, benzooxazolyl, tetrahydrotriazolopyridyl, tetrahydrotriazolopyrimidinyl, pyridonyl, pyridazinyl, imidazopyridyl, oxazolopyridyl, thiazolopyridyl, imidazopyridazinyl, oxazolopyridazinyl, thiazolopyridazinyl and purinyl and R 4 is hydrogen or C 1-6 alkyl.
14 . A compound according to any one of claims 2 or 13 , wherein Q is selected from the group consisting of pyridonyl, tetrahydrotriazolopyridyl and tetrahydrotriazolopyrimidinyl.
15 . A compound according to claim 2 , wherein R 4 is selected from the group consisting of benzo[b]thiophenyl, benzodioxolyl, bromo, bromofuryl, butoxyphenyl, chloromethoxypyridyl, chlorophenyl, chlorophenylmethanol, chloropyridyl, chlorothiophene, cyanophenyl, cyclohexyl, cyclopentyl, dichloro-phenyl, dichloropyridyl, difluorophenyl, dimethylthiazolyl, ethanol, ethoxymethyl, fluoromethylphenyl, fluorophenyl, formic acid methyl ester, furyl, hydrogen, hydroxyphenoxymethyl, hydroxyphenyl, imidazolyl, methoxyethyl, methoxymethyl, methoxyphenoxymethyl, methoxyphenyl, methoxyphenylethyl, methoxypyridazinyl, methoxypyridyl, methoxypyrimidinyl, methoxythiophene, methylimidazolyl, methylpyridyl, methylsulfanylmethyl, methylthiazolyl, methylthiophene, nitrofuryl, nitrophenyl, phenyl, p-tolyloxymethyl, pyridazinyl, pyridine-oxidyl, benzylmorpholinyl, pyridinolyl, pyridyl, pyridylmethyl, pyrimidinyl, tert-butylphenyl, tetrahydrofuiryl, thiazolyl, thiophene, tolyl, trifluoromethyl, acetic acid methylester, allyl, amino, benzyl, cyclopropylmethyl, ethyl, fluorobenzyl, fluoroethyl, furylmethyl, hydroxyethyl, isobutyl, methyl, methylbenzyl, methylbutyl, methylsulfanylpropyl, n-butyl, n-hexyl, n-propyl, tetrahydrofurylmethyl, thiophenylmethyl and trifluoroethyl.
16 . A compound which is selected from the group consisting of
2-[5-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-1H-benzoimidazole, 5-(3-Methoxy-phenyl)-3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-[5-(1-Methyl-5-thiophen-2-yl-1H-imidazol-2-ylsulfanylmethyl)-[1,2,4]oxadiazol-3-yl]-benzonitrile, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]traiazol-3-ylsulfanylmethyl)-5-phenyl-[1,2,4]oxadiazole, 2-[5-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-5-methyl-1H-benzoimidazole, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-trifluoromethyl-phenyl)-[1,2,4]oxadiazole, 3-(3-Methoxy-phenyl)-5-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl-[1,2,4]oxadiazole, 5-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazole, 5-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-m-tolyl-[1,2,4]oxadiazole, 3-[3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzonitrile, 3-[4-Methyl-5-(2-methyl-thiazol-4-yl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-5-m-tolyl-[1,2,4]oxadiazole, 3-[5-(2-Methyl-thiazol-4-yl)-[1,3,4]oxadiazol-2-ylsulfanylmethyl]-5-m-tolyl-[1,2,4]oxadiazole, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-2-yl-[1,2,4]oxadiazole, 3-[5-(2,4-Dimethyl-thiazol-5-yl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-5-m-tolyl-[1,2,4]oxadiazole, 3-[4-Methyl-5-(5-nitro-furan-2-yl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-5-m-tolyl-[1,2,4]oxadiazole, 4-[4-Methyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl-]-pyridine, 3-[5-(4-tert-Butyl-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-5-m-tolyl-[1,2,4]-oxadiazole, 2-Chloro-5-[4-methyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]trazol-3-yl]-pyridine, 2-[5-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-benzooxazole, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-3-yl-[1,2,4]oxadiazole, 3-(5-Furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 5-(3-Fluoro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 2-(5-m-Tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-pyridine, 2-[5-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-1H-imidazo[4,5-b]pyridine, 5-(3-Fluoro-5-methyl-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-Methyl-5-[3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 3-(4-Methyl-5-phenyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 2-[4-Methyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl-]-pyridine, 4-Benzyl-2-[4-methyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl-]-morpholine, 4-[4-Methyl-5-(5-thiophen-3-yl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]trazol-3-yl]-pyridine, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiazol-4-yl-[1,2,4]oxadiazole, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-nitro-phenyl)-[1,2,4]oxadiazole, 2-Methyl-4-[3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 3-[4-Methyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl-]-pyridine, 3-(4-Methyl-5-thiophene-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 3-(4-Methyl-5-thiazol-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 5-(3-Iodo-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Ethyl-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 2-[5-(2-Methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-1H-benzoimidazole, 2-[5-(3-Iodo-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-1H-benzoimidazole, 3-(4-Methyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 2,6-Dichloro-4-[4-methyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 3-(4-Methyl-5-p-tolyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, Dimethyl-{3-[3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]phenyl}-amine, 5-(3-Chloro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[[1,2,4]oxadiazole, b 3 -(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-trifluoromethoxy-phenyl)[1,2,4]oxadiazole, 3-(5-Cyclohexyl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 3-(5-tert-Butyl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 5-(3-Bromo-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 2-[5-(3-Bromo-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-1H-benzoimidazole, 