Method for the isolation of sulfuric acid mono-[3({1-[2-(4-fluorophenyly)-ethyl]-piperidin-4-yl}-2-methoxy-phenyl}ester

Abstract

The present invention is directed to the method of isolation of sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT 2A antagonist (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.

What is claimed is:  
     
         1 . A method of isolating a compound of formula I or its enantiomers from an appropriate sample comprising the steps of:  
       
         
           
           
               
               
           
         
         a) collecting the sample from a patient wherein the patient has been administered a therapeutically sufficient amount of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol;  
         b) optionally preparing the sample for isolation of the compound of Formula I or its enantiomers; and  
         c) isolating the compound of Formula I or at least one enantiomer from the sample.  
       
     
     
         2 . A method according to  claim 1  wherein the sample is plasma.  
     
     
         3 . A method according to  claim 1  wherein the sample is urine.  
     
     
         4 . A method according to  claim 1  wherein isolating is by chromatography.