US2004170611A1PendingUtilityA1

Methods of modulating hair growth

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Assignee: GEN HOSPITAL CORPPriority: Mar 31, 2000Filed: Mar 2, 2004Published: Sep 2, 2004
Est. expiryMar 31, 2020(expired)· nominal 20-yr term from priority
Inventors:Bruce A. MorganJiro KishimotoRobert Burgeson
A61P 39/00A61P 43/00A61P 17/14G01N 33/6872C12N 2501/415C12N 2500/12G01N 2333/475C12N 5/0627A61Q 7/00A61K 38/18G01N 2500/00A61K 48/00A61K 33/14
57
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Claims

Abstract

The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.

Claims

exact text as granted — not AI-modified
What is claimed:  
     
         1 . A method of promoting hair growth in a subject, comprising: 
 providing a dermal papilla (DP) cell;    culturing the DP cell in the presence of a Wnt polypeptide or a functional fragment or analog thereof, and    grafting the cultured DP cell onto the skin of a subject, thereby promoting hair growth in the subject.    
     
     
         2 . The method of  claim 1 , wherein the subject is a human.  
     
     
         3 . The method of  claim 1 , wherein the DP cell is autologous.  
     
     
         4 . The method of  claim 1 , wherein the DP cell is allogeneic  
     
     
         5 . The method of  claim 1 , wherein the Wnt polypeptide is Wnt 3a.  
     
     
         6 . The method of  claim 1 , wherein the Wnt polypeptide Wnt 3.  
     
     
         7 . The method of  claim 1 , wherein the Wnt polypeptide is Wnt 4.  
     
     
         8 . The method of  claim 1 , wherein the Wnt polypeptide is Wnt 7a.  
     
     
         9 . The method of  claim 1 , wherein the Wnt polypeptide is Wnt 7b.  
     
     
         10 . The method of  claim 1 , wherein the Wnt polypeptide is recombinant.  
     
     
         11 . The method of  claim 1 , wherein the Wnt polypeptide has been exogenously added to the cell culture.  
     
     
         12 . The method of  claim 1 , wherein the DP cell is cultured in the presence of a cell that expresses the Wnt polypeptide.  
     
     
         13 . The method of  claim 1 , wherein the cell is cultured in the presence of a Wnt polypeptide.  
     
     
         14 . The method of  claim 13 , wherein the subject is a human.  
     
     
         15 . The method of  claim 13 , wherein the DP cell is autologous.  
     
     
         16 . The method of  claim 13 , wherein the DP cell is allogeneic  
     
     
         17 . The method of  claim 13 , wherein the Wnt polypeptide is Wnt 3a.  
     
     
         18 . The method of  claim 13 , wherein the Wnt polypeptide Wnt 3.  
     
     
         19 . The method of  claim 13 , wherein the Wnt polypeptide is Wnt 4.  
     
     
         20 . The method of  claim 13 , wherein the Wnt polypeptide is Wnt 7a.  
     
     
         21 . The method of  claim 13 , wherein the Wnt polypeptide is Wnt 7b.  
     
     
         22 . The method of  claim 13 , wherein the Wnt polypeptide is recombinant.  
     
     
         23 . The method of  claim 13 , wherein the Wnt polypeptide has been exogenously added to the cell culture.  
     
     
         24 . The method of  claim 13 , wherein the DP cell is cultured in the presence of a cell that expresses the Wnt polypeptide.

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