5-(3-Methoxymethyl-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-lsulfanylmethyl)-[1,2,4]oxadiazole, 2-[5-(3-Methoxymethyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-1H-benzoimidazole, 4-[5-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-3-yl]-pyridine, 2-{1-[5-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-3-yl-ethylsulfanyl}-1-methyl-1H-imidazo[4,5-b]pyridine, 2-[5-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-1-methyl-1H-imidazo[4,5-b], 3-[1-Methyl-1-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-5-m-tolyl-[1,2,4]oxadiazole, 3-[1-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-5-m-tolyl-[1,2,4]oxadiazole, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazole-3-sulfonylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazole-3-sulfinylmethyl)-5-m-tolyl-[1,2,4]oxadiazole and 5-(3-Furan-3-yl-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole or salt thereof.
17 . A compound which is selected from the group consisting of
4-(4-Cyclopropyl-5-{1-[5-(2,5-difluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-{4-Methyl-5-[1-(5-m-tolyl-[1,2,4]oxadiazol-3-yl)-ethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-o-tolyl-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-cyclopropyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 2-{3-[5-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-5-thiophen-2-yl-[1,2,4]triazol-4-yl}-ethanol, 4-{4-Ethyl-5-[5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyrimidine, 3-(4-Ethyl-5-furan-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazole, {3-[5-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-5-thiophen-2-yl-[1,2,4]triazol-4-yl}-acetic acid methyl ester, 5-(2-Fluoro-5-methyl-phenyl)-3-[5-furan-2-yl-4-(2-methoxy-ethyl)-4H-[1,2,4]traizol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-(4-Cyclopropyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazole, 3-(5-Chloro-2-fluoro-phenyl)-5-(4-cyclopropylmethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[3-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyrimidine, 3-(5-Cyclopentyl-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-{4-ethyl-5-[2-(4-methoxy-phenyl)-ethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-ethyl-5-p-tolyloxymethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-(2-methoxy-ethyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-(5-Chloro-2-fluoro-phenyl)-5-(4-ethyl-5-methoxymethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(5-Chloro-2-fluoro-phenyl)-3-(4-ethyl-5-methoxymethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-ethyl-5-methoxymethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-(4-ethyl-5-methoxymethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-(5-{1-[3-(3-Chloro-phenyl)-isoxazol-5-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 3-(4-Allyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-chloro-pheny)-[1,2,4]oxadiazole, 3-(4-Allyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-3-yl-[1,2,4]oxadiazole, 5-(4-Allyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-furan-2-yl-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(4-methoxy-phenoxymethyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-[4-ethyl-5-(4-methoxy-phenoxymethyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, {5-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-methanol, 3-(3-Chloro-phenyl)-5-[4-ethyl-5-(2-methoxy-ethyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-(4-ethyl-5-methylsulfanylmethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-(5-ethoxymethyl-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazole-3-carboxylic acid methyl ester, 2-(5-Chloro-2-fluoro-phenyl)-5-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazole, 2-(3-Chloro-phenyl)-5-(4-cyclopropyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazole, 5-(3-Chloro-phenyl)-3-{1-[4-ethyl-5-(tetrahydro-faran-2-yl)-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,2,4]oxadiazole, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridazine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-ylmethyl)-pyridine, 5-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridin-2-ol, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-phenol, 5-(3-Chloro-phenyl)-3-[5-(4-methoxy-phenoxymethyl)-4-(tetrahydro-furan-2-ylmethyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-cyclopropyl-5-(4-methoxy-phenoxymethyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(5-Chloro-2-fluoro-phenyl)-3-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(4-Ethyl-5-methoxymethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 3-[4-Ethyl-5-(tetrahydro-furan-2-yl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-5-m-tolyl-[1,2,4]oxadiazole, 2-(3-Chloro-phenyl)-5-{1-[4-ethyl-5-(4-methoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,3,4]oxadiazole, 4-{5-[3-(2,5-Difluoro-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyrimidine, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyrimidine, 3-(3-Chloro-phenyl)-5-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethly)-[1,2,4]oxadiazole, 5-(3-Methylsulfanyl-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 2-[5-(3-Methylsulfanyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-1H-benzoimidazole, 5-(2,5-Dimethyl-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(2-Fluoro-5-methyl-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Cyclopropyl-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[2-(3-Chloro-phenyl)-oxazol-4-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-[4-Methyl-5-(5-thiophen-2-yl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]traizol-3-yl]-pyridine, 4-{4-Methyl-5-[5-(3-methylsulfanyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 2-Methyl-4-[3-(4-methyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 1-{3-[3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-phenyl}-ethanone, 