US2004170698A1PendingUtilityA1

Bowel cleansing composition

55
Priority: Jul 15, 2002Filed: Jan 14, 2004Published: Sep 2, 2004
Est. expiryJul 15, 2022(expired)· nominal 20-yr term from priority
Inventors:George Halow
A61K 45/06A61K 31/765A61K 33/42
55
PatentIndex Score
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Cited by
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References
0
Claims

Abstract

The invention provides compositions for rapid bowel cleansing comprising a water-soluble mixture of polyethylene glycol and sodium phosphate(s). The compositions are particularly useful for preparing the bowel prior to surgery or diagnostic procedures such as colonoscopies. The invention further comprises methods for cleansing the bowel using these compositions, and bowel cleansing kits comprising these compositions.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A water-soluble dry bowel cleansing composition comprising from 10 to 50% by weight of an uncoated phosphate powder comprising dibasic sodium phosphate or an admixture of dibasic sodium phosphate and monobasic sodium phosphate and from 50 to 90% by weight water-soluble or water-miscible polyethylene glycol (PEG), based on the combined weight of PEG and phosphate.  
     
     
         2 . The composition of  claim 1 , wherein the sodium phosphate powder is dibasic sodium phosphate.  
     
     
         3 . The composition of  claim 1 , wherein the sodium phosphate powder is a mixture of dibasic sodium phosphate and monobasic sodium phosphate.  
     
     
         4 . The composition of  claim 1 , wherein the composition contains from 20 to 40% by weight sodium phosphate powder and from 60 to 80% by weight PEG, based on the combined weight of PEG and phosphate.  
     
     
         5 . The composition of  claim 2 , wherein the composition contains from 20 to 40% by weight sodium phosphate powder and from 60 to 80% by weight PEG, based on the combined weight of PEG and phosphate.  
     
     
         6 . The composition of  claim 3 , wherein the composition contains from 20 to 40% by weight sodium phosphate powder and from 60 to 80% by weight PEG, based on the combined weight of PEG and phosphate.  
     
     
         7 . The composition of  claim 1 , wherein the composition contains from 20 to 30% by weight sodium phosphate powder and from 70 to 80% by weight PEG, based on the combined weight of PEG and phosphate.  
     
     
         8 . The composition of  claim 2 , wherein the composition contains from 20 to 30% by weight sodium phosphate powder and from 70 to 80% by weight PEG, based on the combined weight of PEG and phosphate.  
     
     
         9 . The composition of  claim 3 , wherein the composition contains from 20 to 30% by weight sodium phosphate powder and from 70 to 80% by weight PEG, based on the combined weight of PEG and phosphate.  
     
     
         10 . The composition of  claim 1 , further comprising a bowel stimulant.  
     
     
         11 . The composition of  claim 10 , wherein the bowel stimulant is bisacodyl.  
     
     
         12 . The composition of  claim 10 , wherein the bowel stimulant is Cascara sagrada.  
     
     
         13 . A single dosage of a water-soluble dry bowel cleansing composition comprising from 5 grams to 45 grams of an uncoated phosphate powder comprising dibasic sodium phosphate or an admixture of dibasic sodium phosphate and monobasic sodium phosphate, and from 45 grams to 130 grams water-soluble or water-miscible PEG.  
     
     
         14 . A single dosage of the composition of  claim 13 , comprising from 10 grams to 30 grams of phosphate powder and from 45 grams to 70 grams PEG.  
     
     
         15 . A single dosage of the composition of  claim 14 , comprising from 15 grams to 25 grams of phosphate powder and from 55 grams to 65 grams PEG.  
     
     
         16 . A method for cleansing the bowel comprising orally administering at least one dosage according to  claim 13 , dissolved in an aqueous medium.  
     
     
         17 . A method for cleansing the bowel comprising orally administering at least one dosage according to  claim 14 , dissolved in an aqueous medium.  
     
     
         18 . A method for cleansing the bowel comprising orally administering at least one dosage according to  claim 15 , dissolved in an aqueous medium.  
     
