Apparatus for measuring blood glucose concentrations

Abstract

An apparatus for measuring ocular and/or blood glucose levels comprises (a) an irradiating means ( 10 ) for irradiating light onto the eye ( 1 ) of a user from outside the cornea of the eye to excite an ocular glucose sensor in contact with an ocular fluid, said sensor being able to emit a total fluorescence having first and a second wavelength bands; (b) an optical path splitting means ( 11 ) for splitting said total fluorescence into a first fluorescence and a second fluorescence, said first fluorescence and said second fluorescence travelling along first and second optical paths; (c) a first detecting means ( 14 ) located in the first optical path; (d) a second detecting means ( 17 ) located in the second optical path; (e) a calculating means for calculating the intensity ratio or the first fluorecence to the second fluorescence and for determining an ocular glucose concentration in the ocular fluid; and (f) an arithmetic means for converting the ocular glucose concentration into a blood glucose concentration.

1 . An apparatus for measuring ocular and/or blood glucose levels, comprising: 
 (a) an irradiating means ( 10 ) for irradiating light onto the eye ( 1 ) of a user from outside the comea of the eye to excite an ocular glucose sensor, wherein said ocular glucose sensor is in contact with an ocular fluid and can emit a total fluorescence having a first and a second wavelength bands upon irradiation with said irradiating means ( 10 );    (b) an optical path splitting means ( 11 ) for spritting said total fluorescence having both bands into a first fluorescence having said first wavelength band and second fluorescence having said second wavelength band, wherein said first fluorescence travels along a first optical path and said second fluorescence travels along a second optical path;    (c) a first detecting means ( 14 ) located in the first optical path for detecting the intensity of the first fluorescence at a first wavelength;    (d) a second detecting means ( 17 ) located in the second optical path for detecting the intensity of the second fluorescence at a second wavelength;    (e) a calculating means for calculating the intensity ratio of the first fluorescence to the second fluorescence and for determining based on the calculated intensity ratio an ocular glucose concentration in the ocular fluid of the user according to a predetermined calibration table or calibration curve; and    (f) an arithmetic means for converting the ocular glucose concentration determined by the calculating means into a blood glucose concentration by referring to a predetermined correlation between blood glucose concentrations and ocular glucose concentrations.    
     
     
         2 . An apparatus according to  claim 1 , further comprising a displaying means for visually displaying the blood glucose concentration determined by the arithmetic means.  
     
     
         3 . Anapparatus according to  claim 1  or  claim 2 , further comprising a transmitting means for transmitting a signal to a pump, wherein said signal contains instructions for the pump to inject an amount of insulin into a tissue of the user.  
     
     
         4 . An apparatus according to any one of the preceding claims, wherein said irradiating means ( 10 ) emits a light of third and fourth wavelengths which are different.  
     
     
         5 . A kit for calibrating an apparatus according to any one of the preceding claims, comprising an apparatus according to any one of  claims 1  to  4  and at least three solutions of known glucose concentrations which are different.  
     
     
         6 . A kit according to  claim 5 , wherein said known glucose concentrations are evenly distributed over a concentration range from 0 to 500 mg/L.  
     
     
         7 . A kit of  claim 5  or  claim 6 , further comprising an instruction for calibrating the apparatus for measuring ocular glucose concentrations.