4-{5-[5-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 2-Methyl-4-[4-methyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 3-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazole, 4-{5-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-(4-Butyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-chloro-phenyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-(3-methoxy-propyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-(4-Benzyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-chloro-phenyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-furan-2-ylmethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(3-Chloro-phenyl)-3-(4-methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-2-methyl-pyridine, 5-(5-Chloro-2-fluoro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-{5-[5-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(3-Chloro-phenyl)-3-(5-thiophen-2-yl-4-thiophen-2-ylmethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-{5-[3-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[3-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[5-(5-Bromo-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-{5-[5-(5-Bromo-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(5-Bromo-2-fluoro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(4-Methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazole, 3-{5-[5-(3-Fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[5-(3-Fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(3-Fluoro-phenyl)-3-(4-methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanymethyl)-[1,2,4]oxadiazole, 3-[4-Methyl-5-(5-thiophen-3-yl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]traizol-3-yl]-pyridine, 3-(4-Methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-3-yl-[1,2,4]oxadiazole, 2-Chloro-4-[3-(4-methyl-5-pyridin-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 2-Chloro-4-[3-(4-methyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 2-Chloro-4-[3-(4-methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 4-[4-Methyl-5-(5-phenyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 3-(4-Methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-phenyl-[1,2,4]oxadiazole, 5-(5-Bromo-2-fluoro-phenyl)-3-(4-methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazole, 2-Chloro-4-[3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 4-{5-[3-(3-Fluoro-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-(3-Fluoro-phenyl)-5-(4-methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-furan-2-ylmethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(3-Chloro-phenyl)-3-(4-ethyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-furan-2-ylmethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-(4-Furan-2-ylmethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 5-(5-Fluoro-2-methyl-phenyl)-3-(4-furan-2-ylmethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-furan-2-ylmethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-[3-(4-Methyl-5-pyridin-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzonitrile, 3-[3-(4-Methyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzonitrile, 3-[3-(4-Methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzonitrile, 5-(5-Chloro-2-fluoro-phenyl)-3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 2-Chloro-4-[3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-3-yl-[1,2,4]oxadiazole, 3-(4-Ethyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 4-[4-Ethyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 3-[4-Ethyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 3-(4-Ethyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazole, 4-{4-Ethyl-5-[5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 3-{4-Ethyl-5-[5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-5-pyridin-4-yl-[1,2,4]triazol-4-ylamine, 4-{5-[5-(5-Bromo-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-[4H-[1,2,4]triazol-3-yl}-pyridine, 5-(4-Methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-thiophen-2-yl-[1,2,4]oxadiazole, 3-[3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzonitrile, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-phenyl-[1,2,4]oxadiazole, 4-[3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-2-methoxy-pyridine, 3-(3-Chloro-phenyl)-5-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 2-Methyl-4-[3-(4-methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 4-[3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-pyridine, 5-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-thiophen-2-yl-[1,2,4]oxadiazole, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-[3-(4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-pyridine, 3-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-benzonitrile, 5-(3-Chloro-phenyl)-3-[5-(3-chloro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[5-(4-chloro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 4-{5-[5-(2,5-Dichloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(2,5-Dichloro-phenyl)-3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(2,5-Difluoro-phenyl)-3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[5-(2,5-Difluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(2,5-Dichloro-phenyl)-3-(4-ethyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(2,5-Difluoro-phenyl)-3-(4-ethyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-propyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[5-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-propyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-2-[1,2,4]oxadiazole, 3-(4-Methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-2-yl-[1,2,4]oxadiazole, 4-[4-Methyl-5-(3-thiophen-3-yl-[1,2,4]oxadiazol-5-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 5-(4-Methyl-5-thiophen-3-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-thiophen-3-yl-[1,2,4]oxadiazole, 