     
         19 . A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage according to  claim 13 , dissolved in an aqueous medium, within the 36 hour period preceding the procedure.  
     
     
         20 . A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage according to  claim 14 , dissolved in an aqueous medium, within the 36 hour period preceding the procedure.  
     
     
         21 . A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage according to  claim 15 , dissolved in an aqueous medium, within the 36 hour period preceding the procedure.  
     
     
         22 . A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage of a composition according to  claim 13 , dissolved in an aqueous medium, within the 36 hour period preceding the procedure and while maintaining a clear liquid diet.  
     
     
         23 . A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage of a composition according to  claim 14 , dissolved in an aqueous medium, within the 36 hour period preceding the procedure and while maintaining a clear liquid diet.  
     
     
         24 . A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering at least one dosage of a composition according to  claim 15 , dissolved in an aqueous medium, within the 36 hour period preceding the procedure and while maintaining a clear liquid diet.  
     
     
         25 . A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering on the day before the procedure at least two dosages of a composition according to  claim 13 , each dissolved in or taken with at least one quart of an aqueous medium.  
     
     
         26 . A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering on the day before the procedure at least two dosages of a composition according to  claim 14 , each dissolved in or taken with at least one quart of an aqueous medium.  
     
     
         27 . A method for cleansing the bowel prior to a medical or surgical procedure comprising orally administering on the day before the procedure at least two dosages of a composition according to  claim 15 , each dissolved in or taken with at least one quart of an aqueous medium.  
     
     
         28 . A single dosage of a dry bowel cleansing composition according to  claim 1 , comprising from 5 grams to 45 grams of a water-soluble phosphate powder comprising dibasic sodium phosphate or an admixture of dibasic sodium phosphate and monobasic sodium phosphate, and from 45 grams to 130 grams water-soluble PEG.  
     
     
         29 . A single dosage of the composition of  claim 28 , comprising from 10 grams to 30 grams of phosphate powder and from 45 grams to 70 grams PEG.  
     
     
         30 . A single dosage of the composition of  claim 29 , comprising from 15 grams to 25 grams of phosphate powder and from 55 grams to 65 grams PEG.  
     
     
         31 . A bowel cleansing kit comprising one or more dosages of a dry composition according to  claim 13 , one or more clear liquid diet powders, and optionally a flavor pack or other adjuvant.  
     
     
         32 . A bowel cleansing kit comprising one or more dosages of a dry composition according to  claim 14 , one or more clear liquid diet powders, and optionally a flavor pack or other adjuvant.  
     
     
         33 . A bowel cleansing kit comprising one or more dosages of a dry composition according to  claim 15 , one or more clear liquid diet powders, and optionally a flavor pack or other adjuvant.  
     
     
         34 . A bowel cleansing kit comprising one or more dosages of a dry composition according to  claim 28 , one or more clear liquid diet powders, and optionally a flavor pack or other adjuvant.  
     
     
         35 . A bowel cleansing kit comprising one or more dosages of a dry composition according to  claim 29 , one or more clear liquid diet powders, and optionally a flavor pack or other adjuvant.  
     
     
         36 . A bowel cleansing kit comprising one or more dosages of a dry composition according to  claim 30 , one or more clear liquid diet powders, and optionally a flavor pack or other adjuvant.  
     
     
         37 . A liquid bowel cleansing composition comprising from 10 to 50% by weight of dibasic sodium phosphate or an admixture of dibasic sodium phosphate and monobasic sodium phosphate and from 50 to 90% by weight polyethylene glycol (PEG) which is a liquid at room temperature, based on the combined weight of PEG and phosphate.  
     
     
         38 . The composition of  claim 37 , wherein the sodium phosphate is dibasic sodium phosphate.  
     
     
         39 . The composition of  claim 38 , wherein the sodium phosphate is a mixture of dibasic sodium phosphate and monobasic sodium phosphate.  
     
     
         40 . The composition of  claim 37 , wherein the sodium phosphate is a powder.  
     
     
         41 . The composition of  claim 37 , wherein the sodium phosphate is in an aqueous solution.

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