5-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-thiophen-3-yl-[1,2,4]oxadiazole, 5-[3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-thiophene-3-carbonitrile, 5-(3-Chloro-phenyl)-3-[5-(2-fluoro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[5-(3-fluoro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[5-(4-fluoro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-(5-Benzo[b]thiophen-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-chloro-phenyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[5-(3-methoxy-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[5-(4-methoxy-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazole, 3-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,2,4]oxadiazole, 3-(4-Ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazole, 3-[5-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-5-pyridin-4-yl-[1,2,4]triazol-4-ylamine, 3-[5-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-5-thiophen-2-yl-[1,2,4]triazol-4-ylamine, 3-Pyridin-4-yl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-[1,2,4]triazol-4-ylamine, 3-Thiophen-2-yl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-[1,2,4]triazol-4-ylamine, 3-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-3-yl-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-[3-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-pyridine, 5-(2,5-Difluoro-phenyl)-3-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-[4-Ethyl-5-(5-thiophen-3-yl-isoxazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 4-Ethyl-3-furan-2-yl-5-(5-thiophen-3-yl-isoxazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazole, 5-(3-Chloro-phenyl)-3-[5-(3,5-dichloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-ethyl-5-p-tolyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-ethyl-5-m-tolyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(3-nitro-phenyl)-4H-[1,2,4]triazol-3-ylsulfanylmethy]-[1,2,4]oxadiazole, 4-{5-[3-(3-Chloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(3-Chloro-phenyl)-3-[5-(2,5-difluoro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[5-(3-chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[5-(4-chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-oxazol-2-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[5-(3-Chloro-phenyl)-oxazol-2-ylmethylsulfanyl]-4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazole, 3-[5-(3-Chloro-phenyl)-oxazol-2-ylmethylsulfanyl]-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 5-(2-Chloro-5-methyl-phenyl)-3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[3-(3-Chloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazole-3-yl}-pyridine, 3-[3-(3-Chloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazole, 3-[3-(3-Chloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 4-{5-[5-(2-Fluoro-5-methyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(2,5-Dichloro-thiophen-3-yl)-3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[5-(2,5-Dichloro-thiophen-3-yl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{4-Ethyl-5-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 4-Ethyl-3-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-5-thiophen-2-yl-4H-[1,2,4]triazole, 4-Ethyl-3-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-5-furan-2-yl-4H-[1,2,4]triazole, 5-(3-Chloro-phenyl)-3-(4-ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-(4-ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(4-Ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-3-yl-[1,2,4]oxadiazole, 5-(4-Ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-thiophen-3-yl-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(3-fluoro-phenyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(4-fluoro-phenyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-(4-Ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-thiophen-2-yl-[1,2,4]oxadiazole, 3-{3-[5-(3-Chloro-thiophen-2-yl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethly]-[1,2,4]oxadiazol-5-yl}-benzonitrile, 4-{5-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 2-(3-Chloro-phenyl)-5-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(4-methoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[5-(2-fluoro-5-methyl-phenyl)-4-furan-2-ylmethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 4-[3-(4-Ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-pyridine, 3-(4-Ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-methoxy-phenyl)-[1,2,4]oxadiazole, 5-(4-Ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(3-methoxy-phenyl)-[1,2,4]oxadiazole, 5-(4-Ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-thiophen-2-yl-[1,2,4]oxadiazole, 5-(5-Chloro-2-fluoro-phenyl)-3-(4-ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-[3-(4-Ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzonitrile, 3-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-trifluoromethyl-4H-[1,2,4]triazole, 3-[5-(3-Chloro-phenyl)-oxazol-2-ylmethylsulfanyl]-4-ethyl-5-trifluoromethyl-4H-[1,2,4]triazole, 4-Ethyl-3-(5-thiophen-3-yl-isoxazol-3-ylmethylsulfanyl)-5-trifluoromethyl-4H-[1,2,4]triazole, 4-{3-[5-(3-Fluoro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazol-5-yl}-2-methyl-pyridine, 4-{3-[5-(3-Chloro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazol-5-yl}-2-methyl-pyridine, 4-{3-[5-(4-Chloro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazol-5-yl}-2-methyl-pyridine, 4-{3-[5-(4-Methoxy-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazol-5-yl}-2-methyl-pyridine, 4-[3-(4-Ethyl-5-p-tolyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-pyridine, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-fluoro-phenyl)-[1,2,4]oxadiazole, 4-{4-Ethyl-5-[5-(3-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(3-Chloro-phenyl)-3-[5-(3,5-difluoro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[5-(2,6-difluoro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 2-[3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-4-methyl-phenol, 3-{1-[5-(3-Chloro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 4-(5-{1-[5-(3-Chloro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine, 3-[5-(4-Butoxy-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-5-(3-chloro-phenyl)-[1,2,4]oxadiazole, 3-(5-Benzo[1,3]dioxol-5-yl-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-chloro-phenyl)-[1,2,4]oxadiazole, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(2-methyl-thiazol-4-yl)-[1,2,4]oxadiazole, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(4-fluoro-phenyl)-[1,2,4]oxadiazole, 4-Ethyl-3-{1-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-5-furan-2-yl-4H-[1,2,4]triazole, 4-(4-Ethyl-5-{1-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(3-methyl-3H-imidazol-4-yl)-4H-[1,2,4]traizol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(1-methyl-1H-imidazol-2-yl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(1-methyl-1H-imidazol-4-yl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-4-methyl-isoxazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[5-(3-Chloro-phenyl)-4-methyl-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(4-methyl-thiophen-2-yl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(3-methyl-thiophen-2-yl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(5-methyl-thiophen-2-yl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 4-{5-[4-Chloro-5-(3-chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[4-Chloro-5-(3-chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 2-Chloro-4-{5-[5-(3-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl]-4H-[1,2,4]triazol-3-yl}-6-methyl-pyridine, 3-[5-(5-Bromo-furan-2-yl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-5-(3-chloro-phenyl)-[1,2,4]oxadiazole, 2-Chloro-4-{5-[5-(3-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 2-Chloro-4-{5-[5-(3-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-6-methoxy-pyridine, 2-[3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-4-methyl-benzonitrile, 5-(3-Chloro-phenyl)-3-[4-ethyl-5-(3-methoxy-thiophen-2-yl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-[5-(5-Chloro-thiophen-3-yl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 3-[3-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-5-fluoro-benzonitrile, 4-Ethyl-3-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-5-thiophen-2-yl-4H-[1,2,4]triazole, 4-Methyl-3-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-5-thiophen-3-yl-4H-[1,2,4]triazole, 4-Ethyl-3-furan-2-yl-5-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazole, 4-[4-Ethyl-5-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 4-[4-Methyl-5-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 2-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-m-tolyl-[1,3,4]oxadiazole, 4-[4-Methyl-5-(5-m-tolyl-[1,3,4]oxadiazol-2-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 4-[4-Ethyl-5-(5-m-tolyl-[1,3,4]oxadiazol-2-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 4-{5-[5-(5-Chloro-thiophen-3-yl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[3-(4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-4-fluoro-benzonitrile, 3-[3-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5yl]-4-fluoro-benzonitrile, 3-[3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-4-fluoro-benzonitrile, 3-[3-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzonitrile, 3-[5-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-3-yl]-benzonitrile, 3-[3-(4-Methyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzonitrile, 5-(5-Chloro-2-fluoro-phenyl)-3-(4-methyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 2-Chloro-4-[3-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 2-Chloro-4-[3-(5-furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 2-(3-Chloro-phenyl)-5-[4-methyl-5-(2-methyl-thiazol-4-yl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,3,4]oxadiazole, 2-(3-Chloro-phenyl)-5-(4-methyl-5-thiazol-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazole, 2-(3-Chloro-phenyl)-5-(5-furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazole, 2-(3-Chloro-phenyl)-5-(4-ethyl-5-trifluoromethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazole, 4-{4-Ethyl-5-[5-(4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 3-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(4-methyl-thiophen-2-yl)-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{4-Ethyl-5-[5-(3-nitro-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 2-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-nitro-phenyl)-[1,3,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-(4-methoxy-phenyl)-4H-[1,2,4]triazole, 5-(3-Chloro-phenyl)-3-[1-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[1-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,2,4]oxadiazole, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine, 3-[5-(4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl-]-benzonitrile, 3-[5-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-benzonitrile, 3-[5-(4-Methyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-benzonitrile, 3-[5-(4-Cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-benzonitrile, 4-{5-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 2-(5-Chloro-2-fluoro-phenyl)-5-[4-ethyl-5-(4-methoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,3,4]oxadiazole, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 2-(3-Chloro-phenyl)-5-[4-ethyl-5-(4-methoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,3,4]oxadiazole, 2-(3-Chloro-phenyl)-5-[1-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,3,4]oxadiazole, 5-(5-Chloro-2-fluoro-phenyl)-3-[1-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,2,4]oxadiazole, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine, 2-Chloro-4-[3-(4-cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 4-{5-[5-(2-Fluoro-5-methyl-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{4-Ethyl-5-[5-(2-fluoro-5-methyl-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{4-Cyclopropyl-5-[5-(2-fluoro-5-methyl-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 2-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(2-fluoro-5-methyl-phenyl)-[1,3,4]oxadiazole, 2-[4-Ethyl-5-(4-methoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-5-(2-flouro-5-methyl-phenyl)-[1,3,4]oxadiazole, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 3-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 3-{1-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-ethyl-5-furan-2-yl4H-[1,2,4]triazole, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 5-(5-Chloro-2-fluoro-phenyl)-3-(5-furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(5-Chloro-2-fluoro-phenyl)-3-(5-furan-3-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-Chloro-2-[3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-phenol, 2-Chloro-4-[5-(4-methyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-pyridine, 2-Chloro-4-[5-(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-pyridine, 2-Chloro-4-[5-(4-cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-pyridine, 2-Chloro-4-[5-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-pyridine, 2-Chloro-4-{5-[4-ethyl-5-(4-methoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,3,4]oxadiazol-2-yl}-pyridine, 2-(3-Chloro-phenyl)-5-{1-[5-(4-methoxy-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,3,4]oxadiazole, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 5-(5-Bromo-2-fluoro-phenyl)-3-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 2-(3-Chloro-phenyl)-5-[5-(4-methoxy-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,3,4]oxadiazole, 4-{5-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-(5-{1-[5-(2-Fluoro-5-methyl-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(4-Ethyl-5-{1-[5-(2-fluoro-5-methyl-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(4-Cyclopropyl-5-{1-[5-(2-fluoro-5-methyl-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(4-Cyclopropylmethyl-5-{1-[5-(2-fluoro-5-methyl-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 2-(2-Fluoro-5-methyl-phenyl)-5-{1-[4-methyl-5-(2-methyl-thiazol-4-yl)-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,3,4]oxadiazole, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 2-(5-Chloro-2-fluoro-phenyl)-5-[1-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,3,4]oxadiazole, 2-(5-Chloro-2-fluoro-phenyl)-5-{1-[4-methyl-5-(2-methyl-thiazol-4-yl)-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,3,4]oxadiazole, 4-(4-Cyclopropylmethyl-5-{1-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(3-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(4-Cyclopropyl-5-{1-[5-(3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(4-Methoxy-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,3,4]oxadiazol-2-yl)-2-methyl-pyridine, 4-(5-{1-[4-Ethyl-5-(4-methoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,3,4]oxadiazol-2-yl)-2-methyl-pyridine, 4-{5-[1-(4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-1,3,4]oxadiazol-2-yl}-2-methyl-pyridine, 4-{5-[1-(4-Cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,3,4]oxadiazol-2-yl}-2-methyl-pyridine, 4-{5-[1-(5-Furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,3,4]oxadiazol-2-yl}-2-methyl-pyridine, 2-(3-Chloro-phenyl)-5-{1-[4-methyl-5-(2-methyl-thiazol-4-yl)-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,3,4]oxadiazole, 3-(5-{1-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-2-methyl-pyridine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 5-(3-Chloro-phenyl)-3-{1-[5-(4-methoxy-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,2,4]oxadiazole, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 5-(5-Chloro-2-fluoro-phenyl)-3-{1-[5-(4-methoxy-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,2,4]oxadiazole, 4-[5-(4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-2-methyl-pyridine, 4-[5-(4-Cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-2-methyl-pyridine, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-[5-(5-Furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]-2-methyl-pyridine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-4-cyclopropylmethyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(4-Fluoro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,3,4]oxadiazol-2-yl)-2-methyl-pyridine, 4-(5-{1-[5-(3-Fluoro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-ylsulfanyl]-ethyl}-[1,3,4]oxadiazol-2-yl)-2-methyl-pyridine, 3-[3-(4-Cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-4-fluoro-benzonitrile, 4-Chloro-2-[3-(4-cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-phenol, 4-{4-Cyclopropyl-5-[5-(3-methoxy-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{4-Cyclopropyl-5-[5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{4-Cyclopropyl-5-[5-(3-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 4-[4-Cyclopropyl-5-(5-m-tolyl-[1,2,4]oxadiazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 3-[3-(4-Cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzonitrile, 4-{4-Cyclopropyl-5-[5-(2,5-difluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{4-Cyclopropyl-5-[1-(5-m-tolyl-[1,2,4]oxadiazol-3-yl)-ethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 4-(4-Cyclopropyl-5-{1-[5-(3-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 4-{5-[5-(2-Chloro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 2-[3-(4-Cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-4-methyl-phenol, 4-(5-{1-[5-(2-Chloro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, {3-[3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-phenyl}-methanol, 3-[5-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-3-yl]-phenol, 5-(3-Chloro-phenyl)-3-[4-(tetrahydro-faran-2-ylmethyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, (2-Chloro-phenyl)-{5-[5-(3-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-isobutyl-4H-[1,2,4]triazol-3-yl}-methanol, 5-(2-Fluoro-5-methyl-phenyl)-3-[5-thiophen-2-yl-4-(2,2,2-trifluoro-ethyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 3-(2,5-Difluoro-phenyl)-5-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-Furan-3-yl-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-(5-furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-(5-furan-3-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(5-furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(5-furan-3-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyrimidine, 4-{5-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyrimidine, 3-(5-Chloro-2-fluoro-phenyl)-5-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(5-Chloro-2-fluoro-phenyl)-5-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(5-Chloro-thiophen-2-yl)-3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(5-Chloro-thiophen-2-yl)-3-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(5-Chloro-thiophen-3-yl)-3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-ethyl-4H-1,2,4]triazol-3-ylmethoxy}-phenol, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-ylmethoxy}-phenol, 3-(2,5-Difluoro-phenyl)-5-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(2,5-Difluoro-phenyl)-5-(5-furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 4-(5-{1-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyrimidine, 2-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-5-methoxy-pyrimidine, 2-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyrimidine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-2-methoxy-pyridine, 5-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-2-methoxy-pyridine, 2-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-5-methoxy-pyridine, 3-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-6-methoxy-pyridazine, 3-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-{5-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 5-(3-Chloro-phenyl)-3-(5-furan-2-yl-4-isobutyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-(3-methylsulfanyl-propyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-hexyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-cyclopropylmethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-(3-fluoro-benzyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-(3-methyl-benzyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-(2-methyl-butyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-(3-methyl-butyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-[4-(2-fluoro-benzyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-yloxymethyl)[1,2,4]oxadiazole, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethoxy}-4-methyl-4H[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[3-(3-Chloro-phenyl)-isoxazol-5-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 5-(2-Methoxy-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-Furan-2-yl-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-[3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-benzoic acid methyl ester, 5-(2-Fluoro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(2,5-Difluoro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(3-vinyl-phenyl)-[1,2,4]oxadiazole, 5-(3-Difluoromethoxy-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(4-Methoxy-thiophen-3-yl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(2-Chloro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(4-Fluoro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-(3-Chloro-phenyl)-5-[1-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,2,4]oxadiazole, -(5-{1-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 3-(3-Chloro-phenyl)-5-[2-(4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(5-furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-ylmethyl)-[1,2,4]oxadiazole, 2-(3-Chloro-phenyl)-5-[2-(5-furan-2-yl-4-methyl-4H-[1,2,4]triazol-3-yl)-ethyl]-[1,3,4]oxadiazole, 2-(3-Chloro-phenyl)-5-[2-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-yl)-ethyl]-[1,3,4]oxadiazole, 2-(3-Chloro-phenyl)-5-[2-(4-cyclopropyl-5-furan-2-yl-4H-[1,2,4]triazol-3-yl)-ethyl]-[1,3,4]oxadiazole, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-ethyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-ethyl}-4-ethyl-4H[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-ethyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-propyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-propyl}-4cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-propyl}-4-cyclopropyl-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 8-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazol[4,3-a]pyridine, 8-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-3-thiophen-2-yl-5,6,7,8-tetrahydro-[1,2,4]triazol[4,3-a]pyridine, 8-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazol[4,3-a]pyridine, 5-(5-Bromo-4-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-3-(3-chloro-phenyl)-[1,2,4]oxadiazole, 3-[3-(4-Methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-phenylamine, 5-(3-Chloro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazole-3-sulfonylmethyl)-[1,2,4]oxadiazole, 5-(3-Chloro-phenyl)-3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazole-3-sulfinylmethyl)-[1,2,4]oxadiazole, 2-Methyl-6-[3-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridine, 4-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4ethyl-4H-[1,2,4]triazol-3-yl)-pyridin-2-ol, 4-(5-{2-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-propyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, [5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-methyl-(4-methyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-amine, 8-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazol[4,3-a]pyrimidine, 8-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazol[4,3-a]pyrimidine, 8-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazol[4,3-a]pyrimidine, 8-{1-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethyl}-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazol[4,3-a]pyrimidine, 8-[5-(5-Chloro-2-fluoro-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-3-furan-2-yl-5,6,7,8-tetrahydro-[1,2,4]triazol[4,3-a]pyrimidine, 8-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethyl}-3-pyridin-4yl-5,6,7,8-tetrahydro-[1,2,4]triazol[4,3-a]pyrimidine, 3-(4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-5-(1H-pyrrol-3-yl)-[1,2,4]oxadiazole, 4-{5-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine 1-oxide, 5-(3-Chloro-phenyl)-3-(2-furan-2-yl-3-methyl-3H-imidazol-4-ylsulfanylmethyl)-[1,2,4]oxadiazole, 5-(5-Chloro-2-fluoro-phenyl)-3-[4-(2-fluoro-ethyl)-5-thiophen-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-[1,2,4]oxadiazole, 5-(5-Chloro-thiophen-3-yl)-3-(4-ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazole, 3-[3-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-[1,2,4]oxadiazol-5yl]-4-hydroxy-benzonitrile, 3-(3-Chloro-phenyl)-5-[2-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]oxadiazole, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-propyl}-[1,3,4]oxadiaxol-2-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-1-methyl-ethyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-cyclopropyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, or 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,1-dimethyl-ethyl}-[1,3,4]oxadiazol-2-yl)-pyridine, 3-(5-{1-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethoxy}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(2-Chloro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(2,5-Difluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{1-[5-(2-Fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(4-Cyclopropyl-5-{1-[5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 3-{3-[1-(4-Methyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,2,4]oxadiazol-5-yl}-benzonitrile, 3-{3-[1-(4-Cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-[1,2,4]oxadiazol-5-yl}-benzonitrile, 3-{1-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-ethylsulfanyl}-5-pyridin-4-yl-[1,2,4]triazol-4-ylamine, 3-(3-Chloro-phenyl)-5-[2-(4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]oxadiazole, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-1-methyl-ethyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, cis-4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-cyclopropyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,1-dimethyl-ethyl}-1,3,4]oxadiazol-2-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-1-methyl-ethyl}-[1,3,4]-oxadiazol-2-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-cyclopropyl}-[1,3,4]oxadiazol-2yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-cyclopropyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-propyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-propyl}-[1,3,4]oxadiazol-2-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-propyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-(5-{2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-propyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, (S)-[1-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-2-(4-cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-ethyl]-carbamic acid tert-butyl ester, (S)-1-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-2-(4-cyclopropyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-ethylamine, (S)-[1-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-2-(4-cyclopropyl-5-pyridin-4yl-4H-[1,2,4]triazol-3-yl)-ethyl]-dimethyl-amine, or salt thereof.
18 . A pharmaceutical formulation comprising as active ingredient a therapeutically effective amount of a compound according to any one of claims 1 to 17 in association with one or more pharmaceutically acceptable diluent, excipients and/or inert carrier.
19 . The pharmaceutical formulation according to claim 18 , for use in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
20 . A compound according to any one of claims 1 to 17 for use in therapy.
21 . The compound according to claim 20 , for use in prevention and/or treatment of mGluR5 receptor-mediated disorders.
22 . The compound according to claim 20 , for use in prevention and/or treatment of neurological disorders.
23 . The compound according to claim 20 , for use in prevention and/or treatment of psychiatric disorders.
24 . The compound according to claim 20 , for use in prevention and/or treatment of chronic and acute pain disorders.
25 . The use of a compound according to any one of claims 1 to 17 in the manufacture of a medicament for the use in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
26 . A method of prevention and/or treatment of mGluR5 receptor-mediated disorders, comprising administering to a mammal, including man in need of such prevention and/or treatment, a therapeutically effective amount of a compound according to any one of claims 1 to 17 .
27 . A method for inhibiting activation of mGluR5 receptors, comprising treating a cell containing said receptor with an effective amount of a compound according to any one of claims 1 to 17 .
28 . Processes for the preparation of a compound according to claim 2 , comprising;
wherein R′ and R″ contains either a group represented in Formula I by M 2 -(R 3 ) n —X 4 -Q-(R 4 ) m2 or a leaving group such as (CH 2 ) n X, wherein X is any suitable leaving group such as chloro or mesylate or a group which may subsequently be transformed into a leaving group is and Q, X 4 , R 3 R 4 , M 2 , m and n are as defined in claim 1.Cited by (0)
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